Bianca Schrul

ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth - Nature Structural & Molecular Biology Elhan et al. show that ATG2A acts with DGAT2, the enzyme producing triacylglycerol (TAG), in lipid droplet growth. By delivering diacylglycerol to lipid droplets, ATG2A not only fuels TAG production b...

Thrilled to share our latest work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and some TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes.
www.nature.com/articles/s41...

Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO

Congratulations!!

An enzymatic cascade enables sensitive and specific proximity labeling proteomics in challenging biological systems - Nature Communications Proximity labeling allows proteomic mapping of subcellular structures. Here, Sroka et al. develop in situ APEX activation (iAPEX) to overcome limitations of labeling specificity and H2O2 toxicity, app...

Thrilled to share "in situ APEX activation" (iAPEX), a proximity labeling technology for subcellular #proteomics applied to primary #cilia. iAPEX uses an enzymatic cascade, in which a D-amino acid oxidase locally produces H2O2 to activate ascorbate peroxidase.
www.nature.com/articles/s41...

Curious how proteins find their way to #LipidDroplets?

Our bipartite review traces their journey from ER insertion to LD partitioning:

👉 Navigating lipid droplet proteins - part II: Molecular mechanisms of ER-to-LD protein partitioning

#Organelles
#EndoplasmicReticulum
#ER_Literature

Curious how proteins find their way to #LipidDroplets?

Our bipartite review traces their journey from ER insertion to LD partitioning:

👉 Navigating lipid droplet proteins - part I: ER targeting routes of LD-destined membrane proteins

#EndoplasmicReticulum
#ER_Literature
#Organelles
#Biochemistry

T cell cholesterol transport links intestinal immune responses to dietary lipid absorption The intrinsic pathways that control membrane organization in immune cells and their impact on cellular functions are poorly defined. We found that the nonvesicular cholesterol transporter Aster-A link...

amazing #lipidtime story from Tontonoz lab! Lipid scrambling and cholesterol accessibility IN T-CELLS regulates nutrient uptake in small intestine 🤯🤯

Physiology is so weird!
www.science.org/doi/10.1126/...

First pizza lunch after a whirlwind week moving into our brand-new research building. Exhausted, but absolutely thrilled by the incredible facilities & lab space. Can’t wait to dive back into science.
A few benches are still waiting for curious minds: PhD students and postdocs, come join us! 😉

Congratulations!!!

Wow! Congratulations!

Upcoming interdisciplinary meeting: Cell Physics 2025
When? October 7-9, 2025
Where? Saarbruecken, Germany
Relevant dates? Early-bird deadline: June 30, regular registration by August 31
Several opportunities for short-talks selected from abstracts
More info at: cell-physics.uni-saarland.de

The abstract submission deadline for the 2nd edition of our #EMBOLipidDroplets Workshop (21-26 September 2025) is approaching.

Check out the agenda with an amazing lineup of speakers and submit your abstract before 10 June 2025!

@embo.org
@biologists.bsky.social

meetings.embo.org/event/25-lip...

W2 Professorship (with tenure track to W3) in the Dynamics of Biological Systems (m/f/x) - Universität des Saarlandes Universität des Saarlandes bietet Stelle als W2 Professorship (with tenure track to W3) in the Dynamics of Biological Systems (m/f/x) in Saarbrücken - jetzt bewerben!

We are looking for a new colleague in the biology department at Saarland University!

We are looking for excellent Cell Biologists / Cell Physiologists for a W2 tenure track W3 professorship in 'Dynamics of Biological Systems'.

Please share!

jobs.zeit.de/jobs/w2-prof...

Dear #LipidDroplet friends, we are so much looking forward to the 2nd edition of our #EMBOLipidDroplets Workshop. Join us 21-26 September 2025 at beautiful Costa Brava!

Abstract submission deadline is 10 June 2025.

@embo.org
@biologists.bsky.social

meetings.embo.org/event/25-lip...

Congratulations!!

Time for lipid cell biology Nature Cell Biology - It is an exciting time for lipid metabolism and membrane cell biologists as technological progress has increased our ability to study lipids in cells. We asked leaders...

Hello Bluesky research community.
I announce that it's time for lipid cell biology!
rdcu.be/d8HKL

Congratulations! Well deserved!

This cannot be reiterated enough.

Congratulations! This is awesome!

iAPEX: Improved APEX-based proximity labeling for subcellular proteomics using an enzymatic reaction cascade Ascorbate peroxidase (APEX) is a versatile labeling enzyme used for live-cell proteomics at high spatial and temporal resolution. However, toxicity of its substrate hydrogen peroxide and background la...

Proud to share our work spear-headed by PhD student Tommy Sroka with major contributions by #xenopus expert Kerstin Feistel.

Our iAPEX #ProximityLabeling method for #MassSpec based subcellular #proteomics works by locally generating H2O2 using a D-amino acid oxidase that activates APEX2 in situ.

Congratulations!!

Interested in #organelle biogenesis, subcellular #protein targeting, physicochemical #membrane properties or #LipidMetabolism?

👉 We are hiring! #PhDstudent #postdoc

Interdisciplinary projects combining #Biochemistry & #CellBiology with Computational Modeling & Physical Chemistry available.

1. I feel like this is such obvious advice that it gets taken for granted & consequently no one says this to young scientists but READ PAPERS, read all the papers. As you move up in your career you will have less & less time to do this. Read everything that appeals to you not just in your field

Wow! Congratulations, James!

New grant approved! Hooray! Looking for a #PhDstudent with strong interest in membrane protein reconstitution, physicochemical membrane properties and FRET-based assays. 👉 Which membrane properties drive protein partitioning to #LipidDroplets?

Please share!

#organelles #PhDposition #ScienceJobs

Lipid Droplets: Cell-Biological Control of Metabolism Lipid droplets are master regulators of nutrient and energy homeostasis, but their functions go far beyond these classical roles: They are important in cellular differentiation and various stress res…

Dear #LipidDroplet friends, we just launched the website for the next #EMBOLipidDroplets Workshop in September 2025, again at beautiful Costa Brava. Check out the amazing lineup of speakers. Abstract submission deadline is 10 June 2025. Hope to see many of you there! #organelles #LipidMetabolism

Congratulations! That is amazing!

Ein Jahr kostenfreie Mitgliedschaft bei der GBM bei Registrierung bis Ende März 2025! Become a member of the GBM now and the 1st year is for free!

Reach out to us, if you like to work in an interdisciplinary setting and would like to join our young and growing team 👇

Interested in #organelle biogenesis, subcellular #membrane #protein targeting or #LipidMetabolism? We are hiring! #PhD student or #postdoc.
We combine #Biochemistry & #CellBiology with Computational Modeling & Experimental Physics / Physical Chemistry approaches.
#research #academicsky #AcademicJob