Pietro Pichierri

The data is from April but holy moly

Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...

It should be noted that Google has noticed the backlash enough that they quietly published a code that would removed AI results for their searches.

An enterprising person built a default site to search without AI, and the results are goddamn refreshing as hell.
udm14.org

RAD51 and Cancer. A must read by Bernard Lopez in Oncogene.

Excited to have contributed to this new @cp-molcell.bsky.social paper on how PARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed.

A big congrats to Jonas for driving this work forward, great to see the results out!

👉 10.1016/j.molcel.2025.09.006

Limited overlap between genetic effects on disease susceptibility and disease survival - Nature Genetics Systematic comparison of genome-wide association results for disease risk and disease-specific mortality for nine common diseases across seven biobanks finds limited overlap between genetic effects on disease susceptibility and survival.

www.nature.com/articles/s41...

Republicans would rather shut down the government than help millions of Americans afford health care. This article tells some of their stories, and is a good reminder of what’s at stake.

ICYMI: Can we drive anti-tumor immunity in advanced prostate and ovarian cancers?

Arul M. Chinnaiyan & team find pharmacologic degradation of CDK12/13 delays tumor growth and improves ICB response in several cancer models: buff.ly/dtduyFp

Join us at the Hubrecht Institute in Utrecht to start your research group! Fantastic scientific environment, strong support, and nice colleagues :) Apply and please share broadly in your network.

In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma - Nature In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.

Nature research paper: In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma

go.nature.com/3IeODUh

NIH pulled off a ‘near miracle.’ Scientists say there’s still a problem. The National Institutes of Health is on track to give away all of its grant money to labs, but research on cancer, aging and diabetes is still being left behind.

Important well-explained summary: “NIH has awarded nearly 3,000 fewer research project grants than it did the previous year”.

Korsten et al. employ live cell imaging and expansion microscopy to show that nuclear polyQ aggregates associated with #HuntingtonDisease induce nuclear envelope (NE) blebbing and cause NE ruptures. rupress.org/jcb/article/...

📕 In our Intermediate Filaments collection: rupress.org/jcb/collecti...

Germany's Helsing unveils 'Europa' combat drone German defence startup Helsing unveiled a new autonomous combat drone, joining a race to build remote-piloted systems that can swarm into battle with fellow robots or team up with crewed fighters to help reshape the future of air warfare.

...we fund more to kill than to live

When a society pours more time and money into more creative ways to kill fellow humans than into better lives or a livable planet, we’re off course.

www.reuters.com/business/aer...

"Of the 557 drug approvals in our sample, 331 (59.4%) have a patent that cites a research publication acknowledging NIH support. Indeed, more than half of approved drugs (286, or 51.4%) are linked to at-risk research—research funded by grants that would have been cut under a 40% budget reduction." 🧪

🧪 🌊

The latest work from ours and @vram142.bsky.social lab is out! True teamwork to visualize nascent chromatin with strand resolution, using a fully reconstituted system. Very proud of superstar-PhD student Bruna, and @palindromephd.bsky.social. Learning so much from Vijay’s amazing technologies! RT

depmap miner logo

The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data!
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.

Start mining data now: dataminer.depmap.sanger.ac.uk

20. Optimal levels of scientific risk will be very different for individuals in these different circumstances. Team formation is often viewed in terms of complementarity of skills and capital; our model suggests that aligned incentives will be another important dimension of team success.

/fin

awesome to see this out —
congrats to Simona Giunta and all the authors

My quote of the day

A new breed of Republicans has taken over the GOP. It is a new breed which is seeking to sell to Americans a doctrine which is as old as mankind - the doctrine of racial division, the doctrine of racial prejudice, the doctrine of white supremacy.

Jackie Robinson (1963)

Grazie Maurizio per questo thread

Thread. Oggi, 15 anni fa, arrivavo negli US. Atterravo al Logan airport di Boston, proveniente da Barcellona, con un biglietto di sola andata. Avevo due valigie, 5 notti pagate in un hotel e un lavoro al Mass General Hospital, affiliato alla Harvard Medical School.

I’ve spent a good chunk of my career relying on American science and engineering to keep me alive. Yesterday, RFK Jr. testified at the U.S. Senate Finance Committee. It was sad to see him try to destroy the life’s work of so many American scientists. He shouldn’t be in this job.

I supervise an excellent postdoc who's looking for a postdoc or associate position in < 1 yr. Highly skilled in chem biol and biochem (peptide synthesis, native chem ligation, bacterial expression, purification, intein-based splicing, crystallography, interaction assays). Contact me if interested.

The September issue of Cancer Discovery @aacrjournals.bsky.social
is now online! The cover features work by Yuxuan Wang, Nickolas Papadopoulos, Elizabeth Platz, Bert Vogelstein, et al. showing ctDNA is detectable ≥3 years before cancer diagnosis - read that & more: aacrjournals.org/cancerdiscov...

DNA2 enables growth by restricting recombination-restarted replication - Nature DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

Thoughtful thread about the good news about proposed NIH budget, but also the limitations of a reasonable budget in preventing the Administration's destructive shenanigans.

Yes, it was carefully hidden in the New England Journal of Medicine.

Pfizer/BioNTech vaccine (www.nejm.org/doi/pdf/10.1... )

1/2

DgeaHeatmap: An R Package for Transcriptomic Analysis and Heatmap Generation. #Transcriptomics #Heatmaps #Genomics #R
academic.oup.com/bioinformati...