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Jon Humphries

@jdhl18.bsky.social

Cell Biologist. Manchester Metropolitan University. Cell-ECM adhesion and proteomics, often in the context of cancer. Google Scholar: https://scholar.google.com/citations?user=h9DWslsAAAAJ&hl=en Orcid: https://orcid.org/0000-0002-8953-7079

898 Followers  |  535 Following  |  540 Posts  |  Joined: 16.11.2024  |  2.0169

Latest posts by jdhl18.bsky.social on Bluesky


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Paxillin is our #CellLineOfTheWeek! ๐Ÿงซ

Our stem cell lines & plasmids are available for just the cost of shipping to lower the barriers to scientific discovery and breakthroughs.

๐Ÿš› Hosted and distributed by @coriellinstitute.bsky.social & @addgene.bsky.social

30.01.2026 17:11 โ€” ๐Ÿ‘ 6    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Well at least that fits with your experience. Thanks for sharing

13.02.2026 20:04 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Thought HeLa would be faster ๐Ÿคทโ€โ™‚๏ธ

13.02.2026 19:11 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Do you provide a stimulus to alter proliferation? Interested in the idea for our students too ๐Ÿ˜‰๐Ÿ‘Œ

13.02.2026 13:48 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

This looks really interesting from the Scott Holley lab. They do proteomics of itga5 complexes in zebrafish

13.02.2026 10:37 โ€” ๐Ÿ‘ 3    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Actn4 Links Inactive Integrin ฮฑ5 With Actin in Zebrafish Somites Integrins are key plasma membrane proteins that mediate cell-ECM adhesion and communication, and they rely on a conformational change for their activaโ€ฆ

Actn4 Links Inactive Integrin ฮฑ5 With Actin in Zebrafish Somites
www.sciencedirect.com/science/arti...

13.02.2026 10:17 โ€” ๐Ÿ‘ 3    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
FCHo2, not talin, enables inside-out activation of integrin ษ‘vฮฒ5 in curved adhesions - Nature Communications Talin has been believed to be indispensable for integrin activation. Here, the authors show that the curvature-sensing protein FCHo2, not talin, enables inside-out activation of integrin ษ‘vฮฒ5 in curve...

FCHo2, not talin, enables inside-out activation of integrin ษ‘vฮฒ5 in curved adhesions
www.nature.com/articles/s41...

12.02.2026 15:46 โ€” ๐Ÿ‘ 7    ๐Ÿ” 8    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Integrins ฮฑ3 and ฮฑ6 promote Th17 cell migration by activating the purinergic receptor P2X4 - Purinergic Signalling Interactions of effector T cells with laminins during their trafficking across basement membranes play a crucial role in the development of the adaptive immune response and inflammatory diseases. Howe...

Integrins ฮฑ3 and ฮฑ6 promote Th17 cell migration by activating the purinergic receptor P2X4
link.springer.com/article/10.1...

12.02.2026 15:44 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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The abstract submission deadline for our upcoming 'Imaging Cell Dynamics' meeting is this Friday. We still have a few places remaining so apply now to secure your spot!

Find out more at:
www.biologists.com/meetings/jcs...

#imaging #microscopy #cellbiology

11.02.2026 16:18 โ€” ๐Ÿ‘ 21    ๐Ÿ” 15    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 3
Webinar at EMBL's European Bioinformatics Institute (EMBL-EBI).Mapping biology in space: a guide to technologies and workflows in spatial transcriptomics.18 February 2026. 14:30 - 15:30 GMT. Valeriy Pak, EMBL Heidelberg.

Webinar at EMBL's European Bioinformatics Institute (EMBL-EBI).Mapping biology in space: a guide to technologies and workflows in spatial transcriptomics.18 February 2026. 14:30 - 15:30 GMT. Valeriy Pak, EMBL Heidelberg.

Join us next week for the first free webinar in our spatial transcriptomics series: www.ebi.ac.uk/training/eve...

Valeriy Pak, Predoctoral Fellow at @embl.org, presents 'Mapping biology in space: a guide to technologies and workflows in spatial transcriptomics' on 18 February | 14:30 UK time.

