Theo Hirsch

4-panel comic. (1) [Person 1 with ponytail flanked by person with short hair and another person speaking into microphone at podium] PERSON 1: In the early 2010s, researchers found that many major scientific results couldn’t be reproduced. (2) PERSON 1: Over a decade into the replication crisis, we wanted to see if today’s studies have become more robust. (3) PERSON 1: Unfortunately, our replication analysis has found exactly the same problems that those 2010s researchers did. (4) [newspaper with image of speakers from previous panels] Headline: Replication Crisis Solved

Replication Crisis

xkcd.com/3117/

Check out my editorial about immune exclusion in hepatoblastoma and a possible role of beta-catenin:
www.sciencedirect.com/science/arti...

Thank you @easlnews.bsky.social for giving me the opportunity to present our work on hepatoblastoma genomics and future therapeuties in Amsterdam, together with my mentor @zucmanrossi.bsky.social
@crcordeliers.bsky.social

🔙 on our Hepatology and Liver Transplantation Days!

🤝 We had the pleasure of welcoming @tz-hirsch.bsky.social for a presentation titled: Evolution of Hepatoblastoma: From #Liver Development to Chemoresistance.

🧫 His talk sparked dynamic discussions during the session on #hepatic #pathogenesis.

Thank you @ihuhepatolyon.bsky.social for the invitation and the opportunity to present our team work on hepatoblastoma evolution, in a nice castle in Lyon! #FunGeST @crcordeliers.bsky.social

🚀 C'est parti pour le Young Investigators Mentoring Symposium au CRC, organisé par le consortium GENIAL en collaboration avec le laboratoire de @zucmanrossi.bsky.social.
Une occasion de favoriser l'échange, la collaboration et la visibilité des talents émergents dans le monde de la recherche!

Slide presenting the seminar

Serge Romana with his introduction slide

Peter Campbell and his slides

Great scientific day about mosaicism 👾 at @institutimagine.bsky.social including inspiring talks from Serge Romana and Peter Campbell

SIOPEL conference stage

Cardiff castle

Cardiff castle with colleagues

Cardiff view

Thrilled to reconnect with colleagues from around the globe at the SIOPEL meeting in Cardiff! Working together to better understand and treat childhood liver cancer. 🌍 @crcordeliers.bsky.social

Tools like our Single-cell #PediatricCancer Atlas (ScPCA) Portal make data widely available and easier for researchers to use for their own experiments. Currently, you can explore and download data from 700 samples across 55 cancer types at scpca.alexslemonade.org!

Re-upping these two #CancerResearch 🧪 starter packs for any new arrivals

go.bsky.app/FEoaJMc
go.bsky.app/6EcjWNA

Together they include PIs, oncologists, students, postdocs, journals, patient advocates, and organizations supporting cancer research 🧪🔬⚕️

Both are full - sorry I can't add any more 😅

Excited to share our lab's first preprint: we used spatial transcriptomics to dissect how aging disrupts the cycling ovary! 🧵

This was an incredible team effort w/ @jennifergarrison.bsky.social #TammyLan @davidsebfischer.bsky.social #AlisonKochersberger #RuthRaichur #SophiaSzady

Concert hall with rapper Gringe on stage

I ran a half marathon and I analyse whole genome sequencing data, does that count?

SpatialLeiden - Spatially-aware Leiden clustering Clustering can identify the natural structure that is inherent to measured data. For single-cell omics, clustering finds cells with similar molecular phenotype after which cell types are annotated. Le...

Try out SpatialLeiden for identifying spatial domains/clusters in your #SpatialTranscriptomics data: www.biorxiv.org/content/10.1...
github.com/HiDiHlabs/sp...
It's as easy as Leiden, but as performant as the best in class. Give it a try and let us know if it works for you!

My first post on Bluesky ! I officially announce that after 15 years at the PARCC HEGP, the Favier Lab has moved today to the Centre de Recherche des Cordeliers. We are very exited to be part of such a prestigious institute ! A new era begins!🤩

Only a subset of patients respond to immunotherapy

Why? Which ones?

We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.

www.nature.com/articles/s41...

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️

So how can we ever achieve #gender #equality?

We discuss various strategies in this #Cell Commentary

#WomeninSTEM

www.cell.com/cell/fulltex...
🧵 1/

Children who develop two independent tumors during childhood are extremely rare

We wanted to see if our genomic technologies could shed light into those exceptional cases.

Read about it in this recent paper:
tinyurl.com/yt9m584d

To target, to escape, perchance to cure: Borrowing a page from cancer’s playbook, scientists learn to evade their own therapies Borrowing a page from cancer’s playbook, scientists learn to evade their own therapies

A paradigm-shifting concept 😮 When there’s no mutated target for your CAR-T cells, why not target the wild-type and mutate all non-cancer cells to protect them?
www.science.org/doi/10.1126/...

We recently announced a dual new release of intOGen and boostDM

Computational analysis of 33,218 tumor genomes to identify cancer genes and driver mutations

➡️ Compendium of Cancer Driver Genes - www.intogen.org

➡️ In Silico Saturation Mutagenesis of Cancer Genes - www.intogen.org/boostdm

A developmental biliary lineage program cooperates with Wnt activation to promote cell proliferation in hepatoblastoma - Nature Communications Epigenetic causes of intra-tumoural heterogeneity are crucial in paediatric cancers with low mutation rates, such as hepatoblastoma. Here, the authors characterise transcriptional heterogeneity in hep...

Happy to be here & share our work on hepatoblastoma - using transcriptomics and patient-derived tumoroids to identify embryonic biliary transcription factor SOX4 as a modifier of Wnt activation & proliferation - published today in #NatComms @natureportfolio.bsky.social www.nature.com/articles/s41...

Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas - Nature Cancer Wu et al. perform single-cell analyses to explore the switch from low-grade to high-grade isocitrate-dehydrogenase-mutant glioma and show that it is characterized by oligodendrocyte progenitor cell-li...

Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas - Nature Cancer 🧪

www.nature.com/articles/s43...

Let's build a starter pack for childhood cancer research.
Please send a message to be added! 🎗️
go.bsky.app/Tpd9QnM

Tu peux m’ajouter stp ?

It works fine now, sorry for the trouble!

Congrats, it seems really interesting! Just for information, I struggle to get the pdf from biorxiv ("Highwire Fatal Error")

NOTCH1 Drives Sexually Dimorphic Immune Responses in Hepatocellular Carcinoma - by Katherine Lindblad1, @amaialujambio.bsky.social and colleagues doi.org/10.1158/2159...

Hi Ben, can you please add me?

Somatic mutation and selection at epidemiological scale As we age, many tissues become colonised by microscopic clones carrying somatic driver mutations ([1][1]–[10][2]. Some of these clones represent a first step towards cancer whereas others may contribu...

Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...

1/ 🧬 Single-cell genomics reveals biological variations beyond cell types. Unveiling these in separate latent dim’s is known as disentanglement. Led by @AmirAliMoinfar, we develop DRVI to learn nonlinear, disentangled & interpretable latent spaces.
biorxiv.org/content/10.1101/2024.11.06.622266v1