Jordan Zhou

Genome Sciences is looking for a Director of Departmental Computing. This is a rare opportunity for someone interested in leading our excellent IT team, building and maintaining computational infrastructure, and working closely with our faculty and labs uwhires.admin.washington.edu/ENG/candidat...

Utility of transgenic hematopoietic stem cell to generate a self-renewing source of tumor-specific cellular immunotherapy in human participants @natcomms.nature.com
www.nature.com/articles/s41...

Transcriptome analysis of archived tumors by Visium, GeoMx DSP, and Chromium reveals patient heterogeneity - Nature Communications Currently, there is an urgent need to evaluate the strengths and limitations of various probe-based full transcriptome methods for formalin-fixed paraffin-embedded tumor tissues. Here, the authors ana...

🎉 New paper alert. We benchmarked Visium, GeoMx, and Chromium for FFPE tumor analysis. Thanks @estellayixingdong.bsky.social for pushing this forward, & MOSAIC collaborators!
📄 www.nature.com/articles/s41...
#SpatialTranscriptomics #CancerResearch cc: @owkin.bsky.social @10xgenomics.bsky.social

ILC3s sense gut microbiota through STING to initiate immune tolerance Immune tolerance to gut microbiota is necessary for health, yet the mechanisms initiating it remain elusive. We profiled MHC II+ cells at single-cell …

Congrats to Wenqing on another wonderful paper that came out today in #Immunity!

www.sciencedirect.com/science/arti...

The gut microbiome connects nutrition and human health Nature Reviews Gastroenterology & Hepatology - In this Review, Sanz and colleagues discuss how diet shapes the gut microbiome, the role of diet–microbiome interactions on the immune,...

Thrilled to share our latest review on how the gut microbiome connects diet to health, now published in Nature Reviews Gastro & Hepa! Honored to co-sign this piece with outstanding PIs @eranelinav.bsky.social @jfcryan.bsky.social Yolanda Sanz Mélanie Deschasaux Rebekka Lambrecht rdcu.be/epret

Microglial STING is a central safeguard against neurological decline with age Immune pathways and cell types that protect against neurodegenerative processes with aging remain poorly understood. Sulka et al. demonstrate that the innate immune adaptor, STING, provides essential ...

Congrats to my good friend Shruti Sharma!
STING, provides essential protection against blood-brain barrier breaches and neuromotor deficits during physiological aging
@cp-cellreports.bsky.social
cell.com/cell-reports...

Postdoc positions available studying how niche cells drive GI diseases!

robertsinstitute.weill.cornell.edu/faculty/goto...

'However, we now report that food-specific pTreg cells are exclusively induced by the recently identified RORγt APCs4–8 and not by cDCs. Instead, our data suggest that pTreg–cDC1 interactions in steady-state limit the expansion of food-specific CD8αβ T cells.'
www.nature.com/articles/s41...

50+% cut to the US National Science Foundation budget is staggering. These include cuts for research in Chemistry. Physics, Geology, Math, Engineering, Computer Science.

Scientific discoveries and training of our next generation of scientists and engineers are halved.

How is that helping the US?

Immunity to respiratory viruses Mucosal Immunology Podcast · Episode

Start your week off with the latest episode of the Mucosal Immunology Podcast @societymucosalimm.bsky.social featuring @priyadevarajan.bsky.social with @marionbrunck.bsky.social @ashu-mangalam.bsky.social and more: open.spotify.com/episode/3dJF...

Article in Press AND Open Access! "Cell therapy with human IL-10-producing ILC2s enhances islet function and inhibits allograft rejection" by Colpitts et al. doi.org/10.1016/j.aj... @sarahcolpitts.bsky.social @sarahcrome.bsky.social #celltherapy #islettransplantation

I’m a dentist from India. The fluoride debate in the U.S. horrifies me While debates in the U.S. rage about potential overexposure to fluoride, people worldwide still lack basic access to it.

I’m a dentist from India. The fluoride debate in the U.S. horrifies me
I’ve seen what happens when children grow up with unfluoridated water
buff.ly/25koX2u

Sequence diversity lost in early pregnancy - Nature Around 1 in 136 pregnancies is lost due to a pathogenic small sequence variant genotype in the fetus.

Our paper @hakonjon.bsky.social (missing other colleagues from Bluesky!), Sequence diversity lost in early pregnancy, was published in Nature (@nature.com) today

www.nature.com/articles/s41...

Targeting symbionts by apolipoprotein L proteins modulates gut immunity @nature.com
www.nature.com/articles/s41...

Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias Mutations in RNA splicing factors are prevalent across cancers and generate recurrently mis-spliced mRNA isoforms. Here, we identified a series of bon…

'CD8 T cells reactive to mis-splicing-derived neoantigens exist in the per. blood of patients w spliceosomal mutant leukemias. However, these T cells have defective NFκB proinflammatory pathways, which might explain why these cells are unable to mount effective antigen-reactive immune responses'

Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics - Nature Genetics Comparison of paired primary and recurrent glioblastomas at the single-cell transcriptomic level describes molecular and cellular trajectories associated with tumor recurrence, highlighting extensive ...

1/ Truly excited to share our new study that I had to privilege to co-lead during my PhD alongside great friends and collaborators @masashi-nomura.bsky.social, @kevin-johnson.bsky.social and Luciano Garofano, published at Nature Genetics @natureportfolio.nature.com!

www.nature.com/articles/s41...

Dear mucosal immunologists!

Registration for the European Mucosal Immunology Group (EMIG) meeting in Aachen, Germany is now open.

Register and see you this July in Aachen! 👇🏼

emig2025.de

@petterbrodin.bsky.social @wiag.bsky.social @mucosalimmunol.bsky.social @societymucosalimm.bsky.social

Young, Pottinger Op-Ed: Funding for R&D Isn’t a Gift to Academia. It's Vital to U.S. Security. - Senator Young The following column by Senator Todd Young (R-Ind.) and Matthew Pottinger, Former Deputy National Security Advisor of the United States, was published in The Washington Post on March 24, 2025. By Sena...

Important message. Also important to remember that federal funding for science isn’t “given” to university laboratories - it is awarded based on highly competitive process, profs spend months/years on proposals that are reviewed by experts, most are rejected.

www.young.senate.gov/newsroom/pre...

Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated ...

Amped to share this masterclass of a paper spearheaded by @waisenberg.bsky.social, out today in Immunity. Will et al. provide a deeply detailed look into microglia dysfunction in Krabbe disease & show that microglia replacement therapeutically improves disease outcomes!

www.cell.com/immunity/ful...

Vaccination in pregnancy to protect the newborn - Nature Reviews Immunology In this Review, Male and Jones provide an overview of the current vaccines that are offered during pregnancy and to newborns, explaining the rationale behind the different vaccination programmes and t...

👶🏼 Many #vaccines are not effective in newborns. So how do we protect them from infectious disease?

🤰🏽 By vaccination in #pregnancy!

Here we review…

💉 Established campaigns vs whooping cough, flu, COVID

💡 New approaches to RSV, GBS

🌈 Future challenges, opportunities

#ReproSky #ImmunoSky #IDSky

Prenatal amoxicillin exposure induces depressive-like behavior in offspring via gut microbiota and myristic acid-mediated modulation of the STING pathway Amoxicillin is a widely used antibiotic globally, and its pervasive environmental presence poses significant risks to human health and ecosystems. Not…

#pregnancy #microbiome #health

Prenatal amoxicillin antibiotic
significantly disrupts gut microbiota
in offspring,

leading to M1 microglial polarization
and depressive behavior.

Lachnospira (increased by UVB/sunlight)
reverses these neurotoxic effects.
.
www.sciencedirect.com/science/arti...

B cells modulate lung antiviral inflammatory responses via the neurotransmitter acetylcholine www.nature.com/articles/s41...

NIH freezes funds to Harvard and four other universities, but can’t tell them Move follows broader White House attack on Harvard funding and stop-work orders to contractors

NIH freezes funds to Harvard and four other universities, but can’t tell them | Science | AAAS www.science.org/content/arti...

NIH freezes all research grants to Columbia University Amid negotiations with Trump, the university could risk losing nearly $700 million

Researchers at Columbia will now have to receive prior approval from the NIH before spending their grant money. This will cause significant disruptions, but it seems like it's still just the beginning. Many more institutions will likely be targeted.

www.science.org/content/arti...

We are witnessing the destruction of science in America | Paul Darren Bieniasz If we stay on this administration’s course, future life-saving medicines may never be invented

I could literally quote every single sentence of this commentary, so I'm not going to - just read the whole thing.

And thanks, Dr. Bieniasz, for saying it as it is and showing true leadership. We need that from more scientists and scientific leaders.

www.theguardian.com/commentisfre...

I love paying TurboTax a few hundred bucks every year to figure out how much money I owe the government, which the government already knows, but won't tell me because TurboTax pays legislators to keep the government from telling me. 😻