Santosh lamichhane's Avatar

Santosh lamichhane

@santoshlamichhane.bsky.social

PI, Academy Research fellow, Docent (Adj. Prof.) UTU, Finland ๐Ÿ‡ซ๐Ÿ‡ฎ Born in ๐Ÿ‡ณ๐Ÿ‡ต Curious about what gut microbes are doing inside us ๐Ÿค” Metabolomics- Lipidomics- Microbial metabolism-type 1 diabetes-autoimmunity

240 Followers  |  103 Following  |  9 Posts  |  Joined: 19.11.2024  |  2.2866

Latest posts by santoshlamichhane.bsky.social on Bluesky

There so much to learn what microbes are doing inside us. Glad to be part of this work, thanks to Pieter and the whole team.

13.06.2025 06:12 โ€” ๐Ÿ‘ 5    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Itโ€™s so nice that an important paper led by yasin - is out. www.nature.com/articles/s41.... This paper is a key milestone as it is the foundation for data science across data repositories through indexing and metadata harmonization of 1.6 million files (although much more now due to updates). 1/n

30.05.2025 14:16 โ€” ๐Ÿ‘ 20    ๐Ÿ” 7    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0

This paper represents a great effort by @roman-bushuiev.bsky.social and his brother @anton-bushuiev.bsky.social. The DreaMS foundation model for mass spectra of small molecules now opens lots of avenues for possible downstream applications. It might be a game changer for computational metabolomics.

24.05.2025 08:21 โ€” ๐Ÿ‘ 52    ๐Ÿ” 20    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1

Wow, that's so cool.. Happy belated holi, which is one of my fav festivals..

15.03.2025 07:07 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

San Diego is so much fun. If you have time, I would also suggest walking by La Jolla cove to the La Jolla Tide Pools area.

13.03.2025 06:30 โ€” ๐Ÿ‘ 3    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

I'm looking at a paper in a decent journal that claims to have separated glucose, mannose and fructose on a Waters C18 BEH column. There's no detailed methodology and there's no chromatograms. This seems just impossible. What do we do about this sort of thing? #Metabolomics

11.03.2025 05:29 โ€” ๐Ÿ‘ 2    ๐Ÿ” 2    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 1
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Free access to 2,656 metabolites from 9 platforms measured at 56 time points and covering 6 challenges "suffered" by 15 healthy volunteers:

The HuMet Repository - Watching human metabolism at work

www.sciencedirect.com/science/arti...

All data provided in an interactive repository:

humet.org

05.03.2025 12:52 โ€” ๐Ÿ‘ 33    ๐Ÿ” 11    ๐Ÿ’ฌ 4    ๐Ÿ“Œ 0

We thank all the co-authors - and many others that are not part of the paper - for the wonderful discussion on this topic. The discussion is an important education to the field and needs to be accurately presented - including existing computational solutions to handle.

03.03.2025 20:25 โ€” ๐Ÿ‘ 5    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Many discoveries will (probably have already) line up due to this crucial data driven strategy. Grateful to @pieterdorrestein.bsky.social and the entire team that i could contribute and be part of this very important data driven reverse #metabolomics workflow led by @vincentlamoureux.bsky.social

01.03.2025 05:28 โ€” ๐Ÿ‘ 4    ๐Ÿ” 4    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Discovery of metabolites prevails amid in-source fragmentation - Nature Metabolism Nature Metabolism - Discovery of metabolites prevails amid in-source fragmentation

I'm happy to share a correspondence in @naturemetabolism.bsky.social in which I was involved. #metabolomics #lipidomics www.nature.com/articles/s42...

28.02.2025 10:10 โ€” ๐Ÿ‘ 6    ๐Ÿ” 7    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Itโ€™s not every day one gets to publish an article with NASA astronauts. This journey started in 2019 and withe the goal to understand the microbial and chemical make-up of the space station. We had lots of experience with analysis from swabs on earth.

27.02.2025 18:52 โ€” ๐Ÿ‘ 42    ๐Ÿ” 17    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1

So, cool. I was lucky enough to witness some of these bile acid treasures in person, during my visit to UCSD (your lab) last year ๐Ÿ™๐Ÿพ.

27.02.2025 10:04 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Early in life, secondary bile acids are generated by colonizing microbes, associated with risks of immune-mediated diseases and act as immunomodulatory substances. Great collaborative study now online!

26.02.2025 02:27 โ€” ๐Ÿ‘ 21    ๐Ÿ” 7    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Trajectories of microbiome-derived bile acids in early life - Insights into the progression to islet autoimmunity Recent studies reveal that gut microbes produce diverse bile acid conjugates, termed microbially conjugated bile acids (MCBAs). However, their regulation and health effects remain unclear. Here, we an...

Happy to share this preprint from our team, great collaboration with Mikael Knip, @pieterdorrestein.bsky.social, @lahesmaalab.bsky.social, and @petterbrodin.bsky.social . Special kudos to @santoshlamichhane.bsky.social.
www.medrxiv.org/content/10.1...
#T1D #bileacids #autoimmunity #metabolomics

26.02.2025 02:24 โ€” ๐Ÿ‘ 16    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 3

This is such nice work, glad we could be part of it. Is shows how microbial bile acid amidates that differs in diabetic infants during their development could lead to immune dysbiosis.

