Manvendra Singh

Thanks a lot 🙏, I can't wait to see you!

Many Congratulations @retrogenomics.bsky.social , very well deserved and well earned. 🙏🏽

I love these recipes 🤗

Such a great award and the reward too. Very well deserved @m-vincendeau.bsky.social , Many congratulations and hopefully many more to come ☺️
Keep cementing the #TEsky up above and high.

Incredible article and resource too. Congratulations @kaessmannlab.bsky.social

🙏 Thanks a lot Marianne. It was totally my pride and pleasure

Lucky you 🤗🤗

Gave a talk at @institutcurie.bsky.social on Friday and honestly… it felt unreal. Speaking in the same place where Marie Curie carried out her radiation experiments reminds how long science lasts beyond us.
Thnks Elena Zueva, @mburbage.bsky.social , Sebastian Amigorena, Josh Waterfall and Lorena 🙏🏽

Can’t wait Mariana. You’ll rock here

Congratulations and all the best

Psoriasis: Unraveling the Causes of Chronic Itching In psoriasis and other inflammatory skin diseases, chronic itching or pruritus is a particularly distressing symptom for patients which remains difficult to treat today. Scientists at the Institut Pas...

🧠🧬 Psoriasis: Unraveling the Causes of Chronic Itching

@belkaidlab.bsky.social and Institut Pasteur researchers show that an excessive immune response to skin microbes activates the IL‑17A pathway in nerves, leading to chronic itch and nerve regrowth.

👉 www.pasteur.fr/en/home/rese...

Thanks, it was so much fun 🙏

🦠 Closing our session is @manusingh.bsky.social discussing the "Long Shadow of Viral Infections".
He's showing how HIV & EBV can reactivate persistent, ancient Endogenous Retroviral proteins. A powerful reminder that our genome's history still dictates our health today!🧬

Phenomenal!!

Of course! I remember Jason’s valiant effort digging into mouse TEs. Super happy to see it out finally 🙏🏽🙏🏽

#TESKY 🎉 Phenomenal work! After the humans, the variety of mouse immune cell systems also co-opts transposon-derived enhancers/promoters. Big Kudos to Jason, Andrew Grimson, and @cedricfeschotte.bsky.social

#neuroscience #brainresearch #institutimagine #natureneuroscience #neurodevelopment #genetics | Institut Imagine Does a neuron’s "address" define its function? 🧠 We are thrilled to share a new study published in Nature Neuroscience—also featured in Le Figaro—that challenges long-standing assumptions about how t...

Does a neuron’s "address" define its function? 🧠
Featured in @lefigaro.fr, new nature neuroscience research from Denis Jabaudon & colleagues shows that misplaced neurons can work perfectly & process senses. Brain structure ≠ function!
For more information: www.linkedin.com/posts/instit...

Btw! #Umut has joined bluesky with ID @cakirumut.bsky.social

Finally, to cross-validate - Independent TF ChIP-seq shows neurogenic TFs (FOXG1, NEUROD1/2, NEUROG2, ASCL1) selectively bind TE-derived sequences, thus supporting a model where EPO engages a transposon-based regulatory reservoir to drive adult neurogenesis.🧵8/8

Here’s the twist we’re most excited about:
A sizeable fraction of EPO-responsive regulatory elements overlaps ancient transposable elements (LINEs/SINEs). These aren’t “genomic fossils” but they behave like reusable regulatory modules the brain can recruit during plasticity. 🧵7/8

The most striking effect sits in newly formed / immature pyramidal neurons.
EPO preferentially boosts accessibility and gene programs that look like a neurogenic push plus synaptic integration
🧵6/8

The strongest remodeling concentrates in excitatory neuronal lineages in dentate gyrus, with distinct responses across glia and neuroimmune compartments. This is why bulk approaches miss the story 🧵5/8

We see broad, lineage-resolved chromatin opening (differential accessibility) that aligns with transcriptional activation of programs linked to neuronal differentiation, synaptogenesis, and plasticity. And a major portion of accessibility changes occurred around Transposons near these genes. 🧵4/8

Our atlas resolves diverse lineages and their cell-type-specific regulatory “grammar” (motifs/TF programs) through specific regulatory codes. 🧵3/8

We built a matched snRNA-seq + snATAC-seq atlas after rhEPO vs placebo to see which regulatory switches flip. 🧠✨
🧵2/8

🔥🎉 🧠 SuperThrilled to share our paper (preprint) - Human erythropoietin (rhEPO) reshapes the adult hippocampal chromatin landscape, around transposons to promote neurogenesis. 🧵1/8

Massive kudos to #UmutCakir who drove multi-omics through dark roads of the genome.

www.biorxiv.org/content/10.1...

🙏🏽🙏🏽 thanks Sarah, looking forward to get to know more about our cluster of Pasteur, Necker and Imagine 🙏🏽

Happy new year and 3 more days to apply for Computational biology post doc position in my lab #Paris #transpoosns @inem-necker.bsky.social @institutimagine.bsky.social

I'd love to be on this list. How to join?, Happy holidays!!

Phenomenal