Olov Andersson

LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes - Nature Metabolism LONP1, whose expression is downregulated in islets from donors with type 2 diabetes, is vital to mediate efficient mitochondrial protein folding, thus preventing proteotoxicity and promoting islet β c...

Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔

🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n

Professor of Pharmacology - Uppsala University Professor of Pharmacology, Department of Medical Cell Biology, Uppsala University

Join us as a professor by taking this great opportunity in pharmacology (in any system/area) www.uu.se/en/about-uu/...

Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish - Nature Communications During partial liver injury in growing zebrafish, cholangiocytes regenerate hepatocytes through transdifferentiation, revealing a stage-specific regeneration mechanism regulated by mTORC1 signaling.

🚨 Just out in Nature Communications:
Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish
We challenge old assumptions on liver regeneration!
🔗 nature.com/articles/s41...
🧵(1/8)

Our paper has been out for a while but was included in today's issue, featuring our cover suggestion made by the brilliant Mattias Karlen
www.nature.com/nchembio/vol...
@ckarampelias.bsky.social @uu.se

Assistant Professor in Environmental Physiology Uppsala University’s tenure track system grants assistant professors the possibility to be assessed for promotion to the position as associate professor. The university provides support in various a

Here is a similar assistant professorship with great startup, but deadline in a few days uu.varbi.com/en/what:job/...

Assistant Professor in Environmental Physiology Uppsala University’s tenure track system grants assistant professors the possibility to be assessed for promotion to the position as associate professor. The university provides support in various a

Bring your favourite model system and help advance our understanding of how living organisms interact with and adapt to their environment.
Apply here: uu.varbi.com/en/what:job/...

A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as major modulators of mucosal healing The intestine is a semipermeable tissue responsible for the absorption of essential nutrients while limiting exposure to harmful environmental factors. To maintain these functions, the intestinal epit...

We’re excited to share our recently published story

“A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing”

in @mucosalimmunol.bsky.social

Fantastic work led by @ramoralescastro.bsky.social !

www.mucosalimmunology.org/article/S193...

Interphase cell morphology defines the mode, symmetry, and outcome of mitosis During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...

What an elegant study showing that the mode and shape of cell division is defined by interphase morphology! This work suggests how cell fate and morphological asymmetries can be propagated via cell division in tissues.

www.science.org/doi/10.1126/...

#academiasky

At the Stainier lab’s 30th year celebration, funtastic colleagues

We have made a p5E with fabp10a and I can share with you

yes, we want more zebrafish scientists too, this time as “assistant professor”

Associate Senior Lecturer (SciLifeLab Fellow) in inflammation research The Science for Life Laboratory (SciLifeLab) is a national center for leading edge technological infrastructures that supports large-scale data and hypothesis-driven research in the field of molecular

Great opportunity & startup for someone that wants to start their lab studying inflammation/immune system (perhaps in metabolism, diabetes or the islet...) external/international candidates are wanted:
uu.varbi.com/en/what:job/...

Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay Insulin gene variation predisposes individuals to type 1 diabetes (T1D). We report a new mechanism of genetic protection from T1D in which insulin mRNA with a protective SNP is broken down by IRE1α, t...

Amazing work on a DRiP neoantigen in beta-cells, where a protective SNP creating an IRE1 digestion motif and reducing the level of ER stress, DRiP, and type 1 diabetes...
www.cell.com/cell/fulltex...

Deadline extended to March 23!!👇

Benchmarking porcine pancreatic ductal organoids for drug screening applications Primary human pancreatic ductal organoids (HPDO) have emerged as a model to study pancreas biology and disease. Yet, donor material availability, and a lack of extensive benchmarking limits the range ...

