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Tom Elliot

@tom-elliot.bsky.social

Postdoc @WorboysLab.bsky.social @LydiaBeckeriii.bsky.social investigating how checkpoint receptors regulate T cell function

237 Followers  |  379 Following  |  2 Posts  |  Joined: 11.12.2024  |  1.6354

Latest posts by tom-elliot.bsky.social on Bluesky

The deadline for this PhD is fast approaching. We are looking for a promising synthetic chemist to make new chemical biology tools to learn more about nucleic acid interactions. This is a collaborative project with the Trowbridge Lab in @uomscieng.bsky.social. If interested, get in touch soon!

29.05.2025 15:30 โ€” ๐Ÿ‘ 2    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Really humbled to have been selected by @iuis-online.bsky.social for their rising stars initiative and to be given the opportunity to present at their Congress in Austria this year! ๐Ÿฅณ๐Ÿฅณ๐Ÿฅณ #immunosky ๐Ÿงช

22.05.2025 19:47 โ€” ๐Ÿ‘ 35    ๐Ÿ” 1    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 2
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Inhibitory TIGIT signalling is dependent on T cell receptor activation TIGIT is an immune checkpoint receptor that can signal via cytoplasmic ITT-like and ITIM motifs to regulate T cell function. The signalling molecules that mediate inhibitory TIGIT signalling in T cell...

Our latest research is now available as a pre-print at BioRxiv. We show that the immune checkpoint receptor TIGIT cannot signal in T cells without simultaneous TCR stimulation.

#ImmunoSky

www.biorxiv.org/content/10.1...

14.05.2025 07:50 โ€” ๐Ÿ‘ 34    ๐Ÿ” 12    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 2
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PD1 & Lag3 regulate TCR signal duration in tolerant CD4 T cells
โ€ขPD-1 & Lag3 exhibit layered control of CD4 T cell activation
โ€ขCo-blockade enhances NFAT-dependent TCR transcription
โ€ขNFAT inhibition reverses functional effects of anti-PD-1&Lag3
doi.org/10.1093/immadv/ltaf015
@imtadvances.bsky.social

12.05.2025 08:03 โ€” ๐Ÿ‘ 19    ๐Ÿ” 6    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0
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Now published @cp-iscience.bsky.social
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development

www.cell.com/iscience/ful...

11.04.2025 07:21 โ€” ๐Ÿ‘ 38    ๐Ÿ” 7    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 1
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Research Associate in Imaging Human Immunology:Oxford Road

Our lab has a postdoc position available to use super-resolution microscopy to understand how nanoscopic localisation of immune checkpoints dictates their function.

Please get in touch if interested in applying.

www.jobs.manchester.ac.uk/Job/JobDetai...

#ImmunoSky #Imaging #Microscopy

26.03.2025 16:15 โ€” ๐Ÿ‘ 14    ๐Ÿ” 23    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Research Associate in Breast Cancer Metastasis:CRUK Oglesby Cancer Research Building, 555 Wilmslow Road, M20 4GJ

New postdoc position in @frances-turrell.bsky.social lab. Great opportunity to join a new group, doing exciting work ๐Ÿงช

Get in touch if you want to chat about life in the lab (it's fab)!

www.jobs.manchester.ac.uk/Job/JobDetai...

#ImmunoSky

26.03.2025 08:46 โ€” ๐Ÿ‘ 3    ๐Ÿ” 5    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Super privileged to be working on such an interesting and important project!

Working out how tumour cell dormancy is regulated is critical to managing reawakening and mitigating this risk for patients. Watch this space for some exciting experiments ๐Ÿงช

#ImmunoSky #CancerResearch

20.02.2025 17:49 โ€” ๐Ÿ‘ 9    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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IL-7 promotes integrated glucose and amino acid sensing during homeostatic CD4+ Tย cell proliferation Interleukin (IL)-7 promotes Tย cell expansion during lymphopenia. We studied the metabolic basis in CD4+ Tย cells, observing increased glucose usage forโ€ฆ

Online now, our latest manuscript reporting findings on the metabolic basis of cytokine-driven CD4+ T cell expansion, assessed in vitro and during T cell proliferation following autologous stem cell transplantation.

www.sciencedirect.com/science/arti...

20.01.2025 13:13 โ€” ๐Ÿ‘ 40    ๐Ÿ” 9    ๐Ÿ’ฌ 5    ๐Ÿ“Œ 1
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Research Associate in Mucosal Immunology :Manchester

๐Ÿšจ The Menon lab is hiring a postdoc!

Interested in mucosal immunology? Come join our team to study lung-infiltrating B cell dynamics in COPD & other chronic lung diseases @ukri.org @lydiabeckeriii.bsky.social

Please help spread the word #ImmunoSky

www.jobs.manchester.ac.uk/Job/JobDetai...

16.01.2025 18:40 โ€” ๐Ÿ‘ 25    ๐Ÿ” 25    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 2

There's still time to apply for this postdoc position in our lab. Ideally suited to someone wanting to develop some independent research, we have lots of new projects to select from! #immunosky ๐Ÿงช

16.12.2024 11:03 โ€” ๐Ÿ‘ 21    ๐Ÿ” 26    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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PD-1 and Lag3 pathways converge to additively regulate TCR signal duration and NFAT-dependent transcriptional activity during early CD4+ T cell re-activation
www.biorxiv.org/content/10.1...

16.12.2024 03:30 โ€” ๐Ÿ‘ 11    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Really enjoyed being back in Birmingham for a day for my graduation โ˜บ๏ธ Feeling very grateful for the people that helped me through my PhD last few years

11.12.2024 15:04 โ€” ๐Ÿ‘ 9    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Hi Laura, please could I join your starter pack?

11.12.2024 11:36 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

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