@dimovalab.bsky.social
News from Dimova Lab (www.dimova.de). Research: #membrane biophysics, #condensated, #electroporation, #syntheticbiology, minimal cell, #giantvesicles. Opinions are of RD
Thrilled and deeply humbled! 🙏
Honored to receive the Avanti/EBSA Award for pioneering work on giant vesicles at the #EBSA Congress in Rome.🏆
This award goes to my group–so grateful for their hard work! 🧪✨
Thanks to Avanti Research & @mpici.bsky.social for the amazing support!
Long live #GUVs!
Our doctoral candidate Matilde presented a poster on "Light-responsive asymmetric membranes" at the #EBSA2025 conference in Rome!
We're proud to see her contributing to the forefront of biophysical research! 🌟🧬🇮🇹
#MSCA #HorizonEurope #ComeInCell #DimovaLab
🤩 Sakshi Barhai has just joined #ComeInCell.
She will work on DC02 at @dimovalab.bsky.social and explore the stability and mechanical behavior of membranes in contact with biomolecular condensates using #GUVs. More details: www.comeincell.org/dc02-explori...
Welcome, Sakshi!
And huge thanks to our sponsors:
abberior Instruments GmbH • Ernst Rudolf Schloeßmann Foundation • @dfg.de • @jcellsci.bsky.social • @lipotype.bsky.social • @naniontech.bsky.social • @picoquant.bsky.social • Refeyn Ltd.
See you in Berlin!
@mpici.bsky.social @ewerslab.bsky.social
biomembrane-days-2025.mpikg.mpg.de
📢 Registration is open for the Biomembrane Days 2025!
🔗 biomembrane-days-2025.mpikg.mpg.de
A top-notch lineup of speakers, 120 posters, 200 scientists.
📜Submit an abstract by July 14
🏆3 Poster prizes
⚠️Limited spots-previous events were fully booked!
#BiomembraneDays2025 #Biophysics #CellMembranes
Let's get an update on @comeincell.bsky.social, the MSCA doctoral network that aims to develop advanced cellular mimics to shed light on complex cellular mechanisms and accelerate innovation. We interviewed Rumiana @dimovalab.bsky.social, the consortium's coordinator
syntheticcell.eu/update-on-co...
Poster session = a blast! Great science, good laughs, and old friends like @labrobinson.bsky.social.
Bonus: conference dinner featured Félix Goñi singing & an asymmetry song with Georg Pabst & John Seddon! At the library of the RSC Burlington House
#FaradayDiscussion #MembraneAsymmetry #ScienceVibes
Enjoying the Faraday Discussions on Membrane Asymmetry in London-great science 🤩, thought-provoking talks, & excellent discussions on the many facets of membrane structure & function. Grateful to be part of this community!
www.rsc.org/events/detai...
#FaradayDiscussion #MembraneAsymmetry #Biophysics
the ERC has added a million euro for researchers moving to Europe.
18.04.2025 01:56 — 👍 152 🔁 77 💬 4 📌 12Link to original work @naturecomms.bsky.social : doi.org/10.1038/s414...
08.04.2025 11:57 — 👍 7 🔁 1 💬 0 📌 0During her three-month visit in 2022, Emi worked on #biomimetic #bacterial #membranes, leading to a well-rounded publication: (doi.org/10.1016/j.bb...).
It’s inspiring to see Emi openly sharing her experiences and perspectives on disabilities in science 🤩
#ScienceForAll #Inclusion #DiversityInSTEM
Very proud to have hosted Emi in our lab and worked with her!
@mpici.bsky.social @potsdamsciencepark.bsky.social
www.nature.com/articles/d41...
Join now for the German society for cell biology lunch seminar on membrane organization and contact sites:
us06web.zoom.us/j/9617810697...
❓What happens when biomolecular #condensates interact with their membrane-bound neighbors in #cells❓
@mangiarotti.bsky.social & @dimovalab.bsky.social's finding: more tightly packed lipids in #membranes repel condensates; loosely packed ones attract them
#Biochemistry #ChemSky
tinyurl.com/58uuv5ep
I was invited, for July, to a scienctific meeting in Telluride (Colorado). I was told it is a wonderful place for a conference, and I was very much looking forward to an exciting meeting in a fantastic environment. I have just canceled my participation, despite having booked already everything.