26.02.2025 02:27 โ€” ๐Ÿ‘ 16    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Check out our new #preprint, a collaborative effort to explore emerging #bile acids (also referred as MCBAs) during early life. Briefly, here we analyzed MCBAs in early life and found distinct age-related trajectories linked to gut #microbiota, #immune modulation & islet #autoimmunity progression.

25.02.2025 19:09 โ€” ๐Ÿ‘ 5    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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got microbial metabolites? Add to the public knowledgebase available through GNPS2!

cmmc.gnps2.org

24.02.2025 18:28 โ€” ๐Ÿ‘ 17    ๐Ÿ” 13    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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๐Ÿšจ Abstract deadline alert! ๐Ÿšจ

Friendly reminder to submit your oral abstract before March 6 โ€“ donโ€™t miss the chance to showcase your work at hashtag#MetSoc2025!

Registration is now open: lnkd.in/eFZGi4CK

#Metabolomics #EMN

17.02.2025 10:33 โ€” ๐Ÿ‘ 13    ๐Ÿ” 13    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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We will be hosting the first @mzmine.bsky.social Community Meeting at @iocbprague.bsky.social. Please register if you wish to learn about the latest developments in mzmine. More info: docs.google.com/document/d/1...

17.02.2025 16:21 โ€” ๐Ÿ‘ 28    ๐Ÿ” 23    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Baat Gene Knockout Alters Post-Natal Development, the Gut Microbiome, and Reveals Unusual Bile Acids in Mice Bile acids (BAs) are steroid detergents in bile that contribute to fat absorption, cell signaling, and microbiome interactions. The final step in theiโ€ฆ

sciencedirect.com/science/article/pii/S0022227522001304?via%3Dihub

nature.com/articles/s41575-024-00914-3

science.org/doi/10.1126/science.adl4100

nature.com/articles/s41586-020-2047-9

14.02.2025 21:05 โ€” ๐Ÿ‘ 8    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Volume 135: Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS)

Important #PFAS news - Independent experts convened by the WHO's International Agency for Research on Cancer have classified #PFOA as carcinogenic to humans (Group 1) and #PFOS possibly carcinogenic to humans (Group 2B). In the past, manufacturers' mercenary scientists have questioned that evidence.

14.02.2025 18:50 โ€” ๐Ÿ‘ 54    ๐Ÿ” 18    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 3
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How does metabolomics help agriculture? Human health? A brief overview of this fungal metabolite-Fumonisin B2- shows the importance of this overlap. Check out more at cmmc.gnps2.org

Another impactful study of this metabolite: pubs.acs.org/doi/full/10.1021/jf0718906

07.02.2025 18:42 โ€” ๐Ÿ‘ 11    ๐Ÿ” 4    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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An atlas of metabolites driving chemotaxis in prokaryotes - Nature Communications In this meta-analysis, the authors compile results from 60 years of chemotaxis research into a database of prokaryotic chemoeffectors that compares and analyses their effects as attractant, repellent ...

Metabolites driving chemotaxis in prokaryotes www.nature.com/articles/s41...

07.02.2025 04:45 โ€” ๐Ÿ‘ 12    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
New features in mzmine 4.5
YouTube video by mzio GmbH New features in mzmine 4.5

New #mzmine release out now! Matching millions of reference spectra against thousands of samples was never faster. Go and test it today.

Download: github.com/mzmine/mzmin...

youtu.be/AFv55sUn9Lg

28.01.2025 13:11 โ€” ๐Ÿ‘ 35    ๐Ÿ” 13    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 2
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Meanwhile, this year winter here is mild and Finns keep cycling on the frozen roads ๐Ÿ˜‰

21.01.2025 05:31 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Our latest article "Data sharing restrictions are hampering precision health in the EU"
Here is the open acces link:
rdcu.be/d6Bgd
#precisionmedicine ๐Ÿงฌ๐Ÿ’Š๐Ÿงช

17.01.2025 12:59 โ€” ๐Ÿ‘ 13    ๐Ÿ” 4    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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Two-layer homolog network approach for PFAS nontarget screening and retrospective data mining - Nature Communications PFAS are a wide class of ubiquitous chemically persistent environmental pollutants. Here the authors combine nontarget screening with a two-layer network approach to identify large numbers of PFAS fro...

Here the authors used molecular networking to discover PFASs and reanalyze public data sets to show they are observed in data from seven countries. Such a nice reuse of public data - but also alarming as they are seen in data going back to 2005. www.nature.com/articles/s41...

17.01.2025 18:33 โ€” ๐Ÿ‘ 19    ๐Ÿ” 7    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Free fatty acid receptor 4 modulates dietary sugar preference via the gut microbiota - Nature Microbiology Bacteroides vulgatus, a gut bacterium, promotes GLP-1 secretion through its metabolite, pantothenate, inhibiting sugar preference in mice.

Could gut bacteria be the reason behind your sugar cravings? ๐Ÿคค

Check out this new paper by Zhang et al. linking a gut microbe, a free fatty acid receptor, and sugar intake.

www.nature.com/articles/s41...

14.01.2025 09:36 โ€” ๐Ÿ‘ 39    ๐Ÿ” 18    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 4
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Happy new year to all! We are back again with TWO featured metabolites. Check it out at cmmc.gnps2.org/molecule_month/

07.01.2025 20:06 โ€” ๐Ÿ‘ 7    ๐Ÿ” 4    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Interesting, observation. To my best understanding, in humans LCA might be cytotoxic and it affects immune function for that reason we excrete it.

21.12.2024 14:11 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

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