MHR | Foundations of Reproductive Science

Congrats to the authors and all those involved!!
@Amilia Zisiadi @Ellen Anckaert

A matrix-free 3D in vitro follicle culture system in mice exhibits enhanced oocyte meiotic and developmental competence compared to hydrogel encapsulation Abstract. In vitro follicle culture (IFC) is an emerging fertility preservation alternative for women and children with cancer. Because two-dimensional (2D

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✨A comparative study of different 3D mouse in vitro #follicleculture methods reveals that the matrix-free non-attachment system is more efficient than complex encapsulation methodologies, sustaining high oocyte meiotic and developmental competence.

#EditorChoice
Free to read 🔗📚

In vitro follicle culture is an emerging #FertilityPreservation solution for women and children with cancer. Recent advances have yielded various 3D methods that preserve follicular structure.
Which is the best?🧐

Early signaling pathways during in vitro culture of isolated primordial follicles Abstract. The ability to grow undifferentiated oocytes in vitro from primordial follicles would increase the availability of fully grown oocytes in fertili

“Early signaling pathways during in vitro culture of isolated primordial follicles”

Don’t miss this interesting piece investigating the main transcriptional events and molecular factors determining follicle fate 🧫🐮

Dive into the full article 🔗👇
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🚨 𝐒𝐚𝐯𝐞 𝐭𝐡𝐞 𝐝𝐚𝐭𝐞! | Alberto de la Iglesia 🚨 𝐒𝐚𝐯𝐞 𝐭𝐡𝐞 𝐝𝐚𝐭𝐞! 🚨 Join us on 𝐎𝐜𝐭𝐨𝐛𝐞𝐫 𝟏𝟔𝐭𝐡, 𝟐𝟎𝟐𝟓 🗓️ for the upcoming #POHaD symposium that Julie Cocquet and I are organizing together with GDR Reproduction. This meeting, focused on the 𝐏𝐚𝐭𝐞𝐫𝐧𝐚𝐥 𝐎𝐫...

www.linkedin.com/posts/albert...

Registration form - POHaD GdR Symposium By filling this form, you will confirm your registration to the upcoming POHaD hybrid Symposium taking place next October 16th, 2025. Registration is free of cost but mandatory. Abstract submission is...

The #POHaD symposium will gather international scientists interested in how male germ cells are sensitive to external exposures and the impacts beyond fertilization.
Don’t miss this great opportunity!

🚨Save the date for the Symposium on the Paternal Origins of Health and Disease!

🗓️October 16th, 2025
📍Institut Cochin (Paris, France) and online
🔗 Registration👇👇

WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Organoids): endometrial organoids as an emerging technology for endometrios... Abstract. The aetiology of endometriosis remains poorly understood. In vitro model systems provide the opportunity to identify the mechanisms driving disea

Marr et al. discusses the use of #organoids as an emerging technology to study endometriosis, and the possibility to develop more complex organoid systems (assembloids) that reflect the interplay of multiple cell types in vivo.
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WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Pain): methods to assess pain behaviour in rodent models of endometriosis Abstract. Pain is a debilitating symptom of endometriosis, and its mechanisms are often explored using rodent models. However, a lack of harmonization amon

Dodds et al. examines the methods to assess #pain-associated behaviors in rodent models of endometriosis, and offers best practice recommendations for conducting such tests, aiming to improve study comparability.
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WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Heterologous): heterologous rodent models Abstract. Endometriosis, defined as the growth of endometrial-like tissues outside the uterus, is a common disease among women. Numerous in vivo rodent mod

Hull et al. focuses on #heterologous rodent models. In this case, what can be standardized includes tissue placement, hormonal status, and the housing conditions for mice with compromised immune systems.
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WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Homologous): homologous rodent models Abstract. In vivo models of endometriosis enable the discovery and preclinical testing of new therapies. Several rodent models of endometriosis exist, but

Burns et al. discusses the use of #homologous rodent models, which mainly consist of the intraperitoneal transplantation of uterine tissue, and the importance to define standardizing parameters, such as method of induction, and ectopic tissue placement.
academic.oup.com/molehr/artic...

Enhancing collaboration in endometriosis research through the initiative of the World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project (EPHect) Endometriosis affects an estimated >200 million women (and those assigned female at birth) during their most active and reproductive years, causing a hi

This remarkable initiative brings together 44 collaborators from 11 countries, resulting in the publication of 1 #editorial and 4 #articles in the latest issue of Molecular Human Reproduction!

