Jordan Zhou

6/6 From what I've seen, many institutions have also noticed this shift and are focusing resources on these technological developments for the sake of developing treatments and undertaking research that is heavily transnational in lieu of basic science.

5/6 So what will future Nobels look like? It seems to me that, eventually, the age of discovery will end and be replaced with an age of innovation in which much of the most impactful research will be focused on the development of new technologies rather than discovery of a new protein or cell type

4/6 In addition, we now integrate multiple systems within each research project (e.g. neuro-immune, cancer-metabolism, cancer-immunology, etc.) and are studying interactions between cell types and, again, context-dependent functions, which do not generally get awarded the Nobel.

3/6 With the current methodologies, much of the research is focused on determining how different cell states and context-dependent functions of cells impact health, but these types of discoveries, although important, do not usually lead to paradigm shifting advances in the field warranting the Nobel

2/6 Today, with the spread of omics technologies, we have essentially already established what cells exist and have an idea of their overall functions. We will no longer be able to look at a disease, or a classification of diseases, and pin the blame on a new cell type. Problems are more complex.

1/6 With recent excitement around the #NobelPrize announcements, I think it's worth thinking about what the prize will look like in the future, especially for physiology and medicine. What happens when there’s nothing left to discover in medicine? Have we already picked the low-hanging fruit?

Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’ Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.

Tregs have been one of the central pillars of the field of immunology. It was only a matter of time before these contributions won the #NobelPrize. Much deserved!

www.nature.com/articles/d41...

The fact that public funds are used to publish publicly funded research in journals owned by private publishers, who then sell access to that research at ridiculous prices to entities that buy it with more public funds, is kind of insane.

With boost to NIH budget, Senate panel rejects Trump’s plan to slash agency Republicans on spending committee push back against proposed reorganization and overhead cuts

"The bill approved today by the Senate Committee on Appropriations includes $47.2 billion for NIH’s base budget, or about 1% more than this year."

www.science.org/content/arti...

"The U.S. Department of Health and Human Services (HHS) today announced the beginning of a coordinated wind-down of its mRNA vaccine development activities...."

cc: Sen. Bill Cassidy

Genome Sciences is looking for a Director of Departmental Computing. This is a rare opportunity for someone interested in leading our excellent IT team, building and maintaining computational infrastructure, and working closely with our faculty and labs uwhires.admin.washington.edu/ENG/candidat...

Utility of transgenic hematopoietic stem cell to generate a self-renewing source of tumor-specific cellular immunotherapy in human participants @natcomms.nature.com
www.nature.com/articles/s41...

Transcriptome analysis of archived tumors by Visium, GeoMx DSP, and Chromium reveals patient heterogeneity - Nature Communications Currently, there is an urgent need to evaluate the strengths and limitations of various probe-based full transcriptome methods for formalin-fixed paraffin-embedded tumor tissues. Here, the authors ana...

🎉 New paper alert. We benchmarked Visium, GeoMx, and Chromium for FFPE tumor analysis. Thanks @estellayixingdong.bsky.social for pushing this forward, & MOSAIC collaborators!
📄 www.nature.com/articles/s41...
#SpatialTranscriptomics #CancerResearch cc: @owkin.bsky.social @10xgenomics.bsky.social

ILC3s sense gut microbiota through STING to initiate immune tolerance Immune tolerance to gut microbiota is necessary for health, yet the mechanisms initiating it remain elusive. We profiled MHC II+ cells at single-cell …

Congrats to Wenqing on another wonderful paper that came out today in #Immunity!

www.sciencedirect.com/science/arti...

The gut microbiome connects nutrition and human health Nature Reviews Gastroenterology & Hepatology - In this Review, Sanz and colleagues discuss how diet shapes the gut microbiome, the role of diet–microbiome interactions on the immune,...

Thrilled to share our latest review on how the gut microbiome connects diet to health, now published in Nature Reviews Gastro & Hepa! Honored to co-sign this piece with outstanding PIs @eranelinav.bsky.social @jfcryan.bsky.social Yolanda Sanz Mélanie Deschasaux Rebekka Lambrecht rdcu.be/epret

Microglial STING is a central safeguard against neurological decline with age Immune pathways and cell types that protect against neurodegenerative processes with aging remain poorly understood. Sulka et al. demonstrate that the innate immune adaptor, STING, provides essential ...

Congrats to my good friend Shruti Sharma!
STING, provides essential protection against blood-brain barrier breaches and neuromotor deficits during physiological aging
@cp-cellreports.bsky.social
cell.com/cell-reports...

Postdoc positions available studying how niche cells drive GI diseases!

robertsinstitute.weill.cornell.edu/faculty/goto...

'However, we now report that food-specific pTreg cells are exclusively induced by the recently identified RORγt APCs4–8 and not by cDCs. Instead, our data suggest that pTreg–cDC1 interactions in steady-state limit the expansion of food-specific CD8αβ T cells.'
www.nature.com/articles/s41...

50+% cut to the US National Science Foundation budget is staggering. These include cuts for research in Chemistry. Physics, Geology, Math, Engineering, Computer Science.

Scientific discoveries and training of our next generation of scientists and engineers are halved.

How is that helping the US?

Immunity to respiratory viruses Mucosal Immunology Podcast · Episode

Start your week off with the latest episode of the Mucosal Immunology Podcast @societymucosalimm.bsky.social featuring @priyadevarajan.bsky.social with @marionbrunck.bsky.social @ashu-mangalam.bsky.social and more: open.spotify.com/episode/3dJF...

Article in Press AND Open Access! "Cell therapy with human IL-10-producing ILC2s enhances islet function and inhibits allograft rejection" by Colpitts et al. doi.org/10.1016/j.aj... @sarahcolpitts.bsky.social @sarahcrome.bsky.social #celltherapy #islettransplantation

I’m a dentist from India. The fluoride debate in the U.S. horrifies me While debates in the U.S. rage about potential overexposure to fluoride, people worldwide still lack basic access to it.

I’m a dentist from India. The fluoride debate in the U.S. horrifies me
I’ve seen what happens when children grow up with unfluoridated water
buff.ly/25koX2u

Sequence diversity lost in early pregnancy - Nature Around 1 in 136 pregnancies is lost due to a pathogenic small sequence variant genotype in the fetus.

Our paper @hakonjon.bsky.social (missing other colleagues from Bluesky!), Sequence diversity lost in early pregnancy, was published in Nature (@nature.com) today

www.nature.com/articles/s41...

Targeting symbionts by apolipoprotein L proteins modulates gut immunity @nature.com
www.nature.com/articles/s41...

Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias Mutations in RNA splicing factors are prevalent across cancers and generate recurrently mis-spliced mRNA isoforms. Here, we identified a series of bon…

'CD8 T cells reactive to mis-splicing-derived neoantigens exist in the per. blood of patients w spliceosomal mutant leukemias. However, these T cells have defective NFκB proinflammatory pathways, which might explain why these cells are unable to mount effective antigen-reactive immune responses'

Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics - Nature Genetics Comparison of paired primary and recurrent glioblastomas at the single-cell transcriptomic level describes molecular and cellular trajectories associated with tumor recurrence, highlighting extensive ...

1/ Truly excited to share our new study that I had to privilege to co-lead during my PhD alongside great friends and collaborators @masashi-nomura.bsky.social, @kevin-johnson.bsky.social and Luciano Garofano, published at Nature Genetics @natureportfolio.nature.com!

www.nature.com/articles/s41...