Daniel McManus, PhD

Congratulations to Fred Ramsdell, Mary Brunkow and Shimon Sakaguchi - the 2025 Winners of the Nobel Prize in Physiology or Medicine. #Treg_cells #Foxp3 #Immune_regulation

CD7 regulates the persistence of terminally exhausted CD8+ T cells during chronic infection @cp-cellreports.bsky.social
www.cell.com/cell-reports... @bcmhouston.bsky.social

CD7 regulates the persistence of terminally exhausted CD8+ T cells during chronic infection Hyslop et al. identify CD7 as a tissue-specific receptor essential for maintaining terminally exhausted CD8+ T cells during chronic infection. CD7 is highly expressed on a CD101+Tim3low liver-resident...

Great new work from Will Hudson’s lab at @bcmhouston.bsky.social on the role of CD7 during CD8 T cell exhaustion! tinyurl.com/3c5mdyzr

hudsonlaboratory.com

@cp-cellreports.bsky.social

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?

You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

We are looking to hire post-docs to work on T cell responses to M. tuberculosis infection using murine and NHP models. If you know T cells and wanna work on the top global infectious killer check us out. BSL3 experience not required. The NIH intramural program in Bethesda MD is an amazing place!

Splenic fibroblastic reticular cells orchestrate dendritic cell maturation and facilitate CD8+ T cell priming and protective memory Fibroblastic reticular cells of the spleen coordinate inflammation for optimal antiviral T cell responses and protective memory.

I’m pleased to share my latest work, published in Science Advances.
In this study, we investigated how fibroblastic reticular cells (FRCs) that populate the white pulp of the spleen regulate immune responses to viral infections.

#immunology #immunosky

www.science.org/doi/10.1126/...

Diverse priming outcomes under conditions of very rare precursor B cells B cells that give rise to neutralizing antibody responses can be extremely rare in the naive B cell repertoire. Madden et al. show that delivery strategy and adjuvant selection affect the recruitment ...

One of our obsessions in the Crotty lab is to better understand B-cell immunology in the context of vaccines. Rare B cells can have antibody specificities particularly important for protection against some diseases. In our most recent paper…
@cp-immunity.bsky.social
www.cell.com/immunity/ful...

YouTube video by Open Box Science [Maria Cardenas] Differentiation fate of a stem-like CD4 T cell controls immunity to cancer

Fantastic talk and beautiful story from Maria Cardenas and @haydnkissick.bsky.social lab!

Hosted by @openboxscience.bsky.social

youtu.be/rC69rAz6OeE

Very excited our work out in @jem.org “Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection”
@wehi-research.bsky.social led by talented (and determined) PhD student @benjbroom.bsky.social
Thread below.

This campaign needs you now Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)

chng.it/YPmBFkS8xJ

Excellent Info Graphic. Share everywhere!

Using PAXgene as an alternative tissue preservative for spatial transcriptomics with #Xenium @10xgenomics.bsky.social - An insane amount of work and a very methodical investigation

My wife and I were postbac IRTAs 25 years ago. Neither would have pursued a career in research if not for this program

We have PhD students in Yale Immunobiology now who also came from this NIH program including (one amazing student in my lab)

This is a valuable program and has been for decades.

I’m excited to share our lab’s new preprint! We find that some exhausted T cell clones maintain the capacity form functional memory cells:
www.biorxiv.org/content/10.1...

1/ 🧵

Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer.

Excited for our lab's FIRST paper #ScienceImmunology! 🎉

Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social

Huge thanks to reviewers & @claireolingy.bsky.social 🙌

#Tpex #onthescoreboard

www.science.org/doi/full/10....

ImmunOctoberfest reloaded
@natimmunol.bsky.social
@annisch.bsky.social
www.nature.com/articles/s41...

Building Cure at the Seattle Children's Research Institute

Super excited to announce that the Joag Lab will officially open at @UW, @SCRI in March 2025! We will study the interplay between memory T cells and stromal, humoral, and innate immunity in mucosal tissues. researcherprofiles.seattlechildrens.org/Vineet.Joag. Hiring a technician and a postdoc!

Special thanks to my PhD mentor Rafi, my co-first author, Rajesh Valanparambil, and all the rest of our co-authors.

Image above shows CD8 T cells asking a crystal ball to predict infection outcome. Credit: ChatGPT4

Also see our companion paper from Dietmar Zehn's lab: tinyurl.com/yck3mdup

Excited to share my PhD work from Rafi Ahmed’s lab, now published in @nature.com. We show how CD8 T cells overcome the inability to predict how long a viral infection will last by making adaptable precursor cells a priori—an elegant strategy for a non-prescient immune system! tinyurl.com/53nrpsa6

Thank you, Mohamed!

Two beautiful stories out this month in Nature (Jan8, 2025) about the enigmatic decision making of stem cell like CD8+ T cells from Rafi and Dietmar's labs.

Have a look!

www.nature.com/articles/s41...
www.nature.com/articles/s41...

Two studies published in @nature.com today showing that Tpex-like cells develop independent from acute or chronic infection

#Tpex

www.nature.com/articles/s41...