Viktoria Flore

Huge thank you to my fantastic team for the creativity, energy, and teamwork that made this event possible - and to @bihatcharite.bsky.social and @mdc-bimsb.bsky.social for supporting our efforts to make science more open and accessible!

Had a great time welcoming visitors into our labs for @berlinscienceweek.bsky.social! It's always inspiring (and important!) to share our research with the public, and to see so much curiosity for how and why we do science 🧪🧬

Photos © Marc Beckmann / Berlin Science Week

Somatic mutation and selection at population scale - Nature A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.

Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...

Job announcement: The image has a solid dark blue background with a clean, minimal layout. In the top left corner, the word “JOBS” appears in all-capital red sans-serif text. Below, large white sans-serif text spans several lines and reads: “Three Independent Group Leaders in Bioengineering Approaches to Human Health m/f/d.” Near the bottom left, smaller white sans-serif text reads: “Apply by November 16, 2025,” followed by “Max Delbrück Center (Berlin-Buch)” in lighter gray. In the bottom right corner is the Max Delbrück Center logo in white and blue.

🚀 WE ARE HIRING 3️⃣ Independent Group Leaders for #mdcBerlin's new cutting-edge Bioengineering Cluster within our Biomedical Engineering Program.

Lead cutting-edge research at the interface of biology, engineering, and medicine in Berlin.

👉 Apply now: www.mdc-berlin.de/career/jobs/...

When women researchers publish, media attention doesn’t always follow Men-led papers receive more media coverage than women’s, new study finds

In an analysis of 1.2 million news stories about scholarly research, men-led papers were found to receive more attention overall and were heavily overrepresented in the top 5% of most covered studies. https://scim.ag/4o7l5a5

Ultra-high-scale cytometry-based cellular interaction mapping - Nature Methods Interact-omics, a high-throughput cytometry-based framework, resolves the cellular interaction landscape.

Excited to share the latest publication from my PhD with @simonhaas.bsky.social at @dkfz.bsky.social, out now in Nature Methods!

A big thanks to all co-authors, especially Lea Jopp-Saile, Schayan Yousefian and @viktoriaflore.bsky.social for all their hard work.
www.nature.com/articles/s41...

Thank you, sure!

Thank you Charles!

Two immune cells interacting with glowing connection, illustrating cell communication.

🧬 How do immune cells talk – and what happens when they don’t?

A new technology by Simon Haas & Daniel Hübschmann maps millions of cell contacts 🔬
It shows how immune responses shift in disease & therapy.

📊 A step toward personalized medicine!

🔗 Read more: www.mdc-berlin.de/news/press/h...

Wie Immunzellen kommunizieren, um Krankheiten und Krebs zu bekämpfen Ein interdisziplinäres Team aus Wissenschaftlerinnen und Wissenschaftlern vom Berlin Institute of Health in der Charité (BIH), vom Max Delbrück Center, dem Deutschen Krebsforschungszentrum (DKFZ), dem...

Ein Team aus Forschenden vom BIH, @mdc-berlin.bsky.social, DKFZ, HI-STEM und @qmul.bsky.social hat eine Technologie zur Entschlüsselung der Immunzell-Kommunikation entwickelt. Damit lässt sich unter anderem ablesen, warum Immuntherapien bei manchen Menschen wirken bei anderen nicht.
t1p.de/w3v16

Excited to share our latest paper @natmethods.nature.com
We present a high-throughput framework to map cellular interactions at ultra-high scale – broadly applicable from whole-organism immune response mapping to personalized therapy response prediction (1/4).
www.nature.com/articles/s41...

Huge thanks to my co-first authors @dom60.bsky.social, Lea Jopp-Saile, and Schayan Yousefian for the incredible teamwork, and of course to @simonhaas.bsky.social and Daniel Hübschmann for the invaluable support and guidance! (4/4)

GitHub - agSHaas/PICtR: Analysis of physically interacting cells (PICs) in flow cytometry data using R Analysis of physically interacting cells (PICs) in flow cytometry data using R - agSHaas/PICtR

The computational workflow we developed to analyze the physically interacting cells is available as an open-source R package 📦
Check it out here: github.com/agSHaas/PICtR and let me know what you think! (3/4)

Our framework can map millions of cells and their physical interactions using flow cytometry - even in existing datasets. We show how these interaction maps can help predict responses to immunotherapies and unravel immune cell communication during infections 🦠 (2/4)

Did you ever wonder what insights hide in the multiplets that are usually discarded in flow cytometry? 🫧 Find out in the first publication of my PhD, now out in Nature Methods! www.nature.com/articles/s41... (1/4)

Today is June 25. On this date in 1903 Marie Curie defended her doctoral thesis on radioactive substances at Université de la Sorbonne in Paris, becoming 1st woman in France to receive a doctoral degree. Image shows the thesis cover.

