Olov Andersson

Volumetric near-infrared light-sheet imaging of a calcium indicator (WHaloCaMP) in a zebrafish larval brain. Credit to @helenfarrants.bsky.social, William "Bill" Lemon, & Philipp Keller at @hhmijanelia.bsky.social. #ZebrafishZunday 🧪

Bri2 BRICHOS domain inhibits IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress - Diabetologia Aims/hypothesis Accumulation of islet amyloid polypeptide (IAPP) and amyloid formation is associated with beta cell dysfunction and cell death in human islets and may also contribute to graft failure ...

Bri2 BRICHOS domain inhibits cytotoxic IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress. #T1D #SC-islets #CellTherapy
link.springer.com/article/10.1... 🔓

Islet Biology and Diabetes: Beta Cell Compensation, Failure and Recovery | Keystone Symposia Join us at the Keystone Symposia on Islet Biology and Diabetes: Beta Cell Compensation, Failure and Recovery, March 2026, in Breckenridge, with field leaders!

Deadlines are approaching (some next week!) for @keystoneSymposia.bsky.social #IsletBiology & #Diabetes : #BetaCell Compensation, Failure & Recovery, this March in Breckenridge! See scholarship, abstract and discount reg dates: keysym.us/KSDiabetes26 #KSDiabetes26

YouTube video by KeystoneSymposia KSQA: Dr. Amelia K. Linnemann (Islet Biology and Diabetes)

Nov 18 is the deadline for short talk abstracts + scholarship apps for the Keystone Symposium on Islet Biology & Diabetes. Hear more from @linnemannlab.bsky.social: 🎥 youtu.be/4olDczSNJMo.

Apply: keysym.us/KSDiabetes26

#KSDiabetes26 #diabetes #drugdiscovery @o-andersson-lab.bsky.social

The deadline for short talks at the Keystone Islet Biology symposium is approaching (Nov 18th) - submit it here: www.keystonesymposia.org/conferences/...

For great science and skiing March 16-19th in Breckenridge, Colorado @linnemannlab.bsky.social @keystonesymposia.bsky.social

Benchmarking porcine pancreatic ductal organoids for drug screening applications | EMBO Molecular Medicine imageimageState-of-the-art single-cell RNA sequencing and proteomics approaches were employed to benchmark porcine and human pancreatic ductal organoid systems for use as a drug screening and testing ...

Happy to share that our preprint is now published at @embomolmed.org! We expanded on the benchmark of porcine ductal organoids by a pretty extensive proteomics dataset to compare organoids derived from different developmental stages of the pig #devbio #PancSky www.embopress.org/doi/full/10....

nice & very interesting. How does it relate to the ER stress in mild MODY10 variants that doesn't affect cysteines and db/db mice that have misfolded proinsulin? Are these special cases or misfolded proinsulin precipitate a cascade that spread?

@zebrafishrock.bsky.social @uu.se

Postdoctoral Fellowships at Uppsala University - 2026 - Novo Nordisk Fonden

Any danish located postdoc who wants to apply to work with us and zebrafish, pls contact me (postdocs from other places can also get in touch, as we have other alternatives)
novonordiskfonden.dk/en/grant/pos...

Join us for the revival of the Islet Biology and Diabetes Keystone symposia in Breckenridge, Colorado on March 16-19, 2026, for great science and great skiing. You can register now for early bird rates: lnkd.in/dw59T7tc Joint with Gut-Brain Axis. @linnemannlab.bsky.social Erica Nishimura, Barak Blum

LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes - Nature Metabolism LONP1, whose expression is downregulated in islets from donors with type 2 diabetes, is vital to mediate efficient mitochondrial protein folding, thus preventing proteotoxicity and promoting islet β c...

Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔

🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n

Professor of Pharmacology - Uppsala University Professor of Pharmacology, Department of Medical Cell Biology, Uppsala University

Join us as a professor by taking this great opportunity in pharmacology (in any system/area) www.uu.se/en/about-uu/...

Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish - Nature Communications During partial liver injury in growing zebrafish, cholangiocytes regenerate hepatocytes through transdifferentiation, revealing a stage-specific regeneration mechanism regulated by mTORC1 signaling.

🚨 Just out in Nature Communications:
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)

Our paper has been out for a while but was included in today's issue, featuring our cover suggestion made by the brilliant Mattias Karlen
www.nature.com/nchembio/vol...
@ckarampelias.bsky.social @uu.se

Assistant Professor in Environmental Physiology Uppsala University’s tenure track system grants assistant professors the possibility to be assessed for promotion to the position as associate professor. The university provides support in various a

Here is a similar assistant professorship with great startup, but deadline in a few days uu.varbi.com/en/what:job/...

