Signa Vitae

🩺A year of impact in #CriticalCare!

From groundbreaking sepsis insights to #AI saving lives in the #EmergencyDepartment explore the top Signa Vitae papers of 2024, redefining how we care for the critically ill

🔗 doi.org/10.22514/sv....

#ICU #Sepsis #Anesthesia #FOAMed #Meded

💨 Every breath in the OR has a climate cost

💤Anesthetic gasses can warm the planet up to 2,500× more than CO₂!

📚This new review calls for a green revolution in anesthesia low-flow, TIVA, and regional techniques can slash emissions by >80%

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🧪Elevated LHR, SIRI, and SII values at ICU admission independently predict hyperactive delirium

🔥Simple inflammatory biomarkers may enable early risk stratification and improve patient outcomes

🔗 doi.org/10.22514/sv.2025.133

#CriticalCare #delirium #Biomarkers #inflammation #ICU #FOAMed #MedEd

🥑Can diet protect the heart?

A multicenter study finds omega-3 intake cuts sudden cardiac arrest risk in men by 50%, but not in women

♂️♀️Sex-specific differences may guide tailored prevention.

🔗 doi.org/10.22514/sv.2025.128

#cardiacarrest #diet #cardiology #FOAMed

🧒In pediatric trauma, the lactate-to-albumin ratio (LAR) strongly predicts mortality

🧪Early measurement can identify high-risk patients and guide life saving decisions in the PICU

🔗 doi.org/10.22514/sv....

#Pediatrics #peds #TraumaCare #CriticalCare#ICU #FOAMed #Meded

👁️ New in Signa Vitae: CT-measured optic nerve sheath diameter (ONSD) helps spot methanol intoxication & predict outcomes

Cut-off 5.57 mm → 85% sens., 80% spec.

🚑A potential game changer in the ED

🔗 doi.org/10.22514/sv.2025.129

#EmergencyMedicine #Toxicology #CriticalCare

💔 In intensive care, every line counts.

👶 1 in 3 central venous catheters in critically ill children are misplaced — risking complications when they’re most vulnerable.

✨ Smarter placement could save young lives.

🔗 doi.org/10.22514/sv....

#PICU #Pediatrics #PatientSafety

📊 Our retrospective study finds no difference in hemodynamic stability between low-flow sevoflurane and desflurane during laparoscopic sleeve gastrectomy

Evidence supports low-flow anesthesia as safe & feasible in obese patients

🔗 www.signavitae.com/articles/10.22514/sv.2025

🌀 After the 2023 Türkiye earthquakes, cases of scabies & other itchy skin diseases surged in overcrowded shelters

🧼Better hygiene, clean water & safer housing are vital to protect survivors

🔗 doi.org/10.22514/sv....

#Earthquake #Health #dermatology #Turkiye #Hygiene

🤖Can AI help doctors read and interpret blood tests?

A new study shows #ChatGPT can interpret arterial blood gases as well as physicians

💡This could lighten workloads and support faster, safer care in the ICU

🔗 doi.org/10.22514/sv.2025.138

#Healthcare #AI #FutureOfMedicine #MedEd

🌍💉 Should anesthetic gases like desflurane really be banned for their climate impact?

This new editorial argues that their effect on global temperature is negligible & reversible raising questions about science vs policy in medicine

🔗 doi.org/10.22514/sv....

#Climatechange

🚑 Rapid sequence intubation is a lifesaving procedure but hypoxemia during intubation can be deadly

❓Can HFNC make intubation safer?

A new review explores how this technique could help patients at risk of hypoxemia

🔗 doi.org/10.22514/sv....

#Criticalcare #anesthesia #icu #emergenymeddicine

😷 Feeling “just weak” or “tired” can land many older adults in the ER.
But these non-specific complaints don’t always mean worse outcomes.
Our study across 8 hospitals shows they often stay longer in the ED—but need ICU less often than those with clear symptoms.

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#elderly

In the September issue of SIGNA VITAE there will be 4 articles on volatile anesthesia!

