Thanh Nguyen

The expanding repertoire of ESCRT functions in cell biology and disease - Nature This Review examines recently gained insights into the roles of ESCRT complexes in viral infection, immunity, cancer and neurological disease.

The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem

Mitochondrial fumarate inhibits Parkin-mediated mitophagy Ham et al. identify fumarate as an endogenous inhibitor of PINK1-Parkin-mediated mitophagy through succination of specific cysteine residues in Parkin. This metabolite-induced modification disrupts Pa...

Mitochondrial fumarate inhibits Parkin-mediated mitophagy: Molecular Cell www.cell.com/molecular-ce...

Colorful background with white text in the lower left that reads "Micro e-Learning Program“ above the main title "Open Science Best Practices Across the Research Lifecycle.” The GP2 logo is in the top right corner.

Check out GP2's latest Micro e-Learning video on #openscience. You'll learn what open science is, why it matters in today's research landscape, and how it promotes transparency, collaboration, and accessibility.

📺 Watch to learn more: www.youtube.com/watch?v=hTzZ...

New tenure track assistant professor position in molecular microbiology in our department @dmf-unil.bsky.social @unil.bsky.social! We are casting a wide net for an experimental molecular microbiologist. Apply here: wwwfbm.unil.ch/releve/appli...

Kinome screening identifies integrated stress response kinase EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling EIF2AK1/HRI kinase negatively regulates PINK1 mitophagy.

Excited that our work revealing the regulation of PINK1 by ISR pathway, is out now! A new regulatory axis in mitophagy and mitochondrial quality control #mitophagy #Pink1 #mitochondria #ISR #Neurodegeneration
@mrcppu.bsky.social

www.science.org/doi/10.1126/...

Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025!
📍 Location: Lorne, Victoria, Australia
🌐 Register now: www.isa11.org
Join us for five inspiring days of cutting-edge autophagy research and networking opportunities.

The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage Nature Cell Biology - Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal...

"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology
rdcu.be/ehbaL

Changes to the 2026 and 2027 Work Programmes With the launch of the competitions for grants under ERC Work Programme 2026 in July of this year, several changes to the submission of applications and the evaluation of proposals will apply. The mai...

Important changes on @erc.europa.eu grants‼️Grant structure & most importantly eligibility timeframes (10 years for starting, 15 years for consolidator post PhD-but you can have them only once) changes: erc.europa.eu/news-events/...

A white background with a colorful frame. In the center of the graphic, dark blue text reads, “New preprint from Team Chen." The ASAP logo is in the bottom right corner.

Using data from the PPMI cohort, CRN Team Chen tested whether baseline α-syn seeding activity was associated with disease progression in sporadic, LRRK2, & GBA PD & found no statistically significant associations.

🔗 Read their recent #preprint: www.medrxiv.org/content/10.1...

11th International Symposium on Autophagy

I'm looking forward to attending the 11th International Symposium on #Autophagy. The last one in Sapporo, Japan was a great meeting and that is set to continue in Lorne, Victoria, in November of this year. Early bird rego closes August 29 here: www.isa11.org #isa11

VPS15 is a GTP binding pseudokinase.

CRN Team Hurley elucidated a structural pathway of enzyme activation through cryo-EM analysis of PI3KC3-C1, showing that the activation of the VPS34 lipid kinase complexes is mediated by the myristoylated, GTP-binding pseudokinase VPS15.

🔗 Read their full #publication: shorturl.at/hdwih

Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex Nature Structural & Molecular Biology, Published online: 29 May 2025; doi:10.1038/s41594-025-01557-xAutophagy is initiated by the Unc-51-like kinase protein kinase complex (ULK1C) and class III phosphatidylinositol 3-OH kinase complex I (PI3KC3-C1). Here, the authors reveal the structure of the 2:1:1 core of ULK1C and its complex with PI3KC3-C1. ULK1C transitions to a 2:2:2 complex in the presence of PI3KC3-C1, suggesting a mechanism for autophagy induction.

ICYMI: New online: Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex

Special thanks to the organising committee members and Dorotea Fracchiolla for the beautiful poster!

🎓Plus! You’re invited to stay on for the Australian Ubiquitin Summit (chaired by David Komander), which runs back-to-back with the ISA from 20–23 November 2025 in the same beautiful location. Register for the Ubiquitin Summit here: lnkd.in/gTj2a6vp

🦘Make the most of your time in Australia! Choose from a range of optional excursions to experience the breathtaking scenery and unique wildlife of Australia.

Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025!
📍 Location: Lorne, Victoria, Australia
🌐 Register now: www.isa11.org
Join us for five inspiring days of cutting-edge autophagy research and networking opportunities.

NDP52 and its emerging role in pathogenesis - Cell Death & Disease Cell Death & Disease - NDP52 and its emerging role in pathogenesis

www.nature.com/articles/s41...

An image capturing 3 people discussing, presenting, and interacting with posters.

An image capturing a group of people walking toward the camera on a bright sunny day.

An image capturing a person looking up intently, with rows of people behind them looking in the same direction.

An image capturing 4 people sitting in brown armchairs participating in a panel in front of an audience. The ASAP and CRN logos are present in the backdrop.

🎉 The CRN Collaborative Meeting brought together ~400 scientists, advocates, & people living with #PD.

From groundbreaking discoveries to powerful stories, this year’s meeting wasn’t just about research; it was about impact.

🔗 Check out the recap blog: parkinsonsroadmap.org/news/highlig...

Confocal imaging identifies AAV1, AAV7, AAV-DJ/8, and AAV-rh10 as efficient AAV serotypes for OSN transduction.

CRN Team Schlossmacher utilized serial confocal imaging and single-nucleus RNA sequencing to evaluate the efficacy of 11 different AAV serotypes in transducing murine olfactory sensory neurons via non-invasive nasal inoculation.

🔗 Check out their #publication: www.frontiersin.org/journals/neu...

Niemi lab and @washubbsb.bsky.social graduate student Youmian Yan gave a fantastic presentation on her work at the @asbmb.bsky.social meeting in Chicago! #ProudPI (photo credit to @kerikozul.bsky.social)

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#Autophagy and #mTOR papers and pre-prints from last week, have a peep!

biomed.news/bims-auttor/...

We're learning more about how cells take out the trash - ABC listen Our cells are smart – they’re able to get rid of damaged parts and recycle useful parts to keep us healthy. This process seems to break down in conditions like Parkinson’s and Alzheimer’s disease, an...

🧠🗑️ Just like we take out the rubbish, our cells use autophagy to clear waste. When it fails, conditions like #ParkinsonsDisease can arise. WEHI’s Prof Michael Lazarou joins Radio National to discuss his new research & potential treatments.

@lazaroulab.bsky.social

www.abc.net.au/listen/progr...

Just wrapped up #FCQC2025! Over 300 scientists gathered to explore autophagy, disease pathogenesis & more. Huge thanks to @idikic.bsky.social, Volker Doetsch, Maike Windbergs & all who made this conference a success! See you at #FCQC2027!
@sfb1177.bsky.social @proxidrugs.bsky.social

Trying to find all the metabolism/mito folks on here, so i created a starter pack. Please suggest anyone I missed!
go.bsky.app/C2t7snh

Please add me!

Excited to see work led by @autophazeke.bsky.social, @minghaochen.bsky.social, Thanh Nguyen, and Ainara Claveras out in @science.org today, the culmination of a 15-year project to understand structurally how the synthesis of the critical lipid of autophagy, PI3P, is regulated. tinyurl.com/ywvjh8u4

Fantastic initiative by @science.org and Westlake University: a series of themed online symposia on hot topics
Kicking off with Mitochondria, March 19, 13:00 CET
Register us02web.zoom.us/webinar/regi...
Speakers: Patrick Chinnery, Luca Scorrano, Aleksandra Trifunovic, Min Jiang, @smhsci.bsky.social

Structure of human mitochondrial pyruvate carrier - what a milestone by the wonderful Dan Ma's lab from Westlake! Using Xudong Wu's expertise in nanoantibodies, they capture MPC during transport, revealing its pseudo-symmetric model and alternate opening mechanism with functional cardiolipin. Bravo!

a penguin wearing a bear hat and a blue sweater is jumping in the air ALT: a penguin wearing a bear hat and a blue sweater is jumping in the air

The next frontier in #autophagy is understanding how it functions across cell types to maintain organismal homeostasis. w/ @moritznowack.bsky.social lab, we present TWO #preprint on cell type spec. autophagy in root hairs‼️ #plantscience www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

Come to St. Louis this summer for the United Mitochondrial Disease Foundation MitoMed 2025 Conference! We have a fantastic line up with lots of opportunities for short talks. We're also running a Masterclass for Early Career Investigators. More info here: www.umdfconference.org