Assistant Professor in Environmental Physiology Uppsala University’s tenure track system grants assistant professors the possibility to be assessed for promotion to the position as associate professor. The university provides support in various a

Bring your favourite model system and help advance our understanding of how living organisms interact with and adapt to their environment.
Apply here: uu.varbi.com/en/what:job/...

A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as major modulators of mucosal healing The intestine is a semipermeable tissue responsible for the absorption of essential nutrients while limiting exposure to harmful environmental factors. To maintain these functions, the intestinal epit...

We’re excited to share our recently published story

“A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing”

in @mucosalimmunol.bsky.social

Fantastic work led by @ramoralescastro.bsky.social !

www.mucosalimmunology.org/article/S193...

Interphase cell morphology defines the mode, symmetry, and outcome of mitosis During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...

What an elegant study showing that the mode and shape of cell division is defined by interphase morphology! This work suggests how cell fate and morphological asymmetries can be propagated via cell division in tissues.

www.science.org/doi/10.1126/...

#academiasky

At the Stainier lab’s 30th year celebration, funtastic colleagues

We have made a p5E with fabp10a and I can share with you

yes, we want more zebrafish scientists too, this time as “assistant professor”

Associate Senior Lecturer (SciLifeLab Fellow) in inflammation research The Science for Life Laboratory (SciLifeLab) is a national center for leading edge technological infrastructures that supports large-scale data and hypothesis-driven research in the field of molecular

Great opportunity & startup for someone that wants to start their lab studying inflammation/immune system (perhaps in metabolism, diabetes or the islet...) external/international candidates are wanted:
uu.varbi.com/en/what:job/...

Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay Insulin gene variation predisposes individuals to type 1 diabetes (T1D). We report a new mechanism of genetic protection from T1D in which insulin mRNA with a protective SNP is broken down by IRE1α, t...

Amazing work on a DRiP neoantigen in beta-cells, where a protective SNP creating an IRE1 digestion motif and reducing the level of ER stress, DRiP, and type 1 diabetes...
www.cell.com/cell/fulltex...

Deadline extended to March 23!!👇

Benchmarking porcine pancreatic ductal organoids for drug screening applications Primary human pancreatic ductal organoids (HPDO) have emerged as a model to study pancreas biology and disease. Yet, donor material availability, and a lack of extensive benchmarking limits the range ...

Happy to share our work on pancreatic ductal organoids from the human-relevant pig model across developmental stages ranging from embryonic to adult animals and using them for drug screening applications from the @heikolickert.bsky.social lab. #PancSky #devbio 🧪🧬 www.biorxiv.org/content/10.1... /1

Thank you Bart Roep for visiting, explaining a "not unlikely" beta-cell-centric origin of type 1 diabetes, and giving us a sneak peak of next week's issue of Cell

Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin Mesenchymal cells and the extracellular matrix (ECM) support epithelium during homeostasis and regeneration. However, the role of the mesenchyme in ep…

1/6 Proudly presenting Sharif’s @sharifiqbal.bsky.social paper on the role of Asporin in intestinal regeneration through TGF-B-dependent fetal-like reversion www.sciencedirect.com/science/arti... out in @cp-cellstemcell.bsky.social @pekka-katajisto.bsky.social @helsinki.fi @metastem.bsky.social 🧵

Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates Single-cell profiling of the amphioxus digestive tract reveals scattered distribution of three endocrine-like cell clusters.

A new #evolution #EvoDevo #devbio #amphioxus #invertebrate paper this week @ScienceAdvances | Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates
www.science.org/doi/full/10....

Notable inclusions include latests works of the Martik Lab, @sgraingerphd.bsky.social, @singhlab.bsky.social, @ditalialab.bsky.social, @o-andersson-lab.bsky.social, @blmartin.bsky.social, @tillymommersteeg.bsky.social, Megason Lab, Yelon Lab, Maves Lab, @thelovelylab.bsky.social among others!

Mechanistic insights and approaches for beta cell regeneration - Nature Chemical Biology This Review highlights recent advances in the identification of small-molecule mediators of beta cell regeneration, discussing the diverse pathways and cellular processes altered by these compounds.

Check out our review on beta-cell regeneration - special thanks to the great coauthors @ckarampelias.bsky.social et al #UppsalaUniversity #HelmholtzMunich www.nature.com/articles/s41...