Patty Opresko

Congratulations!!

Riding for a cure: Pittsburgh cancer patients, doctors and families unite at 'Rush to Crush Cancer' For Mike Michna, completing an intense 15-mile bike ride at UPMC Hillman Cancer Center’s annual Rush to Crush Cancer event wasn’t just a physical...

Riding for a cure: Pittsburgh cancer patients, doctors and families unite at 'Rush to Crush Cancer'

Don't miss the next #EMGS webinar "Oxidative DNA Damage and Repair: Impacts and Methods of Detection," presented by the EMGS DNA Repair SIG. 🧬

Register Today: emgs-us.org/event/OxiDNAWEB

🏨Get the best rate to attend the #EMGS2025 Annual Meeting by booking through our room block at the Hyatt Regency Rochester! #GenomicsConference #EMGS #RochesterNY

Book Now: emgs-us.org/page/2025-ho...

🐦Register by May 31st for #EMGS2025 to take advantage of our Early Bird Registration prices!

Regular Member: $525
Early Career Investigator Member: $300
Student Member: $200
Emeritus: $200

Register Here: emgs-us.org/page/2025-re...

2025 EMGS Annual Meeting Genomic Health Innovations, Perspectives, and Progress Bloom in the Flower City

DID YOU KNOW? The Strong National Museum of Play in Rochester has the world’s largest collection of toys and games! 🪀👾

Join us in Rochester for #EMGS2025!

emgs-us.org/page/2025_EMGS

Tomorrow we have another exciting thesis defense from the Freudenthal lab!

This time it is our rock climbing, dessert loving, MD/PhD candidate Luis Cortez. 🥳DM for a zoom link if interested

The RAD52 double-ring remodels replication forks restricting fork reversal - Nature A head-to-head double-ring complex of the human multifunctional DNA repair protein RAD52 mediates protection of stalled replication forks during replication stress, protecting them from reversal by SM...

I ❤️ this new paper on RAD52 at replication forks, just published @nature.com. Cryo-EM reveals a unique double-ring structure that blocks reversal of replication forks.
www.nature.com/articles/s41...

🔊Don't miss the next #EMGS webinar: An Applied Genetic Toxicology Career in the Pharmaceutical Industry with Zhanna Sobol on April 8, 2025 at 12:00 PM EST!

Register Now: emgs-us.org/event/AGTCPI...

Excited to share our new pre-print. Direct, ensemble FRET assays developed by our lab reveal that assembly of Rad51 filaments at stalled replication sites via RPA/Rad51 exchange causes complete & irreversible PCNA unloading. Big implications for interplay between human DNA damage tolerance pathways

🐦The deadline for Early Bird Registration for #EMGS2025 has been extended to May 31, 2025!

Register Here: emgs-us.org/page/2025-re...

Free webinar! Join our expert panel for a thought-provoking discussion on the critical role of fundamental research in driving innovation and breakthroughs in cancer science ✨ #KeepResearchCurious

📅 25 March 16:00 CET
🌍 Zoom

us02web.zoom.us/webinar/regi...

The latest newsletter from the Sikora Lab and Front Range ILC is up! Features in this 'issue':

- Quick info on 'indirect' costs for advocates
- Info and registration link for our Spring '25 outreach event (on 4/11 - come join us!)
- Tracy's story re: full body MRI for cancer screening

#lobular

📢In response to current government restrictions, the #EMGS is pleased to offer government employees an extended deadline of May 15, 2025, for both abstract submissions and Early Bird registration for #EMGS2025.

Email emgshq@emgs-us.org for a discount code and more details.

By attacking science:

We are less safe because science informs national security and medical care.

We are less prosperous because science drives innovation and economic benefit.

We are less free because science and democracy depend on the liberty to ask questions, and seek and share knowledge.

Co-regulator activity of Mediator of DNA Damage Checkpoint 1 (MDC1) is associated with DNA repair dysfunction and PARP inhibitor sensitivity in lobular carcinoma of the breast Invasive lobular carcinoma of the breast (ILC) is typically estrogen receptor α (ER)-positive and presents with biomarkers of anti-estrogen sensitive disease, yet patients with ILC face particularly p...

One more bioRxiv update (v3) on MDC1 and DNA repair dysfunction in #lobular breast cancer:
www.biorxiv.org/content/10.1...

We worked w @foundationmedicine.bsky.social to see whether ILC mutations manifest as repair 'loss of function', and tumor genomes say... nope :). The ILC phenotype is unique!

🔊Get ready for a new #EMGS webinar: Lessons from AI: Predicting mutability in healthy human tissues on April 16, 2025 at 11:00 AM EST.

Register Now: emgs-us.org/event/AILess...

🔥🔥🔥Deadline for your abstract submission today! Don't miss out on the most exciting conference on The Ageing Genome in 2025!

I have written to Sen McCormick about my concerns on the defunding of US science. I finally received a response! He is supportive of research & thinks the F&A rates should be returned to previously negotiated rates! Thanks to @audreydrotos.bsky.social & @laurenkreeger.bsky.social for talking to him!

Annika rightfully points out that though this is positive, this is going to SERIOUSLY burden an NIH staff that is actively being further depleted.

Be nice to your SROs, POs, and GMSs, folks...

2025 Annual Meeting Registration - Environmental Mutagenesis and Genomics Society *Single Day registrants receive access to one day of the scientific program. Single Day Registration does not include access to social programs unless these programs occur on the registered day.

📢NEW YORK STUDENTS: We are offering a Free Student Day for local students at the #EMGS2025 Annual Meeting in Rochester! Come attend sessions, connect with peers, and explore career opportunities - FREE!

Just use the code STUDENT25DAY when you register!
emgs-us.org/page/2025-re...

EMGS celebrates Pi Day & Int’l Day of Mathematics on 3/14/25! We recognize the crucial role of math in environmental science & genomics research. Here’s to the power of numbers in advancing our field! #PiDay2025 #IDM2025

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.

That's not to mention the countless lives that biomedical research has saved.

Show me a better investment than that.
www.forbes.com/sites/michae...

Cancer knows no borders, and setbacks in one part of the world can have lasting consequences for #patients everywhere

The #EACR, and all co-signing national #cancer societies & foundations, stand in solidarity and offer our full support to our friends and colleagues in the US

#StandUpForScience 🧪

Great crowd in Pittsburgh Standing Up for Science.

Thanks to all of the other great speakers sharing their stories!

Environmental Mutagenesis and Genomics Society

🧬DID YOU KNOW? Rochester is a foodie haven with the famous ‘Garbage Plate’—a local culinary delight you must try!

Join us there for #EMGS2025! Register Now: emgs-us.org/event/2025EMGS

#GenomicsConference #RochesterScience

So excited to visit. See you soon !