Thank you to everyone who helps make this such a great place to do research, and to @jungeakademie.bsky.social and @volkswagenstiftung.de for the initiative to highlight the scientists and leadership behind inspiring research environments 🔬🧬👩‍🔬

So proud that the Single Cell Focus Area was selected as one of the winners of the "Best Research Environment 2024" award!

Gruppenbild mit frühlichen Menschen. Foto: Die Junge Akademie/Bernd Brundert

🏆 Die 10 Gewinnerteams des Preises „Bestes #Forschungsumfeld 2024“ stehen fest! Aus fast 300 Bewerbungen wurden sie aus einer beeindruckenden Shortlist per Los gezogen. Wir gratulieren gemeinsam mit der @volkswagenstiftung.de! 🎉
Wer gewonnen hat? 👉 www.diejungeakademie.de/de/presse/be...

Excited to see our team among the finalists for the Best Research Environment award by the Junge Akademie! Fingers crossed for the draw 🤞

Postdoctoral Researcher

Hey #HemeSky and #EpiSci folks! We are hiring!
For our Translational Cancer Epigenomics team @dkfz.bsky.social and @nct-heidelberg.bsky.social we are looking for a talented postdoc interested in research on heme malignancies and #epigenetics.
Interested?
👉See jobs.dkfz.de/en/jobs/1676... or DM me!

🧬

Optimizing stem cell infusion timing in the prevention of acute graft-versus-host disease Adjusting the timing of stem cell infusion can reduce the incidence and severity of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. The rhythmic fluctuations in inflammation levels before infusion dictate subsequent T cell responses, which may be a key factor underlying outcomes based on the time of day that transplantation occurs.

Now online! Optimizing stem cell infusion timing in the prevention of acute graft-versus-host disease

75% of US scientists who answered Nature poll consider leaving More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.

We polled Nature readers to ask if they were thinking of leaving the US for jobs abroad. Three-quarters of them (who said they were US-based scientists) said yes. 🧪

www.nature.com/articles/d41...

Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U

Hey #LifeScience community have you seen that @altmetric.com now includes Bluesky as attention source 🎉

Bluesky is becoming a great place to share research and engage in scientific discussions! 🔬💬

#AcademicChatter #AcademicSky #AcademicBluesky #SciComm #ECRChat #PhDSky #MedSky

Introducing openRxiv: a new independent home for preprint sharing in the life sciences - openRxiv We’re thrilled to announce the launch of openRxiv as an independent nonprofit to oversee bioRxiv and medRxiv, the world’s leading preprint servers for life and health sciences. openRxiv ensures that r...

🎉 bioRxiv & medRxiv are now managed by openRxiv, a new independent nonprofit. This transition allows for more flexibility and innovation. Our mission remains being a free service to authors ensuring rapid sharing of scientific information before peer review.
ℹ️ openrxiv.org/introducing-...

Science Advances’ special issue on women’s health highlights a growing wave of research focusing on women’s unique biological and psychological experiences. Articles cover a range of studies from the interplay between menopause and Alzheimer’s risk to the menstrual cycle’s influence on the brain-heart connection. It also describes the opportunities pregnancy provides to research aspects of both physical and mental health. By prioritizing women’s unique physiological and psychological experiences, research can expand the frontiers of knowledge in ways that benefit everyone.

A special issue on #WomensHealth in #ScienceAdvances highlights a growing wave of research focusing on women’s unique biological and psychological experiences.

Learn more: scim.ag/3R59fPe (THREAD 🧵)

As we can expect PubMed dysfunction more and more or to be swamped with fake journals I suggest you get acquainted to this nice alternative: europepmc.org

Great teamwork with co-lead Niels Weinhold (@HDMyeloma) and a fantastic effort led by Raphael Lutz, Alexandra Poos, Llorenç Solé Boldo, Lukas John, and many others. Grateful for such an incredible team! 👏 #TeamScience 2/2