Mitchell Dumais, MD

My 2025 Epic Wrapped just dropped:
- 3,817 preop chart reviews
- 924 Chat messages
- 3,036 EKGs reviewed
- 121 PACU order addendums
- Top song: “Monitor Not Linked to Charting”
- Top artist: Cardiology Clearance and the Echos
- Top alert: “Did you mean to order that drug?”

So happy to have you!! Congratulations!

Interactive AIDS Quilt The National AIDS Memorial, through a partnership with the AIDS Quilt Touch team, presents all 48,000 panels of the AIDS Memorial Quilt in an interactive experience People around the world can experie...

“The National AIDS Memorial, through a partnership with the AIDS Quilt Touch team, presents all 50,000 panels of the AIDS Memorial Quilt in an interactive experience so people around the world can experience the beauty of the Quilt and witness the love and stories stitched into each panel.”

ID Things to Be Grateful for -- 2025 Edition Looking back on these annual Thanksgiving posts, I notice an odd pattern: every few years, the intro turns into a kind of apology. As in, Yes, I know the title sounds upbeat, please don’t attack me. T...

Can we really be grateful for anything in the ID world in 2025?

Sure -- plenty of great advances!

Here are a half-dozen to celebrate (and be grateful for) in 2025, believe it or not. #idsky
blogs.jwatch.org/hiv-id-obser...

A New Flu Variant May Make Cold Season Brutal This Year U.S. flu rates remain low, but experts are keeping an eye on a new strain that’s been linked to unexpectedly early and severe seasons in several other countries

Got the flu last year on Thanksgiving and it really sucked. Obviously vaccine is no guarantee you won’t get it, but it’s basically free with no downside and is, imho, a no-brainer.

www.scientificamerican.com/article/how-...

Washington state resident dies of new H5N5 form of bird flu The person, who lived in Grays Harbor County, Wash., had been hospitalized earlier this month in Kings County, where Seattle is located.

Washington state resident dies of new H5N5 form of bird flu

Unexpected events and prosocial behavior: the Batman effect - npj Mental Health Research npj Mental Health Research - Unexpected events and prosocial behavior: the Batman effect

Not the Science we need, but the Science we deserve.

"Passengers were significantly more likely to offer their seat when Batman was present (67.21% vs. 37.66%, OR = 3.393, p < 0.001)." More people offered their seat with Batman present, even if they didn't see him.

www.nature.com/articles/s44...

More countries report rising levels of drug-resistant gonorrhoea, warns WHO The World Health Organization (WHO) warns that gonorrhoea, a sexually transmitted infection, is becoming increasingly resistant to antibiotics, according to new data from its Enhanced Gonococcal Antim...

“Between 2022 and 2024, resistance to ceftriaxone and cefixime, the primary antibiotics used to treat gonorrhoea, rose sharply from 0.8% to 5% and from 1.7% to 11% respectively, with resistant strains detected in more countries… resistance to ciprofloxacin reached 95%.”

Ethiopia confirms first outbreak of Marburg virus disease Ethiopia’s Ministry of Health has confirmed an outbreak of Marburg virus disease in the South Ethiopia Region, the first of its kind in the country, following laboratory testing of samples from a clus...

The deadly fever in Ethiopia has been identified as Marburg disease.
It’s the first time a Marburg outbreak has been identified in Ethiopia.
#IDsky 🧪

www.afro.who.int/countries/et...

Doxycycline and amox-clav is the ID power couple

Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3 | NEJM Angiopoietin-like protein 3 (ANGPTL3) inhibits lipoprotein and endothelial lipases. ANGPTL3 loss-of-function genetic variants are associated with decreased levels of low-density lipoprotein cholest...

Gene therapies are on the cusp of changing how we manage certain chronic diseases. Soon, patients may have a choice between:
1. Daily medication 💊
2. Single injection 💉

Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3 | New England Journal of Medicine www.nejm.org/doi/full/10....

Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy - Nature Immunology Klein and colleagues characterize 04_A06, a new VH1-2-encoded broadly neutralizing antibody that has marked breadth and potency against extended multiclade HIV-1 pseudovirus panels and can maintain fu...

Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy | Nature Immunology share.google/FBKwDoY0t8rX...

"04_A06, a broadly neutralizing antibody ... with remarkable breadth and potency against multiclade pseudovirus panels (98.5%, 332 strains)"

Some viruses can play a deadly game of hide and seek inside the human body Ebola is one of the nasty viruses that can hide in the body even after a patient recovers and tests negative. It can reemerge and trigger a new outbreak years later. How do they survive? And how can they be kayoed?

Ebola is one of the nasty viruses that can hide in the body even after a patient recovers and tests negative. It can reemerge and trigger a new outbreak years later. How do they survive? And how can they be kayoed? n.pr/4hB9gXN

“We should be cautious not to apply AI indiscriminately as a solution in search of a problem... AI will not absolve us from making difficult ethical decisions, especially decisions concerning life and death.”

