Rosetta Commons

Introducing Deep-Learning–Designed Macrocycles: High-Affinity Protein-Binders Members of the IPD: Gaurav Bhardwaj, Frank DiMaio, and 2024 Nobel laureate David Baker have unveiled a deep-learning framework capable of the de novo design of macrocyclic peptides that bind protei…

Members of IPD: Gaurav Bhardwaj, Frank DiMaio, and 2024 Nobel laureate David Baker have unveiled a deep-learning framework capable of de novo design of macrocyclic peptides that bind proteins with nanomolar affinity and remarkable precision.
Read more: rosettacommons.org/2025/06/26/i...

Registration for the Biomolecular Modeling and Design with Rosetta and ML Tools Workshop (November 17–19, 2025) is now open. The goal of the workshop is to educate and train academic and industry users on the Rosetta software suite.

Explore more: meilerlab.org/tutorials/

We're excited to introduce our #RaMP 2025-2026 cohort. Watch this space for more updates.

It should be working now!

RFdiffusion: Beta Documentation Now Available

We’re excited to announce that RFdiffusion now has official, Rosetta Commons-curated documentation! Read more: rosettacommons.org/2025/07/16/r...

Release v1.0.0 · ajasja/prosculpt What's new Prosculpt now easier to install -- uses containers! Prosculpt now easier to run on SLURM -- all SLURM (queue, number of tasks) info can be given in the prosculpt yaml file. What's Chan...

We listened to your feedback. Proscuplt is:
*Easier to install - now uses use containers 🚀
*Easier to run in SLURM - specify queue & task details directly in the prosculpt YAML file.

github.com/ajasja/prosc...

Big thanks to Federico Olivieri, Alina Konstantinova, Nej Bizjak, and Žan Žnidar🙏

Looking Ahead: What’s Changing for RosettaCons in 2026 As the Rosetta Commons community continues to grow, the Executive Board has been actively rethinking how we plan and structure our annual gatherings. The goal is to create events that are more sust…

We’re making a few intentional changes to our US-based Rosetta conferences next year to better support our growing community. We want to hear what you think.

Learn more about the changes: rosettacommons.org/2025/06/26/l...

Share your thoughts: docs.google.com/forms/d/e/1F...

Rosetta Commons Opens Applications for 2025 Biosecurity Fellow Rosetta Commons is now accepting applications for our next Biosecurity Fellow! This unique 12-month fellowship offers the opportunity to work at the intersection of computational protein design and…

RC Biosecurity Fellowship is accepting proposals: 12-month program offers a chance to shape how protein design tools are developed & governed. Fellows lead initiatives, engage with our labs & policy experts, & help bridge science and policy around biosecurity.
rosettacommons.org/2025/06/26/r...

All about Prosculpt by Ajasja Ljubetic Prosculpt is an open-source library that encapsulates RFDiffusion, ProteinMPNN, AlphaFold2, and Rosetta into an easy-to-use workflow. The input is a yaml file describing the prob…

News from the Rosetta community: Prosculpt – an open-source library integrating RFDiffusion, ProteinMPNN, AlphaFold2 & Rosetta into one easy workflow

More via @ajasjaljubetic.bsky.social : rosettacommons.org/2025/05/28/a...

We are very excited to announce that early bird registration for European RosettaCon 2025 is now open!

More information here: europeanrosettacon.org

Members of EU Rosetta Con 2024

Early bird registration for 𝐄𝐔 𝐑𝐨𝐬𝐞𝐭𝐭𝐚 𝐂𝐨𝐧 𝟐𝟎𝟐𝟓 is open! 🎉🎉🎉

Come join us for three days of protein design fun! (October 20-22, 2025)

Direct registration link: pretix.eu/SBD/RCon2025/
Website: europeanrosettacon.org

We are looking forward to seeing you!

Please share this far and wide:)

Summer RosettaCon 2025 registration will close this Sunday, June 1, at 11:59 PM EDT. Register now on RosettaCon.org.

This year, we have a new panel format for our talks, covering protein design with Rosetta and deep learning, as well as other modeling topics you're interested in, and much more!

Our Rosetta Commons Research Experience for Undergraduates (REU) students have completed the first leg of the program with the @jeffreyjgray.bsky.social lab at the Johns Hopkins University and are now heading to their host labs for the summer. Stay tuned for more!

How to train your model An advanced protein design Bootcamp / Hackathon software developer event Summer RosettaCon 2025 – Bootcamp / Hackathon – Application is open, apply here This immersive, hands-on event i…

How to train your model.

This immersive, hands-on, advanced-level event is designed for researchers who are ready to move beyond “out-of-the-box” machine learning models for protein design. Join us for this Summer RosettaCon 2025 workshop/hackathon, more here: rosettacommons.org/2025/05/30/h...

1-day Protein Design AI-Driven Design of Biologics: Hands-on Guide to Using State-of-the-Art ML Protein Models brought to you by the Rosetta Commons Summer RosettaCon 2025 Workshop. Applications are now open, apply her…

Consider joining us for the SRC2025's 1-day Protein Design: One-day novice-level course surveying popular tools and workflows for modern protein design with brief exploration of common applications including antibody design and binder design. rosettacommons.org/2025/06/03/1-day-protein-design/

1-day Protein Design Workshop @ SRC 2025 AI-Driven Design of Biologics: Hands-on Guide to Using State-of-the-Art ML Protein Models brought to you by the Rosetta Commons Event dates Sunday 8/3 1pm - 6 pm Monday 8/4 8am - 2 pm Event Locati...