@endometriosis #womenshealth
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✨Exciting news!✨
The World Endometriosis Research Foundation (#WERF) – Endometriosis Phenome and Biobanking Harmonisation Project (#EPHect) today publishes #SOPs to optimize the use of experimental in vivo and in vitro models in #endometriosis research.

🤩 See you soon at the #MHRsymposium!!

📍 Session 53, Tuesday from 14:00-15:15

Oxford University Press
@eshre.bsky.social

🤩ESHRE journals’ “Parisian cafe'” at #ESHRE2025!!

Oxford University Press European Society of Human Reproduction and Embryology (ESHRE) @eshre.bsky.social

#MHR #ESHREjournals #EarlyCareerInnovatorSeries

Excited for #ESHRE2025 in Paris!!🤩
Join us at the Precongress Course 12:
“Academic authorship - Milestones in reproductive science: highlights from ESHRE Journals”

Eutopic macrophages facilitate endometriosis progression via ferroptosis-mediated release of S100A9 Abstract. Endometriosis is a chronic inflammatory disorder in which immune cells, specifically macrophages, play a pivotal yet incompletely understood role

📣Now online!
“Eutopic #macrophages facilitate #endometriosis progression via ferroptosis-mediated release of S100A9”
academic.oup.com/molehr/advan...

✨Congrats to all the authors, including
Matthew L. Anderson, Burak Un, Umit Kayisli, Begum Mathyk, Jake Rymer

Overexpression of high affinity Type I adenosine receptors promotes the growth of uterine leiomyomas Abstract. Leiomyomas are benign proliferations of uterine smooth muscle found in 60% of women. A spatial redistribution of ecto-5’-nucleotidase (CD73, NT5E

In this article, the authors explored the mechanisms by which altered extracellular adenosine levels contribute to fibroids growth, and identified the #overexpression of ADORA1 receptor in leiomyoma.
academic.oup.com/molehr/advan...

In leiomyomas., it has been found a spatial redistribution of ecto-5’-nucleotidase that results in reduced extracellular concentrations of adenosine.

Uterine #leiomyomas, also known as #fibroids, are benign tumors found in about 60% of pre-menopausal women, and can cause abnormal uterine bleeding, pelvic pain and #infertility.

Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Hospital Clínic de Barcelona, IRB Barcelona, Barcelona Institute of Science and Technology (BIST)

Congrats to the authors and all those involved!
Judit Castillo, Marina Gay, Alberto de la Iglesia, Gianluca Arauz Garofalo, Mar Vilanova Tuñón, Marina leiva, Juan Manuel Corral Molina, Dolors Manau MD, PhD, Marta Vilaseca, Meritxell Jodar Bifet, Rafael Oliva

Alterations in the abundance of protamine proteoforms related to sperm chromatin packaging, obesity, and age in normozoospermic men Abstract. Protamines are considered among the most relevant sperm proteins because of their functional implications on paternal genome packaging and protec

Their findings suggest that protamine proteoforms in the male gamete act as additional layers of #epigeneticinformation, the alteration of which might be related to some cases of impaired #spermfunction. 🔗📚
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📣New paper alert on #human sperm protamine proteoforms!

Using a refined top-down mass spectrometry protocol, the authors observed significant differences in specific #ProtamineProteoforms related to sperm #chromatin packaging #alterations, #obesity and #aging.

✨The #ESHRE Annual Meeting 2025 is just around the corner!

Join us at the #MHRsymposium where MHR’s Editor-in-Chief, @Boiani Michele, and Deputy Editor, @Francesca Duncan, will be hosting the session about Basic principles of ovarian function in vivo and in vitro.

Mechanical signal-mediated mitochondria–endoplasmic reticulum contacts modulate Leydig cell testosterone biosynthesis during testis development Abstract. In males, 95% of testosterone is synthesized by Leydig cells, and a deficiency in this synthesis will cause metabolic disorders and multiple orga

“#Mechanical signal-mediated mitochondria–endoplasmic reticulum contacts modulate Leydig cell testosterone biosynthesis during #testisdevelopment”

Free to read 🔗📚 academic.oup.com/molehr/artic...

Mosaicism is more than meets the eye: transcriptional consequences of blastocyst mosaicism Abstract. Blastocyst mosaicism is increasingly detected due to advances in preimplantation genetic testing for aneuploidy (PGT-A). While some mosaic embryo

Dive into the research 🔗👇
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#Mosaicism is generally defined as heterogeneity of DNA content among the #embryonic cells.

Using a novel method enabling simultaneous sequencing of both gDNA and mRNA, this study elucidates the transcriptomic profile of #MosaicEmbryos.