Alberto Sanz

Excellent work, Payam! Congratulations to you and the entire team on this insightful paper!

FULLY FUNDED PhD - Identifying Critical Periods for Mitochondrial Function in Drosophila Development and Lifespan at University of Glasgow on FindAPhD.com PhD Project - FULLY FUNDED PhD - Identifying Critical Periods for Mitochondrial Function in Drosophila Development and Lifespan at University of Glasgow, listed on FindAPhD.com

Two weeks left to apply for a PhD position in my laboratory at #Glasgow.
The project focuses on #Ageing, #Mitochondria, and #Drosophila, with emphasis on Complex I (CI) function.
Fees are fully covered for applicants eligible for UK Home Student status.
www.findaphd.com/phds/project...

FULLY FUNDED PhD - Identifying Critical Periods for Mitochondrial Function in Drosophila Development and Lifespan at University of Glasgow on FindAPhD.com PhD Project - FULLY FUNDED PhD - Identifying Critical Periods for Mitochondrial Function in Drosophila Development and Lifespan at University of Glasgow, listed on FindAPhD.com

There is a PhD Studentship in my laboratory starting in March 2026. Please contact me if you are interested.
www.findaphd.com/phds/project...

YouTube video by The Sanz Science Experience ROS Signalling, not ROS Damage: A new Paradigm in Ageing

ROS Signalling, not ROS Damage: A new Paradigm in Ageing youtu.be/yt1kiuOyNtY?... via
@YouTube
#Aging #ROS #Drosophila #Mitochondria

Pluripotent stem cell-based drug discovery uncovers sildenafil as a treatment for mitochondrial disease Mitochondrial disease encompasses inherited disorders affecting mitochondrial function. A severe and untreatable form of mitochondrial disease is Leigh syndrome (LS) causing psychomotor regression and...

Exciting news! Our most important work is out as preprint!

We suggest sildenafil as a treatment for mitochondrial disease Leigh syndrome, from stem and organoid model to mice and off-label use.

Next step is the clinical trial starting early next year!

www.medrxiv.org/content/10.1...

YouTube video by Science Sanz Hub NAD+ Boosters: Slowing Aging or Selling Hype?

NAD+ Boosters: Slowing Aging or Selling Hype? youtu.be/0QxzAz9B--Y?... via
@YouTube
#aging #healthyaging #NAD+ #NADH #muscle #supplements #hype

YouTube video by Science Sanz Hub What's Aging? A Survey Among Professionals

What's Aging? A Survey Among Professionals youtu.be/iX_QUwrHkfY?... via @YouTube #aging #surve #disagreement

YouTube video by Science Sanz Hub NAD+ Boosters: Slowing Aging or Selling Hype?

NAD+ Boosters: Slowing Aging or Selling Hype? youtu.be/0QxzAz9B--Y?... via
@YouTube
#aging #healthyaging #NAD+ #NADH #muscle #supplements #hype

YouTube video by Science Sanz Hub Age Deceleration and Reversal in C elegans

Age Deceleration and Reversal in C elegans youtu.be/QSmpKDEjYNA?... #aging #worms #celegans #dauer

YouTube video by Science Sanz Hub How Does a Fly Die? And why should we care?

How does a Fly Die? And why should we care? #Drosophila #Aging #Biology

youtu.be/-akcyD68-eA?...

A concise and excellent summary of our recent
@emboreports.org manuscript, now published in
@natsmb.nature.com.
www.nature.com/articles/s41...

Developmental mitochondrial complex I activity determines lifespan | EMBO reports imageimageTemporal manipulation of CI function reveals development as critical window where reduction of CI produces short-lived and stress sensitive adults characterised by maladaptive transcriptomic...

New paper from my laboratory in EMBO Reports doi.org/10.1038/s443.... Our study challenges what we know about #mitochondria & #aging.

YouTube video by Science Sanz Hub Timing Mitochondrial Dysfunction: The Key to Regulating Aging

A podcast discussing our paper on the role of CI on aging and mitochondrial disease:

www.youtube.com/watch?v=Usu7...

Thanks to the paper's first author,
@rhodophila
, all our collaborators, and Wellcome and BBSRC, among others, for funding this study.

Finally, it's too early to know if this happens in humans. If it does, early treatment of mitochondrial disease is crucial. If not, we must learn how adult flies cope with minimal CI and apply that knowledge to #humans.

#Omics analysis reveals differences between short- and long-lived individuals. These can be explored to identify which features of CI depletion are pathogenic (found only in short-lived flies) and which are not (found in long-lived flies).

Our results identify development as the critical stage where CI must function optimally, while age-related CI reduction in activity may act as an anti-ageing adaptation.

If we massively reduce CI levels only in adult flies, they do not live shorter but instead live longer than controls. Notably, this depletion exceeds the levels observed in aged flies and is comparable to the reduction seen in individuals suffering from #mitochondrialdisease.

During development, a small disruption of mitochondrial #ComplexI (CI) in #Drosophila enormously shortens adult lifespan. This disruption falls within the natural variability in mitochondrial respiration observed among wild-type strains.

Developmental mitochondrial complex I activity determines lifespan | EMBO reports imageimageTemporal manipulation of CI function reveals development as critical window where reduction of CI produces short-lived and stress sensitive adults characterised by maladaptive transcriptomic...

New paper from my laboratory in EMBO Reports doi.org/10.1038/s443.... Our study challenges what we know about #mitochondria & #aging.