23.03.2025 10:44 — 👍 69 🔁 23 💬 4 📌 48/8 Huge thanks to Agu @mangiarotti.bsky.social, Elias Sabri, Kita Schmidt, Christian Hoffmann, Drago Milovanovic & Reinhard Lipowsky for their great work on this! 🎉🎉🎉
@mpici.bsky.social @potsdamsciencepark.bsky.social
7/8 🔬 Key findings:
✅ Loosely packed membranes attract condensates
❌ Tightly packed membranes (higher lipid saturation, cholesterol) repel them
🌀 Condensates and protein adsorption actively remodel membranes, forming tubes & double-membrane sheets
Check out the full study here:
rdcu.be/eelLq
6/8 A side note: adsorption of membrane nanotubes onto condensate can also transform them into double-membrane sheets (i.e. flat vesicles).
bit.ly/4kI3k0l
5/8 But that’s not all! Condensates don’t just bind-they also make membranes tubulate. We knew that already(bit.ly/4itKMj2), but now we also see that protein binding transforms tubes into double-membrane sheets at the vesicle surface.🌀 This remodeling could have implications for organelle dynamics!
21.03.2025 08:46 — 👍 0 🔁 0 💬 1 📌 0
Under the microscope we see 3 contact angles (and they differ from vesicle to vesicle in the sample). They are apparent as the membrane cannot exhibit a kink. From them one can calculate the real (intrinsic) contact angle
4/8 When you characterize affinity/wetting, watch out 👀! Measure not just 1️⃣ microscopic contact angle (note that microscopic contact angles differ from vesicle to vesicle). Measure all 3️⃣ of them to give you the real (intrinsic) contact angle.
Check also previous work 📖: link.aps.org/abstract/PRL...
3/8 So, when a condensate droplet 💧 meets a Janus vesicle with 2 phases - say liquid ordered and liquid-disordered - it avoids the ordered/tightly packed domain and spreads on the disordered, less packed one.
You can finely map lipid packing with hyperspectral imaging &phasor analysis bit.ly/4bvw5IO
2/8 We found that membrane lipid packing-not just phase-determines interaction. Condensates favor loosely packed membranes and avoid tightly packed ones.
👉 Higher lipid packing (longer/saturated chains, cholesterol) → lower condensate affinity 🚫
👉 Lower lipid packing → higher condensate affinity ✅
1/8 Exciting new work with Agu @mangiarotti.bsky.social @mpici.bsky.social ! 🚀 Our latest study explores how lipid packing and cholesterol regulate the interaction of biomolecular condensates with membranes. It turns out, it’s not just about membrane phase. Packing is the key! 🧵👇
rdcu.be/eelLq
😎 Excited to welcome Matilde to the @dimovalab.bsky.social as part of our #MSCA Doctoral Network!
She'll be working on the DC01 project, exploring asymmetric GUVs and their interactions with biomolecular condensates.
Welcome aboard, Matilde! 🚀
#DoctoralCandidate #ComeInCell #HorizonEurope
Great! 👍
28.02.2025 09:16 — 👍 0 🔁 0 💬 0 📌 0That might be difficult as the membrane should not exhibit a kink at molecular scale... I think it suffices to discuss it in the text. Congratulations on this extensive work!
28.02.2025 09:01 — 👍 0 🔁 0 💬 1 📌 0I like your cartoon 😊 One small comment - because membranes are so soft, sessile droplets most of the time deform them and they are no longer planar. Just a detail, important mainly to membrane aficionados.
28.02.2025 08:18 — 👍 0 🔁 0 💬 1 📌 0They will be happy to have you 😊
26.02.2025 13:29 — 👍 1 🔁 0 💬 0 📌 0
📢 SAVE THE DATE: Sept 29 - Oct 1, 2025
and come to Berlin to the
BIOMEMBRANE DAYS
Excellent line of speakers and slots for contributed talks.
Registration will open in Spring.
biomembrane-days-2025.mpikg.mpg.de
Organized by Helge@ewerslab.bsky.social Thomas Weikl and myself
@mpici.bsky.social
Going on now at #BPS2025
The Best of BJ Symposium
@biophysicalsoc.bsky.social
EFFECT OF LEAFLET ASYMMETRY ON THE STRETCHING ELASTICITY OF LIPID BILAYERS WITH PHOSPHATIDIC ACID
Rumiana Dimova
👏👏👏👏👏👏
l.core-apps.com/bpsam2025/ev...
