Ana Maria Lopez, MD, MACP

Hello folks. I am glad to join you here on Bluesky!

Karine Jean-Pierre gives her final White House press briefing.

"I would not be here today if it were not for generations of barrier-breaking people before me. I have stood on their shoulders."

I'm gonna miss KJP.

www.thelancet.com/infographics...

Reimagining Cancer Care for Patients Experiencing Homelessness by Expanding the Traditional Oncology Team | JCO Oncology Practice

People experiencing homelessness experience challenges navigating complex health systems r/t competing priorities, poverty, medical & behavioral health problems & have ⬆️ rates of missed appointments and ED visits after diagnosis @ascocancer.bsky.social #cansky
ascopubs.org/doi/full/10....

Thank you~

God bless Jimmy Carter and Joe Biden.

Two fundamentally decent men. ♥️

How wonderful to come across this spotlight!! Thank you @LouLanza for all you do! @NCCS @SidneyKimmelCancerCenter

Great tradition!! Best holiday wishes!
cid:F5DA1033-AECB-4ECA-9FBC-B992FCEE9B11

Just listened to @SyMontgomery on @livingonearth @npr.org on learning from nature, learning from other sentient beings, beautiful reflections. Thank you!

⚠️ #MedSky public service announcement: if you/your family are among the ~60% of eligible Americans who haven’t yet had the 2024-25 flu shot, it’s time. Influenza A is 🚀 nationwide in wastewater (via @BiobotAnalytics). CDC recommends #FluShot for age 6 mos & up.

Two cups of hot cocoa, one is much wider at the top and both are filled with mini marshmallows

If you use a shorter, wider mug you can have as much cocoa and 3x the marshmallows

Follow me for more life hacks

This

A large butterfly perched on rabbitbrush, a fuzzy looking yellow flower

It's year-end so I'm rounding up new species I saw in 2024. This is an Arizona Sister (Adelpha eulalia). This was on my target species list when we took a trip to Mesa Verde NP in southwestern CO. It took about 2 minutes to find several enjoying the rubber rabbitbrush. They are large and stunning!

#POTS #LongCovid #EDS #MCAS #ChronicIllness #DisabilityRights #Spoonie

Fox standing in the snow.

Good morning from @altyellonatpark.org

🧪Incredible story of the triumph of science and humanity. Neil Willenson founded the camp in the early 90s at the age of 22‼️

#MedSky I'm not sure anyone in the late 80s or early 90s imagined a day like this would come.

Follow this account for a most excellent timeline cleanse, a guaranteed smile, and solid info on childhood development.

Thanks, @danwuori.bsky.social

Poor vascular health accelerates brain ageing Using an AI tool, researchers at Karolinska Institutet have analysed brain images from 70-year-olds and estimated their brains’ biological age. They found that factors detrimental to vascular health, ...

Using an AI tool, researchers Anna Marseglia, Eric Westman, et al. "have analysed brain images from 70-year-olds and estimated their brains’ biological age."

Learn More:
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Overview from Karolinska Institutet:
news.ki.se/poor-vascula...

In a really interesting post holiday convo tonight

A question coming out of it for me is :

Are the thoughts &acts of OTHERING just part of human 🧬 DNA?

#medsky, #primarycaresky it’s core to the social and political determinants of health and to the persistence of non universal care, so .. 🤔

#medsky
@##&@
Nephron IS a word.
Grrr

Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain Systemic delivery of large nucleic acids, such as mRNA, to the brain remains challenging in part due to the blood-brain barrier (BBB) and the tendency of delivery vehicles to accumulate in the liver. Here, we design a peptide-functionalized lipid nanoparticle (LNP) platform for targeted mRNA delivery to the brain. We utilize click chemistry to functionalize LNPs with peptides that target receptors overexpressed on brain endothelial cells and neurons, namely the RVG29, T7, AP2, and mApoE peptides. We evaluate the effect of LNP targeting on brain endothelial and neuronal cell transfection in vitro, investigating factors such as serum protein adsorption, intracellular trafficking, endothelial transcytosis, and exosome secretion. Finally, we show that LNP peptide functionalization enhances mRNA transfection in the mouse brain and reduces hepatic delivery after systemic administration. Specifically, RVG29 LNPs improved neuronal transfection in vivo, establishing its potential as a nonviral platform for delivering mRNA to the brain.

Breakthrough Research! @upenn.edu Bioengineers Emily Han, Michael Mitchell, et al. have modified lipid nanoparticles (LNPs) to not only cross the #BloodBrainBarrier (BBB) but also to target specific types of cells, including neurons.

Learn More in Nano letters
pubs.acs.org/doi/10.1021/...

I have always loved public libraries, but having young children has exponentially increased my gratitude and sense of indebtedness to them. Our local library is such a huge part of our lives. The books, the programming, the very intentionally curated kids’ section. It’s all such a gift.

Has been a fun/crazy Christmas with a full house- family joy (and too many dogs staying out of the rain).
Sending peace, love and hope to all out in .blsky land! Hope you are all vaccinated and in good health as we ride through the holiday season and into 2025!!

Whooping cough cases continue to surge in US, reaching highest level in a decade.

#IDSky
#Pertussis

wonder.cdc.gov/nndss/static...

This IDWeek 24 session is a great resource to understand what is happening (and has been happening!) in US Farms.
If u registered for it then u can watch it.

Not sure if @idsainfo.bsky.social ever releases content for free after the conf, but should consider making this available.
#IDSky #EpiSky

First overnight on service in a while…. Influenza is here with a vengeance and it’s no coincidence that anti-vaccine culture is too. 🤔 Time to counsel and educate. It’s the most important thing (and sometimes
the only thing) we can do in these situations.
#medsky #idsky

Ending a glorious Sunday outdoors! Did not get on the bike today but plenty of yard-focused crop training! Hope you are all -as I am- rejuvenated and ready for another week of service. Show respect and love to all.

Take a look back at #SABCS24! Thank you to the co-directors, executive committee, program planning committee, speakers, and attendees for making this year's symposium a tremendous success.

@uthealthsamda.bsky.social @theaacr.bsky.social