Protein Powders and Shakes Contain High Levels of Lead - Consumer Reports CR tests of 23 popular protein powders and shakes found that most contain high levels of lead.

my latest investigation for @consumerreports.org is based on months of reporting and 60+ lab tests of leading protein supplements

we found that most protein powders and shakes have more lead in one serving than our experts say is safe to have in a day (🧵)

www.consumerreports.org/lead/protein...

Association Between Apple Eaters and Physician Visits This cross-sectional observational study does not support that “an apple a day keeps the doctor away”; however, the small fraction of US adults who eat an apple a day do appear to use fewer prescripti...

Neat

“A study, published on Wednesday in the New England Journal of Medicine, showed that last season’s 2024–2025 mRNA COVID vaccines reduced people’s risk of emergency department visits by 29%, their risk of hospitalizations by 39% & their risk of death by 64%”

Benefits were seen even if 0 risk factors

RSV vaccines offer vital protection for the most vulnerable, study confirms A review of 14 clinical trials involving more than 100,000 participants supports widespread RSV vaccination to reduce severe illness and hospitalisations.

A new Cochrane review pooled >100,000 participants across 14 trials of RSV vaccines:
- In older adults,RSV vaccines ⬇️ RSV-related lower resp illness by ~70%.
- In pregnant people, vaccination halved the risk of infants needing medical care for RSV & ⬇️severe dz by ~74%.
www.gavi.org/vaccineswork...

Swapping old immune cells in the brain with fresh ones could treat disease Replacing immune cells called microglia holds promise for addressing brain conditions such as Alzheimer’s disease.

Replacing old immune cells called microglia with fresh ones holds promise for addressing brain conditions such as Alzheimer’s disease @nature.com @heidiledford.bsky.social
nature.com/articles/d41...

Antagonistic interaction between posaconazole and olorofim in a murine model of invasive pulmonary aspergillosis AbstractBackground. Olorofim is a new antifungal agent with a novel mechanism of action with in vitro activity against Aspergillus fumigatus and other clin

Antagonistic interaction between posaconazole & olorofim in a murine model of invasive pulmonary aspergillosis

Posaconazole ⬇️ the effect of olorofim in vivo. Combination of olorofim+azole likely efficacious in wt infections, may be suboptimal in azole R infections

academic.oup.com/jac/article/...

Philanthropies Strike a Promising Deal to Turn Back H.I.V. Low- and middle-income countries will be able to purchase an effective preventative at a reduced price. The arrangements may help stem the epidemic 40 years after it began.

A drug that provides near-perfect protection against HIV with shots just twice a year will be made available at $40 per patient annually in low- and middle-income countries, offering new hope for ending the epidemic.

Clinical and microbiologic features of Achromobacter species: a 10-year, multicenter experience | Journal of Clinical Microbiology Achromobacter is a rare but important genus of bacteria that tends to cause infection in those with cystic fibrosis, recurrent healthcare exposures, and/or an immunocompromising condition. There is li...

An excellent project that came together from my time during residency - a great analysis of this difficult bug 🦠!

Clinical and microbiologic features of Achromobacter species: a 10-year, multicenter experience | Journal of Clinical Microbiology journals.asm.org/doi/10.1128/...

"bUt tHe WhiTe cOuNT iS nOrmAL"

I see this pattern of laboratory evaluation almost every day in the ICU

anyone involved in evaluating acutely ill patients must be able to recognize this evolution, like the face of an old friend

what is going on here? #EMIMCC 🧵 #1/5

Health care costs are soaring. Blame insurers, drug companies — and your employer Some 154 million people in the United States get health care through their employer — and for many, their costs are about to go way up.

Some 154 million people in the United States get health care through their employer — and for many, their costs are about to go way up.

Child dies from rare measles-related complication, LA County health officials say Health officials reported the death of a Los Angeles County child from a complication of measles infection acquired during infancy.

Death from sub-acute sclerosing panencephalitis (SSPE) in a child in Los Angeles
SSPE is a rare sequel of #measles infection that appears years after the initial infection, and is uniformly fatal. So sorry for this family. As things are going on the US, we'll be seeing more of these cases.

Bluesky now platform of choice for science community It’s not just you. Survey says: “Twitter sucks now and all the cool kids are moving to Bluesky”…

Good to see @bsky.app has emerged as the social media platform of choice for science stuff
arstechnica.com/science/2025...

The U.S. confirms its first human case of New World screwworm. What is it? U.S. officials confirmed a case of the flesh-eating parasite in a person who traveled from El Salvador. Screwworm typically affects cattle in South America, but has spread north in recent years.

I studied infectious diseases because I get bored easily and needed to be in a field in which there is never a dull moment. The US just confirmed its first human case of myiasis in many decades in a returning traveller from El Salvador.
www.npr.org/2025/08/25/n...

Its honestly growing on me - every time I see it I like the design more

Me, signing up for yet another conference with free food