Post-Doctoral Fellow - Department of Cellular, Molecular, and Genetic Medicine - MCV Main Campus, Virginia, United States Advertising Summary: Virginia Commonwealth University (VCU) School of Medicine is a premier academic medical center located in the heart of Richmond. Accounting for almost half of VCU’s sponsored rese...

We have a post-doctoral fellow position in our laboratory. Please spread the news and encourage applications. Thank you!
vcujobs.com/jobs/post-do...

Love this Insight by @steeltownworms.bsky.social on a series of @elife.bsky.social papers on what it takes to reproduce a phenomenon of transgenerationally transmitted learned pathogen avoidance in C. elegans. Thank you, Lesley!
elifesciences.org/articles/109...

Canadian Parliament buildings

The CSMB is concerned that, despite new investments, Federal Budget 2025 weakens rather than strengthens Canada’s research ecosystem.
Sustainable research funding is essential for innovation and competitiveness.
Read more: csmb-scbm.ca/csmb-stateme...

#CSMB #Budget2025 #ResearchCanada #Science

Emerging functions for nonhistone protein acetylation in budding yeast Lysine acetylation is a post-translational modification (PTM) that is traditionally studied as a modifier of histones. In recent years, nonhistone protein acetylation has also emerged as a ubiquitous ...

New from Cameron Gibson and Idin Lantz of the Downey lab @oisb-ibso.bsky.social

www.cell.com/trends/bioch...

Six people stand and smile

Big news 🎉 Dr. @micheleardolino.bsky.social and team just received a $3M @terryfoxresearch.bsky.social grant to explore how the immune system, brain and gut work together to fight cancer: bit.ly/47XDOQi

New position available with our group related to a new research direction in cancer transcriptomics: www.biotalent.ca/the-petridis...
@oisb-ibso.bsky.social

Inhibition of nucleotide excision repair proteins associated with cancer chemotherapy DNA repair is involved in the cellular response to alkylating agents used for the treatment of various cancers, decreasing the damages induced by the …

The Gentile Lab at @oisb-ibso.bsky.social is on a roll:

www.sciencedirect.com/science/arti...

Impaired xCT-mediated cystine uptake drives serine and proline metabolic reprogramming and mitochondrial fission in skeletal muscle cells Muscle satellite cell (MuSC) proliferation is tightly regulated by redox homeostasis and nutrient availability, which are often disrupted in muscular …

New from Mary-Ellen Harper's lab at @oisb-ibso.bsky.social :

www.sciencedirect.com/science/arti...

Ca2+ Inhibits Reactive Oxygen Species Scavenging in Naked Mole-Rat Cortical Homogenates - Cellular and Molecular Neurobiology Deleterious perturbations in reactive oxygen species (ROS) and calcium (Ca2+) handling are key initiators of cell death in hypoxia-intolerant mammalian brain. Elevated cellular Ca2+ can also inhibit R...

New from Pamenter Lab @oisb-ibso.bsky.social :

link.springer.com/article/10.1...

New from Golshani Lab with first author Tom Kazmirchuk @oisb-ibso.bsky.social

ashpublications.org/bloodadvance...

Structure-based discovery of inhibitors of Mac1 domain of nonstructural protein-3 of SARS-CoV-2 by machine learning-augmented screening of chemical space Significant efforts have been recently dedicated to the discovery of small molecule inhibitors against the Macrodomain 1 (Mac1) of nonstructural protein 3 (NSP3) as potential antivirals for SARS-CoV-2...

New work from Francesco Gentile lab at @oisb-ibso.bsky.social:

www.biorxiv.org/content/10.1...

Identification of organelle-specific autophagy regulators from tandem CRISPR screens Losier et al. identify distinct kinase signaling pathways that differentially regulate bulk and selective autophagy. Using kinome-wide CRISPR screening, th

Exciting new work from the Russell Lab @oisb-ibso.bsky.social
rupress.org/jcb/article/...

The colonic mucosal virome in inflammatory bowel disease reveals Crassvirales depletion and disease-specific virome features The mucosal virome is increasingly recognized for its potential role in shaping intestinal health and disease. Building on previous findings, we analyzed the mucosal virome from 51 individuals, inc...

New from Stintzi Lab at OISB:
www.tandfonline.com/doi/full/10....