Happy to share our work on pancreatic ductal organoids from the human-relevant pig model across developmental stages ranging from embryonic to adult animals and using them for drug screening applications from the @heikolickert.bsky.social lab. #PancSky #devbio 🧪🧬 www.biorxiv.org/content/10.1... /1

Thank you Bart Roep for visiting, explaining a "not unlikely" beta-cell-centric origin of type 1 diabetes, and giving us a sneak peak of next week's issue of Cell

Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin Mesenchymal cells and the extracellular matrix (ECM) support epithelium during homeostasis and regeneration. However, the role of the mesenchyme in ep…

1/6 Proudly presenting Sharif’s @sharifiqbal.bsky.social paper on the role of Asporin in intestinal regeneration through TGF-B-dependent fetal-like reversion www.sciencedirect.com/science/arti... out in @cp-cellstemcell.bsky.social @pekka-katajisto.bsky.social @helsinki.fi @metastem.bsky.social 🧵

Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates Single-cell profiling of the amphioxus digestive tract reveals scattered distribution of three endocrine-like cell clusters.

A new #evolution #EvoDevo #devbio #amphioxus #invertebrate paper this week @ScienceAdvances | Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates
www.science.org/doi/full/10....

Notable inclusions include latests works of the Martik Lab, @sgraingerphd.bsky.social, @singhlab.bsky.social, @ditalialab.bsky.social, @o-andersson-lab.bsky.social, @blmartin.bsky.social, @tillymommersteeg.bsky.social, Megason Lab, Yelon Lab, Maves Lab, @thelovelylab.bsky.social among others!

Mechanistic insights and approaches for beta cell regeneration - Nature Chemical Biology This Review highlights recent advances in the identification of small-molecule mediators of beta cell regeneration, discussing the diverse pathways and cellular processes altered by these compounds.

Check out our review on beta-cell regeneration - special thanks to the great coauthors @ckarampelias.bsky.social et al #UppsalaUniversity #HelmholtzMunich www.nature.com/articles/s41...

PhD student in regeneration of insulin-producing beta-cells in diabetes models - Uppsala University PhD student in regeneration of insulin-producing beta-cells in diabetes models, Institutionen för medicinsk cellbiologi, Uppsala University

Fancy joining our lab? apply here for a PhD student position, (DM me for potential postdoc opportunities)
www.uu.se/en/about-uu/...

Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish The liver's regenerative ability depends on injury extent. Minor injuries are repaired by hepatocyte self-duplication, while severe damage triggers cholangiocyte involvement in hepatocyte recovery. Th...

Excited to share our latest work on #liver #regeneration in @biorxiv-devbio.bsky.social ! We uncover how cholangiocytes contribute to hepatocyte regeneration, even in the presence of spared hepatocytes, using our novel CellCousin model in #zebrafish: www.biorxiv.org/content/10.1... 🐟✨ A 🧵👇 (1/12)

Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish The liver's regenerative ability depends on injury extent. Minor injuries are repaired by hepatocyte self-duplication, while severe damage triggers cholangiocyte involvement in hepatocyte recovery. Th...

and don't miss this other preprint by our great collaborators @singhlab.bsky.social:
www.biorxiv.org/content/10.1...

Big thank you to Jiarui Mi, for making this possible by generating several novel knock-in lines enabling the lineage-tracing, and all the other coauthors @uumediacomms.bsky.social @karolinskainst.bsky.social

Check out our preprint about liver regeneration, showing hepatic duct heterogeneity and cell plasticity using lineage tracing and single-cell transcriptomics. @zebrafishrock.bsky.social @biorxivpreprint.bsky.social @the-node.bsky.social
www.biorxiv.org/content/10.1...

Sana Biotechnology's first-in-human study of hypoimmune-engineered deceased donor islets shows insulin production & immune evasion without immunosuppression #Diabetes #T1D #CellTherapy ir.sana.com/news-release...

2024 saw another record for bioRxiv postings. Thanks to all the CSHL staff, affiliates, authors, funders, and everyone who advocates for the project. Happy New Year and #letsmakethisthenorm ! 🧪

Molecular mechanisms underlying glucose-dependent insulinotropic polypeptide secretion in human duodenal organoids - Diabetologia Aims/hypothesis Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone secreted by enteroendocrine K cells in the proximal small intestine. This study aimed to explore the function ...

Up front & free to read in our Jan issue #editorspicks: Molecular mechanisms underlying glucose‑dependent insulinotropic polypeptide secretion in human duodenal organoids tinyurl.com/muc8sata