Jon Humphries

Method of the Year 2025: electron microscopy-based connectomics - Nature Methods A large network of interconnected neurons serves as the basis of brain function and of behavior. Methodological advances have enabled the reconstruction of large-scale and even whole-brain connectomes...

www.nature.com/articles/s41...

Calponin isoforms define the cell-type-specific organization and dynamics of actomyosin bundles Kokate et al. show that calponins regulate the architecture of actomyosin bundles. Their loss results in abnormal distribution of α-actinin, reduced thickness of actomyosin bundles, and impaired cell ...

Calponin isoforms define the cell-type-specific organization and dynamics of actomyosin bundles
www.cell.com/current-biol...

David Baltimore obituary: virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS The protein, reverse transcriptase, has become an essential tool for making DNA copies of RNA.

David Baltimore obituary: virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS
www.nature.com/articles/d41...

JOIN US at the inaugural Lab to Life melanoma conference!
ABSTRACT DEADLINE EXTENDED

ABSTRACT DEADLINE: Friday 19th December 2025
EARLY BIRD DEADLINE: FRIDAY 19th December 2025

Visit the conference website for more information and to view the exciting programme schedule
lnkd.in/en6iATNW

I'd expect this platform to flag a link to a variety of potential regulators.

‘They don’t have symptoms’: CAR-T therapies send autoimmune diseases into remission Engineered T cells that have been used to treat ulcerative colitis, rheumatoid arthritis and lupus show promising results.

‘They don’t have symptoms’: CAR-T therapies send autoimmune diseases into remission www.nature.com/articles/d41...

Doesn't IPA do this? Upstream regulators?

Cartoon of man sitting at a desk. Behind him is a sign saying "BLACK HOLE RESEARCH INSTITUTE". He is reading an item of correspondence. On the desk to the left there is a tray marked "IN". There is no tray marked "OUT".

😀

Welcome to my body After twenty years of pain and repeated medical dead ends, a stranger sent me a message on Instagram. It led to a diagnosis all the doctors…

Last month, I found out I have hypermobile Ehlers Danlos Syndrome, after decades of chronic pain and medical disinterest.

I've decided to write publicly about this, not just about hypermobility and its health impacts, but about how it feels when doctors don't care:

medium.com/p/4fea6398b8ba

Unlocking TIL Therapy: A New Era for Melanoma Care in the UK Join us for the Unlocking TIL Therapy: A New Era for Melanoma Care in the UK onsite at The Midland Hotel Manchester

Proudly delivered, label-free, in collaboration with @christieinstitute.bsky.social & The Christie Charity.

Limited places - please register early.
Looking forward to seeing many of you there! 🌟

🔗 Event link 👇

Every case study like this should be balanced by one such as a 15-year-old with suicidal ideation unable to receive any help because CAMHS has been cut to virtual non-existence.

Special Issue Imaging Cell Architecture and Dynamics Guest Editors: Francesca Bottanelli and Giulia Zanetti Deadline: 1 April 2026 Journal of Cell Science Call for papers logo Image of a cell

We invite you to submit your latest research to our upcoming special issue - Imaging Cell Architecture and Dynamics. This issue will be coordinated by two Guest Editors: @franbottanelli.bsky.social & Giulia Zanetti, with our Editor @guijacquemet.bsky.social. journals.biologists.com/jcs/pages/im...

A perfect model for coming together this season: mouse skeletal muscles undergoing fusion, obviously.

In this mesmerizing confocal microscopy video, nuclei are labeled in green & cell bodies are labeled in red. Credit: Yue Lu, Elizabeth Chen Lab, University of Texas Southwestern Medical Center

ERC success rates are tanking and the move is... even bigger grants for fewer people? smh

TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells
www.nature.com/articles/s41...

Breast cancer cell coculture induces normal lung fibroblast transition to CAFs, promoting tumor cell dormancy and therapy resistance
www.pnas.org/doi/10.1073/...

Talin–tensin3 interactions regulate fibrillar adhesion formation and tensin3 phase separation
rupress.org/jcb/article/...

Hemidesmosomes regulate epidermal differentiation during embryogenesis In skin epidermis, integrins mediate adhesion of basal keratinocytes to the underlying basement membrane. While high expression of integrins has been correlated with stemness, there is limited direct ...

Hemidesmosomes regulate epidermal differentiation during embryogenesis
www.biorxiv.org/content/10.1...

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration
www.sciencedirect.com/science/arti...

Integrin β4 Drives Immune Evasion and Therapeutic Resistance to PD-1 blockade in Bladder Cancer via MEK/ERK Signaling Bladder cancer (BLCA) is one of the most prevalent malignancies of the urinary system and accounts for 90-95% of urothelial carcinomas. Muscle-invasiv…

Integrin β4 Drives Immune Evasion and Therapeutic Resistance to PD-1 blockade in Bladder Cancer via MEK/ERK Signaling
www.sciencedirect.com/science/arti...

Capped high-force integrin bond lifetimes and spacing-tuned binding frequency drive rapid fibroblast migration | PNAS Cell migration relies on balancing focal adhesion (FA) stability—necessary for traction generation—and turnover—essential for forward translocation...

Capped high-force integrin bond lifetimes and spacing-tuned binding frequency drive rapid fibroblast migration
www.pnas.org/doi/10.1073/...

The integrin odyssey – a journey full of fundamental discoveries Summary: This Perspective highlights the key discoveries in integrin research that laid the foundation for a successful field.

The integrin odyssey – a journey full of fundamental discoveries
journals.biologists.com/jcs/article/...

In agreement with my friend @kkjetelina.bsky.social who writes today: "I suggest the general public avoid the CDC website."
yourlocalepidemiologist.substack.com/p/cdc-false-...

www.wsj.com/health/healt...

Systematic benchmarking of imaging spatial transcriptomics platforms in FFPE tissues - Nature Communications Wang, Huang, Nelson, Gao, and colleagues perform a head-to-head comparison of multiple platforms for imaging spatial transcriptomics, determining their relative sensitivity, specificity, and ability t...

www.nature.com/articles/s41...

Mechanobiology:
Microtubules provide a mechanical link for YAP/TAZ signalling
www.nature.com/articles/s41...

Excited to share our new preprint in @biorxiv-neursci.bsky.social

"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"

Instead of a 🧵 the paper is summarised in this video.

www.biorxiv.org/content/10.1...

Please repost - Multiple PhDs available

www.findaphd.com/phds/project...

www.findaphd.com/phds/project...

www.findaphd.com/phds/project...

The project is now live on FindaPhD and open for applications. Deadline December 4th

An exciting project to understand cellular ageing in health and disease.
Deadline for applications is 4th Dec.
www.findaphd.com/phds/project...

Pls see also our group websites:

TobiasZech: tzech6.wixsite.com/zechlab
• Chris Toseland: www.toseland-
lab.com