Mario Brameshuber

Lukas, Barbora and Mario standing in front of a poster.

Lukas, Barbora and Mario in the Linz yellow train.

Nice to be back at the 25th (!) #Linz Winterworkshop with part of my great team. Excellent talks today by Ralf @jungmannlab.bsky.social , Alberto Diaspro, Thomas Schmid and many more

01.02.2026 15:37 — 👍 1    🔁 0    💬 0    📌 0

Refractive Index Mapping below the Diffraction Limit via Single Molecule Localization Microscopy Single molecule localization microscopy (SMLM) is a powerful method to image biological samples in three dimensions, below the diffraction limit of light microscopy. Beyond the position of the emitter...

In our second study led by Gerhard and Alex @i-med.ac.at , Simon, Lukas, Anna and co-workers used #SMLM combined with #AFM to map the refractive index along single collagen fibrils: pubs.acs.org/doi/10.1021/...

23.01.2026 08:41 — 👍 0    🔁 0    💬 0    📌 0

Quantitative Mapping of the Lipid Nanoenvironment around Transmembrane Proteins in Living Cells Weak and transient lipid–protein interactions are thought to shape plasma membrane organization and function but have largely eluded experimental characterization. While model systems can only capture...

...hence challenging the functional role of boundary lipids. Using a #micropatterning approach combined with #singlemolecule #tracking they could not observe the presence of tightly associated boundary lipids for 3 out of 4 studied proteins. Open access here: pubs.acs.org/doi/10.1021/...

23.01.2026 08:41 — 👍 0    🔁 1    💬 1    📌 0

Perfect start in 2026 with two publications in ASC nano @pubs.acs.org from or Biophysics team🎉

Veronika, Marina and co from Eva's team tried to answer the question "To what extent does a transmembrane protein influence, by its mere presence, the fluidity of its immediate lipid nanoenvironment?"...

23.01.2026 08:41 — 👍 0    🔁 0    💬 1    📌 0

PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Excited to share that our study, on how T cells selectively sense foreign antigens with single-molecule sensitivity, is out! This work was led by the brilliant Will White, and done in collaboration with Jay Groves and David Baker @uwproteindesign.bsky.social

www.pnas.org/doi/10.1073/...

07.06.2025 20:05 — 👍 21    🔁 6    💬 2    📌 0

Microdevice for confinement of T-cells on functionalized bio-interfaces Mechanical stimuli are an integral part of the natural cellular microenvironment, influencing cell growth, differentiation, and survival, particularly in mechanically challenging environments like tum...

I am happy to share our latest research on the development of a #squeezing device to study the compression of #Tcells in an antigen presenting cell #APC mimicking mechanoenvironment. Great work by talented PhD student Christoph!!
link to free advanced article pdf :
pubs.rsc.org/en/content/a...

02.05.2025 05:06 — 👍 4    🔁 0    💬 0    📌 0

BiaPy: accessible deep learning on bioimages - Nature Methods Nature Methods - BiaPy: accessible deep learning on bioimages

🙏 Thanks to
@naturemethods.bsky.social, @ritastrack.bsky.social, the reviewers, and the awesome bioimage analysis community.
We can't wait to see what you build with BiaPy! 🚀🧠
🔗 www.nature.com/articles/s41...
#BiaPy #BioimageAnalysis #DeepLearning

29.04.2025 09:33 — 👍 21    🔁 5    💬 0    📌 1

Please share our search for a PhD and PostDoc in Eva's group @tuwien.at . Deadline April 31st.

13.04.2025 11:22 — 👍 1    🔁 0    💬 0    📌 0

Open PhD/PostDoc Positions in #Biophysics

#PostDoc and #PhD position in Designing Synthetic Antigen-Presenting Cells for T-cell Antigen Recognition, Sevcsik lab, TU Wien (Vienna, Austria) closing: 31-April-2025 #Immunobiophysics #job www.tuwien.at/en/phy/iap/b...

04.04.2025 07:08 — 👍 1    🔁 0    💬 0    📌 1

Deeply saddened by the passing of Prof. Mike Sheetz, a true leader in Mechanobiology. His groundbreaking work on Kinesin, membrane organization, and mechanotransduction has left an indelible mark. A tremendous loss to science. #Mechanobiology #Science #LaskerAward

01.02.2025 11:29 — 👍 107    🔁 33    💬 3    📌 7

If you have a passion for single-molecule super-resolution microscopy🔬, there are great news to share: the SMLMS conference series will continue this year and will be held in Bonn/Germany Aug 27th to 29th ✨- please save the date and join us, we are looking forward to meeting you there👇🏻

15.01.2025 08:44 — 👍 18    🔁 4    💬 0    📌 0

Congrats @jonasries.bsky.social !!!!!

23.01.2025 11:06 — 👍 2    🔁 0    💬 0    📌 0

We made a photoswitchable HaloTag (psHaloTag), which can reversibly turn-on fluorogenic dyes upon illumination 💡. Congrats to Franzi, Bego and all co-authors, check out our preprint below 👇
www.biorxiv.org/content/10.1...

07.01.2025 08:45 — 👍 206    🔁 52    💬 2    📌 2

Life Sciences - Wiener Wissenschafts-, Forschungs- und Technologiefonds Life Sciences

900k WWTF #LS24 pre-Christmas gift for our group's (recently tenured) Eva Sevcsik: Together with Stefan Baudis #TUwien and Johannes Huppa #Charité she will design synthetic antigen-presenting cells to determine the 3D nanoenvironment of T-cell antigen recognition🔬 . 🎉 👏 ✌️ www.wwtf.at/funding/prog...

22.12.2024 14:45 — 👍 0    🔁 0    💬 0    📌 0