@luijsterburglab.bsky.social
The Luijsterburg lab at the LUMC in Leiden investigates DNA repair mechanisms during gene transcription | luijsterburglab.org
New paper alert! π¨
We report two Cypriot XP-A patients with a mild phenotype caused by the homozygous c.389G>A (p.R130K) variant.
π The variant affects splicing, leading to reduced XPA mRNA/protein but residual NER activity.
www.sciencedirect.com/science/arti...
π’ ERCC1-hepatorenal syndrome is defined as a severe, multisystem DNA repair disorder associated with high morbidity and mortality, including an elevated cancer risk. 𧬠@luijsterburglab.bsky.social
www.nature.com/articles/s41...
Dive into the step-by-step choreography of transcription-coupled DNA repair.
In our new review published in Nature Cell Biology, we explore what we know and whatβs next in this exciting field of research!
www.nature.com/articles/s41...
Happy to share I have been promoted to Full Professor of Transcription and DNA Repair! Huge thanks to all current and former Luijsterburg Lab members. Your hard work, dedication, and inspiring spirit made this possible! π₯π§¬π www.luijsterburglab.org
01.08.2025 07:14 β π 67 π 1 π¬ 8 π 0
Are transcription-associated histone marks involved in restoring transcription after DNA damage in human cells?
Read the surprising outcome in our new preprint π
www.biorxiv.org/content/10.1...
Very proud of this international collaborative team effort published in EJHG defining ERCC1-hepatorenal syndrome as a severe multisystem DNA repair disorder with high mortality and pediatric liver cancer risk. Thanks to all families and collaborators.
www.nature.com/articles/s41...
π’ Only 2 more days left until the early bird registration deadline! Secure your spot and join us at the 8th EU-US Conference on Endogenous DNA Damage and Repair!
23.05.2025 12:03 β π 2 π 2 π¬ 0 π 1This is an in-person meeting. A key aspect is community building and networking.
09.04.2025 19:33 β π 0 π 0 π¬ 0 π 0@puckknipscheer.bsky.social, @luijsterburglab.bsky.social, @marcelvanvugt.bsky.social, @sylvie-noordermeer.bsky.social, @titiasixma.bsky.social, @marcelvanvugt.bsky.social, @marteijnlab.bsky.social
09.04.2025 08:24 β π 0 π 2 π¬ 0 π 0@evisoutoglou.bsky.social, @jstingele.bsky.social, @jsvejstrup.bsky.social, @nitikataneja.bsky.social, @haicovanattikum.bsky.social, @thedownslab.bsky.social, @jacqjacobs.bsky.social
09.04.2025 08:24 β π 2 π 0 π¬ 0 π 0@andrewblackford.bsky.social, @cejkalab.bsky.social, @rosschapmanlab.bsky.social, @durocher1.bsky.social, @duxinlab.bsky.social, @kfugger.bsky.social, @serenanikzainal.bsky.social, @icrlordlab.bsky.social, @lapassmore.bsky.social, @bjornschumacher.bsky.social, @agnelsfeir.bsky.social
09.04.2025 08:23 β π 0 π 0 π¬ 0 π 0
A must for all DNA repair aficionados!
Egmond DNA Repair Meeting β April 19β24, 2026 π³π±
βοΈ Confirmed top speakers
βοΈ Ample opportunities for talks & posters
Donβt miss it: dnarepairmeeting-egmond2026.com
Awesome work, Nima, as always! I call (R)DIBs on choosing the celebratory drinks next time we meet.
04.03.2025 13:04 β π 0 π 0 π¬ 2 π 0
It was wonderful to have our lab symposium yesterday, filled with great science, new ideas, good company, and delicious food. What a pleasure it is to work with such a fantastic group of people!
18.02.2025 11:22 β π 6 π 0 π¬ 1 π 0The abstract mentions DNA breaks, which are not repaired by TC-NER. This could be a form of transcription-coupled DNA break repair, perhaps.
24.01.2025 20:33 β π 0 π 0 π¬ 0 π 0Our letter-to-the-editor providing evidence that ARK2N is not a core factor in transcription-coupled DNA repair is now online in PNAS | www.pnas.org/doi/10.1073/...
24.01.2025 19:43 β π 10 π 1 π¬ 1 π 0Congratulations, Kinga!
28.12.2024 11:37 β π 1 π 0 π¬ 0 π 0@haicovanattikum.bsky.social @thedownslab.bsky.social @puckknipscheer.bsky.social @titiasixma.bsky.social @marcelvanvugt.bsky.social
23.12.2024 12:48 β π 0 π 0 π¬ 0 π 0
Mark your calendar: the next Egmond DNA repair meeting will take place in 2026 from April 19 - 24!
You can pre-register to receive announcement here: forms.lumc.nl/lumc2/Egmond
Registration will open by June 2025/
Lovely Christmas party with the @luijsterburglab.bsky.social ! Looking forward to great science with this amazing group in 2025.
14.12.2024 01:10 β π 13 π 0 π¬ 0 π 0Congratulations, Lucas, beautiful work! Any role for IWS1 in this process?
12.12.2024 21:59 β π 2 π 0 π¬ 1 π 0Awesome, congratulations Gideon!
06.12.2024 08:02 β π 0 π 0 π¬ 1 π 0Congratulations Basil! Welcome to EMBO-YIP.
03.12.2024 22:31 β π 1 π 0 π¬ 1 π 0Awesome, congratulations, Thom!
03.12.2024 22:05 β π 1 π 0 π¬ 0 π 0Congrats Tineke, that's awesome!
03.12.2024 21:59 β π 1 π 0 π¬ 0 π 0Our review on the recently discovered transcription-coupled DPC repair pathway is out in Trends in Cell Biology. Yet another wonderful collaboration with @cjcarnie.bsky.social and Steve Jackson.
02.12.2024 07:51 β π 38 π 5 π¬ 1 π 0Awesome work, Simon & team! Congratulations.
26.11.2024 21:57 β π 1 π 0 π¬ 0 π 0
It's a wrap! The 12th 3R+3C meeting in Fukuoka was amazing. Looking forward to the next edition!
22.11.2024 13:00 β π 11 π 0 π¬ 0 π 0Thanks Ben!
20.11.2024 23:41 β π 0 π 0 π¬ 0 π 0Dank je wel Luuk!
19.11.2024 09:51 β π 1 π 0 π¬ 0 π 0