Two of them on the global warming potentials debate

Stay tuned on www.signavitae.com and on your favorite social media

#climatechange #globalwarming #anesthesia #volatile #emergency

🧠 Pediatric stroke is rare but devastating
This case links Epstein-Barr virus to focal cerebral arteriopathy, urging clinicians to consider viral triggers in acute pediatric neurologic events
⏱ Early imaging Full recovery
www.signavitae.com/articles/10.22514/sv.2025.119
#Neurology #EmergencyMedicine

This study shows gastric ultrasound correlates well with residual volume even across different feeding protocols

✅ Less interruption ✅ More patient comfort

Ultrasound might just be the new standard in ICU nutritional monitoring

🔗www.signavitae.com/articles/10.22514/sv.2025.111

#CriticalCare #ICU

🫁 Life after steroids?

This real-world study shows rapid improvement in asthma control and quality of life after starting benralizumab — even in patients with comorbidities.

The message is clear: the biologic era in severe asthma is here to stay

🔗 www.signavitae.com/articles/10....

🧠POD is a surgeon’s nightmare. But can better pain control help?

💊This RCT finds that while oxycodone didn’t reduce delirium compared to sufentanil, it did improve pain scores and reduced side effects

🔗www.signavitae.com/articles/10.22514/sv.2025.108

#Delirium #PostOpCare #Anesthesia #MedEd

🫁Too deep too shallow both dangerous

🧒Intubating a child is not just about skill it’s about precision

This review maps the latest evidence on how to get it right, from formulas to ultrasound to palpation

#pediatric #anesthesia #pedsanes

🔗 www.signavitae.com/articles/10.22514/sv.2025.120

🚑Korea’s BLS research is evolving: less focus on experience, more on standardized, tech-driven training

🫀The goal? Stronger skills, faster response, better survival in cardiac arrest

🔗https://doi.org/10.22514/sv.2025.117

#BLS #CPR #emergencymedicine #emergency #Paramedic #MedEd #FOAMed

🫘Is 80 mmHg really the magic number for kidney protection?

Our review shows it’s not that simple, the real lower limit of renal autoregulation may be far lower, and disease-specific

❓Time to rethink blood pressure targets

🔗 doi.org/10.22514/sv.2025.001

#CriticalCare #Anesthesia

🫀In acute type A aortic dissection surgery, Rh-positive blood type is linked to better in-hospital survival

🩸Could your blood type influence surgical outcomes?

🔗 doi.org/10.22514/sv....

#AorticDissection #VascularSurgery #Blood #surgery #anesthesia #criticalcare

🧠New biomarker alert in TBI!

Serum SIRT6 levels strongly predict neurological impairment and prognosis in early traumatic brain injury

Strong correlations with GOS & NIHSS

❓Could SIRT6 be the key to early intervention?

🔗 doi.org/10.22514/sv....

#NeuroTrauma #CriticalCare #Brain #Trauma #FOAMed

Reads the full article at:
🔗 www.signavitae.com/articles/10....

💉 Regional anesthesia is revolutionizing cardiothoracic surgery!

Reducing opioids speeds recovery and improves outcomes

Paravertebral blocks, erector spinae blocks, and wound catheter anesthesia are becoming the go-to for pain management

💊Less opioid = less side effects!

⏱️ Time is muscle in cardiac emergencies!

In conditions like MI, arrhythmias, and heart failure, every minute counts

Early recognition + rapid intervention = better outcomes

Read more on timely interventions in our latest review:
www.signavitae.com/articles/10.22514/sv.2025.093

#CardiacEmergency

🧪 Can presepsin guide sepsis diagnosis in patients with organ failure, even with kidney dysfunction?

🫘This study shows it can, with tailored cutoff values for hypercreatinemia

💡 Prognostic power beats CRP & rivals PCT

🔗 www.signavitae.com/articles/10.22514/sv.2023.044

#Sepsis #EmergencyMedicine

❓Which biomarkers best predict survival after in-hospital cardiac arrest?

This study highlights GPR, lactate, NLR & PLR as independent predictors

📈 GPR >57.8 = higher mortality risk
🥇 Lactate had the strongest predictive value

🔗 www.signavitae.com/articles/10.22514/sv.2025.097

#cardiacarrest

🚨Solid organ transplant patients in the ED?

🩺Don’t miss this comprehensive update on diagnosis, infection management, drug interactions & organ-specific pitfalls

A must-read for emergency & acute care teams

🔗 www.signavitae.com/articles/10.22514/sv.2025.092

#TransplantMedicine #EmergencyMedicine

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