Siyuan Ding's Avatar

Siyuan Ding

@sding88.bsky.social

Assistant Professor of Molecular Microbiology at WashU

19 Followers  |  36 Following  |  6 Posts  |  Joined: 14.11.2024  |  1.4934

Latest posts by sding88.bsky.social on Bluesky

My first graduate student so it is truly a milestone for our lab! @washumicrobiology.bsky.social

24.04.2025 16:56 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Congratulations to Juhee on a stellar thesis defense! Clear, thoughtful, and thorough. Your work on rotavirus and SARS-CoV-2 reflects incredible perseverance. It's been a privilege watching you grow into an independent scientist. Wishing you all the best in your next chapter!πŸŽ“πŸ‘

24.04.2025 16:54 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Great collaborations with lots of people including folks from the Sibley, Liu, Shen, and Dermody labs. @washumicrobiology.bsky.social @natcommag.bsky.social

22.04.2025 14:27 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Its function is highly conserved in multiple cell types including primary human intestinal epithelial cells and hepatocytes and many vertebrate species.

I presented part of this data at ASV2023 almost two years ago! Very happy to see it comes to fruition! Truly a heroic effort by Gaopeng.

22.04.2025 14:26 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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SAMD9 senses cytosolic double-stranded nucleic acids in epithelial and mesenchymal cells to induce antiviral immunity Nature Communications - Sensing of cytosolic RNA or DNA can lead to innate responses, but little information is available for RNA/DNA dual sensors. Here the authors find SAMD9 as a potential dual...

We identified SAMD9 as a common sensor of cytosolic dsDNA and dsRNA molecules and a key host restriction factor of the infection of multiple dsRNA viruses in vitro and in vivo!
rdcu.be/eiJHa

22.04.2025 14:26 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Innate immune sensing of rotavirus by intestinal epithelial cells leads to diarrhea Hou etΒ al. demonstrate in an infant mouse model that innate immune sensing of enteric viruses induces IFN-Ξ» signaling, which downregulates an apical chloride exchanger that leads to increased intestin...

First post on Bluesky! Excited to share the first paper from our lab in 2025! cell.com/cell-host-mi.... Our study demonstrates that UV-inactivated replication-defective rotaviruses can cause diarrhea in neonatal mice, suggesting the host response also contributes to diarrhea to flush out the virus.

03.03.2025 17:53 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

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