Next we'll hear from Cian Ward from Pat O'Donaghue's lab at Western University about tRNA anticodon variants to read through ALS-causative PTCs. 🛑🏁 @trendrna.bsky.social #TREnD2025

Excited to hear from patients, advocates, and clinicians about RNA-related diseases at our @rnacanada.bsky.social patient advocacy panel. These conversations are so important to connect researchers, families, and clinicians. Thanks for sharing your stories! @trendrna.bsky.social #TREnD2025

Genome Sciences is looking for a Director of Departmental Computing. This is a rare opportunity for someone interested in leading our excellent IT team, building and maintaining computational infrastructure, and working closely with our faculty and labs uwhires.admin.washington.edu/ENG/candidat...

Yeast centrosomes act as organizing centers to promote Polo kinase–mediated adaptation to persistent DNA damage | PNAS The ability of cells to overcome cell cycle arrest and adapt to the presence of unrepairable DNA damage is under the control of Polo-like kinases (...

New from D'Amours Lab at @oisb-ibso.bsky.social
www.pnas.org/doi/10.1073/...

New work on polyphosphate biology from the Downey lab @oisb-ibso.bsky.social:

journals.asm.org/doi/10.1128/...

The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy Mis-splicing of autophagy genes contributes to diverse pathologies including cancer. Mathavarajah et al. report that depletion of tumor suppressor and splicing kinase PRP4K leads to impaired autophagy...

🔥12 years in the making!🔥
So excited our paper is finally out in Cell Reports!
Great collaboration with Dr. Robert Huber @ Trent U, funded by NSERC and CIHR.

The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy: www.cell.com/cell-reports...

Microbes and bikes: perfect mix to get me to Montréal! #yul

Social card with bluebird promoting CSEE webinar: Performing Peer Review: Part One.

‪@csee-scee.bsky.social members—join us for a practical webinar on peer review, hosted by the @cdnsciencepub.com team. Learn how to write strong reviews and get involved as a future reviewer.

Check your inbox to register. 📥

#AcademicSky #SciComm 🧪 #AcWri #PHDSky #ScholComms #OpenScience #SciPol

Figure 1. (A) During male meiosis, mealybugs undergo paternal genome elimination (PGE), where paternally inherited chromosomes become heterochromatinized and are excluded into degenerating nuclei, while maternally inherited chromosomes are retained in functional sperm. (B) During female meiosis, the B chromosome follows standard Mendelian inheritance. In males, when maternally inherited, it behaves like other maternal chromosomes and is transmitted through functional sperm. Strikingly, when paternally inherited, the B chromosome escapes elimination by decondensing during meiosis, adopting a euchromatic state similar to that of maternal chromosomes, and co-segregates with them into the functional sperm nucleus.

"Selfish B chromosome evades genome elimination"
by Cécile Courret (@cecilecourret.bsky.social)

This Spotlight highlights recent work by Laura Ross (@laurarossevo.bsky.social) & colleagues in GBE (@genomebiolevol.bsky.social).

FREE till Aug 5th with this link:
authors.elsevier.com/a/1lH50cQbJF...

Director of The Neuro (Montreal Neurological Institute-Hospital) - A joint position Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

Who wants to be my new chair?

mcgill.wd3.myworkdayjobs.com/en-US/McGill...

🤔 Are you unsure what jobs you can get with your molecular biosciences degree, other than research? Then join the @csmb-scbm.bsky.social next Thursday, June 19, for our next webinar where we'll hear from three scientists with jobs in scientific writing!

Sign up here: zoom.us/meeting/regi...

New work from @oisb-ibso.bsky.social member Francesco Gentile: www.tandfonline.com/doi/10.1080/...

Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma - PubMed The von Hippel-Lindau (VHL) tumor suppressor is a substrate-defining component of E3 ubiquitin ligase complexes that target cellular substrates for proteasome-mediated degradation. VHL inactivation by...

new from Ryan Russell's Group @oisb-ibso.bsky.social

pubmed.ncbi.nlm.nih.gov/40240354/

New from SH Lee at @oisb-ibso.bsky.social

immunenetwork.org/DOIx.php?id=...

A stress-dependent TDP-43 SUMOylation program preserves neuronal function - Molecular Neurodegeneration Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are overwhelmingly linked to TDP-43 dysfunction. Mutations in TDP-43 are rare, indicating that the progressive accumulation of exo...

New from Rousseaux lab @oisb-ibso.bsky.social:
molecularneurodegeneration.biomedcentral.com/articles/10....