A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?
Excited to share our latest work in @science.org on a new small polymerase.
1/n
13.02.2026 11:42 — 👍 480 🔁 199 💬 10 📌 25
New paper from my group in @science.org : "A small polymerase ribozyme that can synthesise itself and its complementary strand" www.science.org/doi/10.1126/...
Outstanding work by @edogia.bsky.social
13.02.2026 10:57 — 👍 149 🔁 37 💬 1 📌 5
Sounds exciting, right??
PhD positions at KCL & Leeds are available through our new EB4BM: Engineering Biology for Biomedicine doctoral training program!
eb4bm.org/project/engi...
eb4bm.org/project/stru...
06.02.2026 17:04 — 👍 0 🔁 0 💬 0 📌 0
📢2025 RSC Chemical Biology Emerging Investigators collection is now published online.
This collection features invited contributions from early career researchers who are making significant contributions to the field of chemical biology.
➡️Read the full collection here: https://rsc.li/cbemi25
17.12.2025 14:30 — 👍 0 🔁 1 💬 0 📌 0
Sources of mismeasurement of RNA knockdown by DNAzymes and XNAzymes
RNA-cleaving olignucleotide catalysts composed of DNA and/or nucleic acid analogues (DNAzymes, modified DNAzymes and XNAzymes) are promising agents for specific knockdown of disease-associated RNAs. H...
New paper online! In a distillation of years of painful lessons we've learnt exploring applications of RNA-cleaving DNAzymes as agents for knockdown in cells, we showcase the troubling variety of ways that false positives & negatives can creep in - and how to avoid them. pubs.rsc.org/en/Content/A...
08.09.2025 11:10 — 👍 3 🔁 1 💬 0 📌 0
Group Leader at MRC Laboratory of Molecular Biology. Transcription, RNA Polymerase II, Ubiquitin
A gold open-access journal focused on innovative chemical biology tools and their application in exploring and manipulating molecular biological processes.
🌐 Website: rsc.li/rscchembio Published by @rsc.org
PhD student in inorganic/materials chemistry at KCL and hobby harpist!
I love all things science (but especially nanoscale metal sulfides)
Molecular biologist. Group leader at MRC LMB Cambridge UK. Fellow at Clare Hall college. #CryoEM #RNAbiology #DNArepair
Views/opinions are my own.
https://www2.mrc-lmb.cam.ac.uk/group-leaders/n-to-s/lori-passmore/
Group Leader @MRC_LMB /Structural Biologist/Biochemist. Amateur baker in free time #RNAworld #spliceosome #telomerase #telomeres #cryoEM #Xraycrystallography
Organic chemist interested in the origins of life. Moranlab.com
🇨🇦 CRC1 and Prof @uottawa.ca
🇫🇷 part-time @unistra.fr
Senior Lecturer at the University of York. DNA, protein-DNA, biophysics, modeling, supercoiling, and much more
We develop Optimer® binders to enable innovation across research, diagnostics, therapeutics and bioprocessing.
Solve Biology
Head of Generative Genomics, Wellcome Sanger Institute, Cambridge, UK
Systems + Synthetic Biology, CRG, Barcelona
http://barcelonacollaboratorium.com http://allox.bio https://www.sanger.ac.uk/programme/generative-and-synthetic-genomics/
Excited to engineer a synthetic cell from scratch with lipid vesicles and DNA/RNA origami-based molecular hardware. Professor @ZMBHh @UniHeidelberg
The MRC Laboratory of Molecular Biology aims to understand biological processes at the molecular level to help tackle human health problems and disease.
Medical research non-profit transforming promising life science ideas into medical breakthroughs that change patients’ lives.
Program Leader and Head of PNAC division at MRC Laboratory of Molecular Biology, Cambridge, UK @mrclmb.bsky.social. Synthetic / Chemical biology and all things RNA
Cryo-EM ❄️🔬 | Molecular machines & mechanisms 🧬 | Associate professor @oxfordbiochemistry ghilarovlab.com
Executive Editor/Team Lead Open Access Science & Medicine Journals Sage Publishing
Opinions = mine
http://linkedin.com/in/jlovick-editor
#oncology #cancerresearch #medicine #biology #cardiology #neurology #microbiology #publichealth #healthcare
Structural biology and Biophysics at the University of Nottingham and Research Complex at Harwell (UK).
Academic and writer of papers and grants with modest success.
Happy collaborator and always available to chat science.
He/him.
Associate Professor @OIST, our group is interested in understanding the origin of protein function. mom, climber, skier
Science journalist covering all fields. Formerly an editor at New Scientist and Nature. Particular fan of health, exercise, mushrooms, amphibians and marine life 🧪🐸 🍄
Selection of articles here: https://www.newscientist.com/author/chris-simms/
Synthetic Biology. Designer cells and organelles. Space plants and microbes. Antifungal. Antimicrobials. Optimization of DNA delivery: conjugation, cell fusion. Western University, Canada.
Prof for Synthetic Biology at TU Dortmund University
Interested in: SynBio - RNA/ribozymes - cell free systems - protocells
