Wythe Lab at UVA School of Medicine

Excited for this KRAS symposium at the NIH organized by Dr. Sarah Sheppard at the NIH. Should be a great meeting of heme/onc and vascular malformation clinicians and researchers.

The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2 Weiss et al. structurally and functionally characterize the interplay between the human BAF chromatin remodeler and nucleosome-bound pioneer transcription factors, uncovering a highly dynamic remodeling process in which nucleosome-bound transcription factors bias the direction of BAF remodeling to regulate genome access.

Online Now: The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2 Online now:

Switching fields or wanting to become an expert in #zebrafish research?
The @mblscience.bsky.social 2026 Zebrafish Development & Genetics course offers a fantastic opportunity to learn from leaders in the field!

Application deadline: March 2

Please spread the word!

www.mbl.edu/education/ad...

A solid power zone effort for one hour, going 21 miles, >1000 kcal, and >700 watts.

Why work on a talk for a symposium tomorrow when I can PR on the hotel peloton bike?

Moderna says FDA refuses its application for new mRNA flu vaccine The U.S. Food and Drug Administration is refusing to consider Moderna’s application for a new flu vaccine made with mRNA technology.

It is absolutely outrageous that Moderna’s flu vaccine was met with a “refusal-to-file” even after their approved their protocol with FDA and carried out the trial as agreed. This vaccine works better in older adults than the current flu vaccines.

apnews.com/article/mode...

$1.65M per day in DC alone. That’s approximately two NIH R01 Grant *years* burned per day. Ninety *five year* R01s projects burned in the last seven months with no end in sight.

Instead of lasting scientific advance we get….what?
Civil rights violations and authoritarian replacement of democracy.

🚀 Calling Postdocs in the Job Market ! 🚀
Want to showcase your research as you transition From Postdoc to PI?
Excited to announce a special opportunity just for you during the GERMAN FISH MEETING in Heidelberg !
Apply now
👉https://www.germanfishmeeting.org

#Postdoc #Research #Science #fishmodel

I have encountered a little of this.

My brother historically has received more praise than I.

When I visit India it’s awkward for me.

The women talk in the kitchen about cooking while the men sit in the living room talking about global affairs.

There is no space to talk about me or science.

Advances in genetics, signaling, & modeling of venous malformations

Research History
Genetic & Molecular Drivers - TIE2-L914F PIK3CA-H1047R
Experimental Models - hiPSC, Vessel-on-a-chip & Knock-in🐭

Lovely & timely reading😁

@boscololab.bsky.social #FrontCVM 2026
www.frontiersin.org/journals/car...

The G.O.P. Senator Who Can’t Stop Thinking About the Boy ICE Detained Katie Britt is uniquely positioned to reason with the Trump administration — when she chooses to speak up.

Representative Joaquin Castro of Texas said in a post on social media that he had picked up Liam and his father, Adrian Conejo Arias, from the Dilley detention center on Saturday night and escorted them to Minnesota on Sunday morning. He shared photos of the two on social media, including one showing Liam at the airport clutching what appeared to be a Pikachu toy and wearing a Pikachu backpack. Mr. Castro was part of a delegation of Democratic lawmakers who visited Liam and his father at the detention center last week, where he said Liam’s father had reported that the child was “very depressed” and hadn’t been eating well since they were detained earlier this month.

This is a remarkable @nytimes.com split screen:

A huge 3,526 word + photos profile on Sen Britt who "can't stop thinking about the boy ICE detained"

But Rep Jaoquin Castro- who actually got Liam Ramos out of detention & back home- gets no interview, no pix, just 116 words inside a story. WOW.

I am SO incredibly excited to announce the launch of a global list of Inspiring Black Scientists. You can use this list to nominate and connect with researchers. Please share and join us in highlighting these outstanding scientists for #BlackHistoryMonth and beyond!

www.wiley.com/en-us/resear...

Please share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine.

faculty-einstein.icims.com/jobs/17847/a...

For context, the Dems voting the most for Trump nominees are:

1) Jeanne Shaheen (NH): 53
2) Maggie Hassan (NH): 46
3) John Fetterman (PA): 44
4) Tim Kaine (VA): 38
5) Mark Kelly (AZ): 34
6t) Jacky Rosen (NV): 32
6t) Mark Warner (VA): 32
8) Ruben Gallego (AZ): 31)
9) Amy Klobuchar (MN): 30

Gov Spanberger has directed Virginia’s state law enforcement agencies to end 287g agreements with ICE, saying the agreements "improperly cede accountability and discretion over VA law enforcement" to the feds.

Very pleased with our newest publication! In this study, we identify the Calcineurin-NFAT-DSCR1.4 signaling pathway as a druggable driver of capillary malformations caused by the GNAQ p.R183Q mutation, which is associated with port-wine stains and Sturge-Weber syndrome.

