Maximilian Frosch

Sensory neurons shape local macrophage identity via TGF-β signaling Specialized macrophages are known to persist within tissue niches, but the molecular mechanisms guiding their sustained functional adaptation remain unclear. Kolter and Döring et al. show that local interactions between sensory nerves and macrophages activate TGF-β, which imprints and maintains nerve-associated macrophages that contribute to regeneration after tissue injury.

15.10.2025 19:55 — 👍 7    🔁 4    💬 0    📌 0

Ein Jahr vor der Entscheidung: So will die Uni Freiburg wieder Exzellenz-Universität werden Ein Jahr vor der Entscheidung: So will die Uni Freiburg wieder Exzellenz-Universität werden | Die Uni Freiburg war eine der ersten deutschen Exzellenz-Universitäten seit 2007, verbunden mit hohem inte...

🎬 Great feature from Baden TV Süd on @uni-freiburg.de's efforts & successes in its #ExcellenceStrategy!

🌍 The #ExcellenceClusters #CIBSS and #FutureForests play a vital role in driving interdisciplinary research and innovative applications for real-world impact.

➡️ Watch here: kurzlinks.de/w7wj

14.10.2025 10:14 — 👍 13    🔁 8    💬 1    📌 0

Great recap of the story and the breakthroughs behind the 2025 #NobelPrize in Physiology or Medicine! 🏅🏅🏅

06.10.2025 13:25 — 👍 5    🔁 2    💬 0    📌 0

The immunology of brain tumors The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.

The immunology of brain tumors | Science Immunology www.science.org/doi/10.1126/...

Happy to share this review article by @lukasbunse.bsky.social, Theresa Bunse and I @platten-lab.bsky.social, Michael Kilian, Fran Quintana @quintanalabhms.bsky.social.

04.10.2025 10:49 — 👍 24    🔁 11    💬 0    📌 0

🙏🏻

28.09.2025 17:00 — 👍 2    🔁 1    💬 0    📌 0

In a first, a gene therapy seems to slow Huntington disease Small study suggests uniQure drug could be first successful treatment for devastating brain disorder

“This is an immensely exciting development for the Huntington’s field.” https://scim.ag/4nnW62z

24.09.2025 22:10 — 👍 93    🔁 24    💬 1    📌 2

Interferons in health and disease The cytokine messenger proteins known as interferons are central to protective immune responses against infections, but they are also involved in inflammatory and autoimmune diseases. This review maps...

And a Review on interferons in health and disease www.cell.com/cell/fulltex...

21.08.2025 15:40 — 👍 9    🔁 6    💬 0    📌 0

Die Gewächshäuser des Botanischen Gartnes der Universität Freiburg spiegeln sich in der Glasfassade des Hilde-Mangold-Hauses. Foto: Klaus Polkowski

Die #UniversitätFreiburg hat im renommierten #ShanghaiRanking den 5. Platz von 51 deutschen Institutionen erreicht und gehört weiterhin zu den Top 101–150 Universitäten weltweit. ➡️ Mehr dazu: ufr.link/shanghai-2025 #Ranking

15.08.2025 09:17 — 👍 12    🔁 5    💬 0    📌 0

Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1 - Nature Microglia-derived IGF1 promotes the proliferation of GABAergic progenitors and neuroblasts in the human medial ganglionic eminence, contributing to the extended production of GABAergic neurons and an expanded cognitive capacity in the human brain.

Nature research paper: Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1

go.nature.com/4oF4v2G

12.08.2025 10:36 — 👍 12    🔁 2    💬 0    📌 0

Microglia–neuron crosstalk via Hex–GM2–MGL2 maintains brain homeostasis - Nature Nature - Microglia–neuron crosstalk via Hex–GM2–MGL2 maintains brain homeostasis

Our brains rely on microglia—they deliver the lysosomal enzyme β-hexosaminidase to neurons to clear toxic GM2 buildup.

And transplanted microglia-like cells can rescue neurodegeneration. Just published in Nature! 🧠

🔗 www.nature.com/articles/s41...

07.08.2025 17:12 — 👍 4    🔁 1    💬 0    📌 0

Join our "Advances in Single-Cell Technologies" meeting in December in Freiburg, co-organised with Marco Prinz and @katrinkierdorf.bsky.social. Excellent line-up of speakers covering spatial technologies, lineage tracing, computational methods, and more.
www.uniklinik-freiburg.de/single-cell-...

21.07.2025 06:15 — 👍 18    🔁 13    💬 0    📌 1

Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease - Nature Neuroscience The dynamics of microglia states adjacent to or far from amyloid-beta plaques are unclear. Here the authors show that non-plaque-associated microglia modulate the cell population expansion in response...

Characterizing plaque-associated #microglia (PAM) and non-plaque-associated microglia (non-PAM) in a mouse model of Alzheimer's disease; non-PAM modulate cell population expansion in response to amyloid deposition and rapidly respond to environmental cues

www.nature.com/articles/s41...

15.07.2025 16:26 — 👍 9    🔁 2    💬 0    📌 1