Marten Chaillet

Open Source Power We have to talk about open source licensing.

Anti-fascistic software is made possible by pro-labor licensing.

I've been trying to write this piece for years. Every time I get started I'm just overwhelmed with paralyzing visions of the FOSS commentariat accusing me of WrongThink.

But I'm tired and we urgently need to get our shit together.

De onvermijdelijkheid van zeespiegelstijging Door de sterke opwarming van de Zuidelijke Oceaan smelten gletsjers aan de rand van het Antarctische continent aan de onderkant snel weg. Hierdoor worden de landinwaarts gelegen ijsmassa’s instabiel,

Door de sterke opwarming van de Zuidelijke Oceaan smelten gletsjers aan de rand van het Antarctische continent aan de onderkant snel weg. Hierdoor worden de landinwaarts gelegen ijsmassa’s instabiel, en storten uiteindelijk in.

Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬

Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠

www.uu.nl/en/news/33-m...

Congrats to the applicants! Great news for EM in the Netherlands

Wilders deelt berichten die suggereren dat Kiesraad niet onafhankelijk is, instantie weerspreekt beschuldiging In dit liveblog lees je het laatste politieke nieuws over de uitslag van de Tweede Kamerverkiezingen.

Hoe kan je zo zijn... gewoon triest

nos.nl/collectie/14...

why I like squash and merge 😎

CryoJAX - A Cryo-Electron Microscopy Image Simulation Library in JAX www.biorxiv.org/content/10.1101/2025.10.23.682564v1 #cryoEM

Does anybody have a working protocol for a pipeline including aretomo3 to pytom-tm to warptools for #STA? I would ideally like to use M for the final refinements instead of being confined to relion5. Any suggestions/resources would be welcome! #teamtomo #cryoet #cryoem

Op sociale media delen PVV-fanaccounts levensechte AI-beelden, veelal van knappe, blonde vrouwen die worden bedreigd door migranten. Deze pagina’s blijken te worden beheerd door minstens twee PVV-Kamerleden.
👉 buff.ly/MFNFcU3

Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.

www.sciencedirect.com/science/arti...

Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.

Muyuan Chen has turned structural biology into an immersive experience with his new video game Meowtabolism, now available on Steam.
Try the demo here: store.steampowered.com/app/4045010/...
Give Muyuan feedback: steamcommunity.com/app/4045010
#ScienceGaming #StructuralBiology #CryoEM #STEMOutreach

But there’s a curious loose end to this story. Scientists have been looking at PSII organization in thylakoids for over 50 years (including some really stunning freeze fracture 🔬😍). Sometimes PSII looks randomly oriented, and other times it forms extended 2D crystalline arrays in the membrane 💠

9/🧵

It works but you still need to be careful with heating the sauce after blending. I thought it was too watery and tried to reduce it a bit while tossing with the pasta, still started to clump

👀 this is really interesting!

PSA: 9 billion USD in research funds stolen by publishers over a 5 year period for open access fees - this takes away from your ability to pay your people what they are worth. Preprints forever.

2025 Ig Nobel Prize for Perfect Pasta Sauce The Ig Nobel Prize honors research that first makes people laugh, then makes them think. Its 35th award ceremony possibly also makes people hungry: ISTA physicist Fabrizio Olmeda and colleagues resear...

This is the research we need 😋 I have been struggling for years to make reliable cacio e pepe, can't wait to try it out
ista.ac.at/en/news/2025...

Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching https://www.biorxiv.org/content/10.1101/2025.09.11.675606v1

Together with colleagues at the Dept. of Microsystems Engineering, we are looking for a PhD student to develop methods for femtoliter-scale sample dispensing in cryoEM sample preparation.

edu.nl/h436k

If you like interdisciplinary research & fascinating physics at ultrasmall scales, please apply!

Leopard-EM: An extensible 2DTM package to accelerate in situ structural biology The ability to generate high-resolution views of cells with cryogenic electron microscopy (cryo-EM) can reveal the molecular mechanisms of biological processes in their native cellular context. The re...

First pre-print from the Lucas Lab led by Matthew Giammar and @joshdcryoem.bsky.social online today! We develop a new, extensible Python implementation of 2DTM and apply it to build pixel size optimization, constrained search and characterize molecular motions in situ www.biorxiv.org/content/10.1...

Mitochondria finally made the headlines, yay!

Oh wait, ... oh no ....

Larger teams worsen academic career prospects As teams grow, new Ph.D. graduates are less likely to land tenure-track jobs and more likely to leave science—especially women and international researchers

As teams grow, new Ph.D. graduates are less likely to land tenure-track jobs and more likely to leave science—especially women and international researchers, according to research from last year. https://scim.ag/3JHinJs #ScienceMagArchives

PVV-programma wil trans mensen erkenning ontnemen, docenten screenen op "politieke neutraliteit", XR en Antifa als "terroristisch" aanmerken en verbieden, "Alle Syriërs terug", uit EVRM en VN-Vluchtelingenverdrag, verbod op "links-liberale seksuele indoctrinatie".

NOS: "er zijn scherpe randjes af".

It's hard to express how much gratitude I have to everyone involved in the journey, both mine and @napari.org's, that has led to this point. #EurekaPrizes A small attempt below: 👇

ASS is short for acephalic spermatozoa syndrome in which head and tail of sperm are detached⛓️‍💥, commonly caused by mutations in the gene encoding for SUN5. Using in situ cryo-ET❄️🔬 we find that SUN5 forms a protein lattice in the nuclear envelope (NE) at the head-tail junction of mammalian sperm.1/4

CryoET tomogram with the gap junction (green), ribosomes (cyan) and microtubules (pink)

In our latest preprint on bioRxiv, we present the in situ structure of
the human gap junction at 14 Å resolution using cryo-ET.

The structure provides a blueprint for investigating how connexin
regulation shapes intercellular communication in health and disease.

To tilt or not to tilt? Strategies for in situ cryo-EM data collection Recent breakthroughs in single-particle cryogenic electron microscopy (cryo-EM) and protein structure prediction have transformed our ability to resol…

Check out our recent review discussing the merits of tilt series vs single micrographs for in situ cryo-EM! www.sciencedirect.com/science/arti...

Magellon GUI for cryoEM

Exited to share my first PostDoc contribution! Like Magellan explored the globe, you can explore your cryoEM data with Magellon. Congrats to all involved. Scott Stagg Lab & Michael Cianfrocco Lab @landerlab.bsky.social www.biorxiv.org/content/10.1... 🌎❄️🔬

ChatGPT's Impact On Our Brains According to an MIT Study The study, from MIT Lab scholars, measured the brain activity of subjects writing SAT essays with and without ChatGPT.

time.com/7295195/ai-c...

spent some time this evening updating the teamtomo.org site - if you're interested in cryo-EM + Python you might want to take a look around!

And it’s done! Thanks to everyone who came out for the first edition of FrostByte, our event for the local computational cryo-EMers in the Bay Area ❄️

Special thanks to @joshdcryoem.bsky.social and Ariana Peck for help organizing 🙏