🔗 article: rdcu.be/e2gRC

Trump admin is "destroying medical research," Senate report finds In a Senate hearing Tuesday, NIH director dismissed concern about research chaos.

Trump admin is "destroying medical research," Senate report finds arstechnica.com/health/2026/...

The Centre for Research in Cellular Biology of Montpellier (CRBM) is recruiting Junior / Senior Group Leaders - FocalPlane The Centre for Research in Cellular Biology of Montpellier (CRBM) is recruiting Junior / Senior Group Leaders to shape its research in the coming decade

The Centre for Research in Cellular Biology of Montpellier @crbm-montpellier.bsky.social is recruiting Junior/Senior Group Leaders.
Check out the details on our cell biology jobs board: focalplane.biologists.com/cell-biology...

I've told this story on ContrabandCamp but it's worth sharing for BHM because it's one of the greatest stories ever.

A thread.

My outstanding postdoc is looking for a research job in Albany, NY. Please forward all leads and RT!

The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements CHD4 directly limits transcription factor binding to chromatin, which prevents activation of silent or cryptic enhancers but facilitates activity of active enhancers.

Final version of our paper now published.
elifesciences.org/articles/109...

Take homes:
CHD4/NuRD directly limits transcription factor residence times. At active enhancers this keeps them working efficiently. At inactive enhancers it prevents TFs from getting a foothold and causing activation. 1/n

Scientific Editor, Cell Cell has an opening for a full-time scientific editor. If you are a passionate, mission-driven team player who loves thinking broadly about science and wants to have a positive impact, we invite you t...

Cell is hiring!

Do you have a background in #neuroscience or #immunology? Better still, #neuroimmunology? Cell has an opening for a full-time scientific editor. Role will be based out of any one of our offices in Medford, MA, UK, Spain, Netherlands, China tinyurl.com/4ma236xn @cp-cell.bsky.social

Spatiotemporal coordination of Slit-Robo repulsion and neurturin-Gfrα attraction guides multipolar migration during retinal lamination Multipolar migration is a conserved neuronal migration mode in the developing brain, enabling emerging neurons to navigate in crowded environments and…

Check out the tour de force by @jalehtimaki.bsky.social in its final form: www.sciencedirect.com/science/arti... . An elegant combination of transcriptomics, F0 screens and high end imaging unravels the cues that guide cells (here retinal horizontal cells) in an increasingly crowded tissue. #proudPI

Spatial genomics of AAV vectors reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo - Nature Biotechnology Profiling transcriptional crosstalk between promoters and cell-type-specific enhancers allows large gene cargo delivery.

Profiling transcriptional crosstalk between promoters and cell-type-specific enhancers allows large gene cargo delivery go.nature.com/4kFUnEO
rdcu.be/e1bCR

A Common Iba1 Antibody Labels Vasopressin Neurons in Mice There are a wide variety of commercially available antibodies for labeling microglial cells based on different protein targets, as well as antibodies for the same protein target made in different spec...

PSA for all #microglia lovers: certain Iba1 antibodies (see our new paper below for details) label not only microglia, but also vasopressin neurons, at least in mice. Brain region and species matter. A friendly reminder to always validate your antibodies! 🔬

www.eneuro.org/content/13/2...

State Knew ICE Plans for Merrimack As Early As Jan. 12 Documents obtained by the New Hampshire ACLU show state officials have known for weeks that Immigration and Customs Enforcement plans to turn a Merrimack warehouse into a prison.

WOW: State leaders say NH Governor Kelly Ayotte lied about her knowledge of ICE's plan to build a giant human warehouse in the state.

Documents obtained by @aclu-nh.bsky.social show the state government has known for weeks about the Merrimack facility bc ICE is actively pursuing legal approval.

A Day for Gaza Today, The Nation is turning over its website exclusively to stories from Gaza and its people. This is why.

Despite the ongoing death and suffering in Gaza, it's fallen out of the news. So today, @thenation.com is devoting its full website to stories from Gaza, written by reporters who have been there. Very proud of the magazine today.

www.thenation.com/article/worl...

Many of my science colleagues are not speaking out-I suspect due to the fear Phil notes, that they'll targeted for loss of funding. I hope they read this account of what happened at a faculty meeting at Frankfurt University in 1933 as the Nazi's took control 🧪
www.facinghistory.org/resource-lib...

In vivo detection of immune responses via cytokine activity labeling Cytokine receptor dimerization, induced by the binding of cytokines, can be converted into a genetically traceable fluorescent signal and engineered into reporter mouse lines to visualize processes in...

Tools
'To address this knowledge gap, we developed “cytokine cellular locating platforms” (CyCLoPs), a reporter system that translates cytokine receptor engagement into a genetically traceable signal.'
#Immunology
www.cell.com/cell/abstrac...