One-day novice-level course surveying popular tools and workflow for modern protein design with brief exploration of common applications including antibody design and binder design: 1-day Protein Design Workshop. Register here: tinyurl.com/SRC25-worksh...

How to train your model Event dates Sunday 8/3 1pm - 10pm Monday 8/4 7am - 2pm Friday 8/8 9am-10pm Saturday 8/9 Travel Application Link This immersive, hands-on event is designed for researchers who are ready to move beyo...

Register for SRC25 Workshop (tinyurl.com/SRC25-worksh...) : How to train your model - This immersive, hands-on advanced-level event is designed for researchers who are ready to move beyond “out-of-the-box” machine learning models for protein design.

Come hang out with us — Registration for Summer RosettaCon 2025 is open! It will be held at Suncadia Resort in Washington from August 4 - 7, 2025. Register here: rosettacon.org

Welcome Rachel Clune and Hope Woods to the Open Rosetta Team! We are delighted to share the addition of two new members to the Open Rosetta team at OMSF. Please join us in welcoming Rachel Clune as our new Documentation Writer, starting on May 1, and Hope Woo…

Our team is growing! We are delighted to share the addition of two new members to the Open Rosetta team at OMSF. Please join us in welcoming Rachel Clune, Ph.D. as our new Documentation Writer and Hope Woods as our new Technical Product Lead.

Read more: rosettacommons.org/2025/05/15/w...

Summer RosettaCon 2025 – Registration open! We are pleased to announce that Summer RosettaCon 2025 will take place at Suncadia Resort in Washington from August 4 to 7, 2025. Registration is now open! The conference will start in the late aft…

We are pleased to announce that Summer RosettaCon 2025 will take place at Suncadia Resort in Washington from August 4 to 7, 2025. Registration is now open: rosettacon.org/registration/

Find details here: rosettacommons.org/2025/04/20/s...

We look forward to seeing you there!

Introducing Rosetta Commons Research Experience for Undergraduates (REU) 2025 We’re pleased to introduce the 2025 Rosetta Commons Research Experience for Undergraduates (REU) cohort. Interns in this REU program, which is hosted across multiple locations, engage in research u…

We received 613 applications—and now we’re proud to welcome 23 students to the 2025 Rosetta Commons REU! Read more about what they have to tell you about themselves and highlight their goals and interests:
🔗 rosettacommons.org/2025/04/11/i...

Announcing the new RC AlphaRed container designer to run AlphaRed. AlphaFold-initiated replica exchange protein docking is a pipeline to predict protein complex structures from sequences. Read more: github.com/Graylab/Alph...

Save the date: Summer RosettaCon 2025 will happen from Aug 4-7, 2025 in Cle Elum! Registration opening soon

New for 2025: SRC will feature thematic scientific panels (not individual submissions). If you're interested in organizing or joining a panel, please sign up here: tinyurl.com/SRC25-Panels

Winter RosettaCon 2025 brought together a community of 335 participants. The scientific organizers Anum Glasgow and Sergey Ovchinnikov created a program featuring 40 talks, showcasing research from academia, industry, and external participants.

Read more rosettacommons.org/2025/03/20/w...

BindCraft: one-shot design of functional protein binders Protein–protein interactions (PPIs) are at the core of all key biological processes. However, the complexity of the structural features that determine PPIs makes their design challenging. We present B...

BindCraft is a new AI de novo binder design tool from the Correia lab with 10-100% success rates. It's available today as an easy to use API using our API framework so you can deploy it in your own pipeline today.

Contact us at levitate.bio/contact to get started
www.biorxiv.org/content/10.1...

Postbaccalaureate RaMP: Research and Mentoring for Postbacs: Training Program in Biomolecular Structure Prediction and Design Apply Here! Application Guide The Rosetta Commons Research and Mentoring for Postbaccalur…

The RaMP program is still accepting applications till March 1, 2025. This one-year fellowship program is intended for students to gain research experience to succeed in PhD programs. Learn more here: rosettacommons.org/education/ra...

Calling all Rosetta Commons community,
This is a reminder that registration for Winter RosettaCon 2025 closes TOMORROW at 11:59 PM EST. You can register and find more information at www.winterrosettacon.org

Register now for a 10% sale on Workshop pricing. Join us in Boston Feb 24-26 for a Protein-Protein Interaction Design Workshop. This intensive, hands-on, 2.5-day boot camp is designed for industry professionals to master protein-protein interaction (PPI) design. winterrosettacon.org/workshop-2025/

Join us in Cambridge, Boston (Feb 24-26, 2025) for Designing Protein-Protein Interactions, a hands-on Rosetta Workshop Event. Led by Amrita Nallathambi (UNC-Chapel Hill, Kuhlman Group). Learn more: lnkd.in/g_2ErSGS

The Rosetta Commons Research Experience for Undergraduates (REU) program accepts applications until February 1, 2025. Apply now and participate in research using the Rosetta Commons software. Learn more here: rosettacommons.org/education/reu/

#REU #RosettaCommons #Undergraduateprogram