Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures Gliomas respond poorly to therapy and are considered immunologically “cold” tumors. Cakmak et al. identify tertiary lymphoid structures (TLSs) in a subset of gliomas that show signs of functional adap...

Frankfurt Gang is rockin it again!

www.cell.com/immunity/ful...

@imkeller.bsky.social

Glioma‑associated microglia and macrophages as a potential target for mTOR inhibition in glioblastoma Glioma‑associated microglia/macrophages (GAM) constitute the predominant immune cell population in glioblastoma (GB). Both GB cells and GAM exhibit upregulated mTOR signaling. The present study aimed ...

Glioma‑associated microglia and macrophages as a potential target for mTOR inhibition in glioblastoma

www.spandidos-publications.com/10.3892/mmr....

So very much fascinating to see your own brain upon MRI.
I´m so incredibly excited about it, and do not mind at all to share it simply EVERYWHERE ! :) :) :)

#brain #mri #brainmri #humanbrain

😂😂🤩

Beautiful cover, beautiful meeting.

What an amazing meeting!
Great speakers, fantastic science and discussions, lovely people and... Amazing food!
#warschau #warsaw #braintumor

man sollte auch einfach direkt zum Ende der Schulzeit schon mit dem ersten Paper anfangen.......

Regulating the fate of tumor-associated macrophages Tumor-associated macrophages (TAMs) are key players in tumor progression, yet their role in this process remains only partially understood. In this issue of Cancer Cell, Sheban et al. demonstrate that zinc finger E-box-binding homeobox 2 (ZEB2) acts as a master regulator that reprograms TAMs toward a pro-tumor phenotype and that therapeutic targeting of ZEB2 exhibits anti-tumor activity.

Online Now: Regulating the fate of tumor-associated macrophages

Brain metastasis: From etiology to ecotypes Despite recent advances in anti-cancer therapies, metastasis, especially to the brain, represents a major clinical challenge with rising incidences. In this issue of Cancer Cell, Xing et al. present a comprehensive transcriptomic map of the metastatic brain tumor environment at single-cell resolution.

Online Now: Brain metastasis: From etiology to ecotypes

Neoadjuvant triplet immune checkpoint blockade in newly diagnosed glioblastoma - Nature Medicine A patient with newly diagnosed glioblastoma was safely treated with neoadjuvant nivolumab, relatlimab and ipilimumab before maximal resection, with comprehensive immune profiling showing the induction...

Despite low n number, this truly gives some hope!
In time for #ukbraintumorawareness month.

www.nature.com/articles/s41...

NOW.. also available here.
:)