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Tomasz Kosciolek

@tomaszlab.bsky.social

Structural and Functional Genomics group Kraków, Poland Sano Centre for Computational Medicine

67 Followers  |  68 Following  |  2 Posts  |  Joined: 14.11.2023  |  1.2299

Latest posts by tomaszlab.bsky.social on Bluesky

We found that functional amyloids from the gut microbiome are more abundant in Parkinson's patients but not in Alzheimer’s. These amyloids interact with human proteins, potentially triggering inflammation and impacting signaling. [2/2]

05.12.2024 15:12 — 👍 0    🔁 0    💬 0    📌 0
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Aggregating gut: on the link between neurodegeneration and bacterial functional amyloids Amyloids are insoluble protein aggregates with a cross-beta structure, which are traditionally associated with neurodegeneration. Similar structures, named functional amyloids, expressed mostly by mic...

How gut bacteria influence neurodegeneration? Learn how we were able to identify functional amyloids and establish a putative mechanism for the development of Parkinson's [1/2]

Our pre-print is out now!
📄 www.biorxiv.org/content/10.1...

05.12.2024 15:12 — 👍 2    🔁 1    💬 1    📌 0
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Exploring structural diversity across the protein universe with The Encyclopedia of Domains https://www.biorxiv.org/content/10.1101/2024.03.18.585509v1 The AlphaFold Protein Structure Database (AFDB) contains full-length predictions of the three-dimens

Exploring structural diversity across the protein universe with The Encyclopedia of Domains https://www.biorxiv.org/content/10.1101/2024.03.18.585509v1

20.03.2024 00:47 — 👍 4    🔁 2    💬 0    📌 0

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