I’m really pleased to share that our paper is out in Developmental Cell! NGN3 oscillates in the developing pancreas and controls the timing of cell differentiation via an incoherent feed-forward motif. For more details check out the comments below and DOI: 10.1016/j.devcel.2025.06.004

03.07.2025 13:10 — 👍 16    🔁 5    💬 3    📌 1

Great work from Mochulska & Francois developing a generative framework for systematically building Dynamical Landscapes of cell fate decision making using modular dynamical components

Important step to interpretable and predictive models of cellular differentiation

www.biorxiv.org/content/10.1...

16.06.2025 05:49 — 👍 22    🔁 6    💬 0    📌 1

Join us for the next @physicsoflifeuk.bsky.social PDRA-led Seminar:

Tues 10 June | 🕑 2–3 PM BST | 💻 Zoom
With talks from Petr Sherin & Darryl Overby (Imperial), chaired by @jcammann.bsky.social

Register now for the Zoom link:
forms.gle/epdhsHSW2JVv...

05.06.2025 13:11 — 👍 1    🔁 1    💬 0    📌 0

Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data Building a mechanistic understanding of cell fate decisions remains a fundamental goal of developmental biology, with implications for stem cell therapies, regenerative medicine and understanding dise...

Our latest "Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data"

A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making

Applied to ventral neural tube development

www.biorxiv.org/content/10.1...

29.05.2025 12:08 — 👍 135    🔁 52    💬 5    📌 3

Excited to share that my latest preprint! We use dual reporters and computation to explore the bistable HES1-HES5 motif and find that oscillations enable a hybrid state characterised by synchrony of HES1 and HES5 resolving into single HES during the development of mouse embryonic spinal cord.

29.05.2025 16:10 — 👍 7    🔁 3    💬 0    📌 0

Congratulations to @anzymiller.bsky.social and the fellow PIs for being selected on a great career development opportunity!

07.05.2025 09:36 — 👍 3    🔁 0    💬 0    📌 0

PI programme | Development | The Company of Biologists PI programme | Development | The Company of Biologists Development's Pathway to Independence programme Development is excited to announce our call for our Pathway to Independence program...

We're very excited to announce that our colleague @anzymiller.bsky.social is about to begin her @dev-journal.bsky.social Pathway to Independence journey! This will provide mentoring and support to emerging researchers in developmental biology and stem cells . journals.biologists.com/dev/pages/pi...

07.05.2025 09:33 — 👍 3    🔁 1    💬 0    📌 1

Join us online today!

15.04.2025 09:29 — 👍 0    🔁 0    💬 0    📌 0

Join us online next Tuesday 15th April from 2-3pm UK time for another exciting Physics of Life ECR talk session!

10.04.2025 12:35 — 👍 2    🔁 0    💬 0    📌 0

The Company of Biologists 100 logo to the left and QR code to the right. Portrait of John Gurdon to the left, text to the right 100 extraordinary biologists John Gurdon John Gurdon was Chair of the Board of Directors from 2001 to 2011. He published many articles in Development, including some of the work that led to his 2012 Nobel Prize for cloning amphibians by nuclear transfer. #100biologists #biologists100

We are also highlighting John Gurdon, 2012 Nobel laureate in Physiology or Medicine and former Chair of the Board of Directors at @biologists.bsky.social, as an extraordinary biologist. #100biologists

10.04.2025 12:13 — 👍 24    🔁 8    💬 1    📌 0