๐Ÿ–ฅ๏ธ๐Ÿงฌ

10.02.2026 13:23 โ€” ๐Ÿ‘ 6    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Excited to share our work on epithelial multilayering - identifying why stem cell stay in the basal layer and how and why differentiating cells move up. Great collab with @manningresearch.bsky.social and Niessen labs! Check out preprint and great summary below www.biorxiv.org/content/10.6...

10.02.2026 06:14 โ€” ๐Ÿ‘ 84    ๐Ÿ” 37    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 1
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UKRI increases minimum stipends for PhD students National funder commits to another above-inflation increase of almost 5 per cent

UKRI increases minimum stipends for PhD students share.google/4HamGmefmp2N...

09.02.2026 09:02 โ€” ๐Ÿ‘ 4    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Fantastic effort from everyone involved but especially Ernest and Sergey. @ernestiu.bsky.social

08.02.2026 14:48 โ€” ๐Ÿ‘ 3    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Fantastic news Ernest! well done

08.02.2026 14:48 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration Cell migration is crucial for development and tissue homeostasis, while its dysregulation leads to severe pathologies. Cell migration is driven by theโ€ฆ

My PhD work is finally out! Huge thanks to all the collaborators who made this possible ๐ŸŽ‰
Looking forward to the next chapter as a postdoc ๐Ÿ˜
www.sciencedirect.com/science/arti...

05.02.2026 16:54 โ€” ๐Ÿ‘ 7    ๐Ÿ” 2    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration Iu et al. uncover a Ca2+ signaling pathway promoting cell migration by facilitating actin assembly in protrusions. Ca2+ influx through TRPV4 channel activates RhoA in lamellipodia via CaMKII and TEM4,...

A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration: Current Biology www.cell.com/current-biol...

08.02.2026 14:45 โ€” ๐Ÿ‘ 11    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
Fill out our community survey to help shape the future of JCS

Journal of Cell Science logo

Line drawing of a group of people with speech bubbles above their heads

Fill out our community survey to help shape the future of JCS Journal of Cell Science logo Line drawing of a group of people with speech bubbles above their heads

After 15 years as Editor-in-chief (EiC), Michael Way @drmichaelway.bsky.social will be stepping down at the end of 2026 & we are seeking feedback from the cell biology community as part of the consultation process for appointing a new EiC.
We'd love to hear from you: www.surveymonkey.com/r/GZCC9F9

03.02.2026 13:36 โ€” ๐Ÿ‘ 23    ๐Ÿ” 26    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1

Leupaxin inhibits the durotaxis and mechanosensitivity of metastatic breast cancer cells https://www.biorxiv.org/content/10.64898/2026.02.03.703253v1

03.02.2026 21:30 โ€” ๐Ÿ‘ 0    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Unlocking TIL Therapy: A New Era for Melanoma Care in the UK TIL (Tumour-Infiltrating Lymphocyte) therapy is a transformative, cell-based immunotherapy approach now entering clinical practice for melanoma. This national summit brings together UK and internation...

๐Ÿ“ฃ Final agenda confirmed - only 5 weeks to go!

Join us on ๐Ÿญ๐Ÿญ ๐— ๐—ฎ๐—ฟ๐—ฐ๐—ต ๐Ÿฎ๐Ÿฌ๐Ÿฎ๐Ÿฒ in Manchester ๐Ÿ for our inaugural TIL Summit: Unlocking TIL Therapy โ€“ A New Era for Melanoma Care in the UK.

Kindly sponsored by The Christie Charity.

Space limited - so don't miss out! For further information & to register:

03.02.2026 14:49 โ€” ๐Ÿ‘ 5    ๐Ÿ” 4    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Our circadian clock and cancer chronotherapy, a terrific
@scripps.edu review, open-access, related to below!
jci.org/articles/vie...

03.02.2026 21:27 โ€” ๐Ÿ‘ 150    ๐Ÿ” 41    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1

Still time to register for this. Lots of fantastic talks lined up

03.02.2026 19:02 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Peoples Choice Awards | Liverpool City Region Combined Authority The People's Choice Awards is the ultimate fan-voted award show, honoring the best in movies, music, television, and more. Celebrate the fan favorites and vote now at the official People's Choice Awar...

Some blatant self promotion for my better half and an award nomination for her work at Alder Hey Children's Hospital.

The programme supports >11,000 children & young people in their care each year, through a range of creative patient led programmes.
www.liverpoolcityregion-ca.gov.uk/peoples-choi...

03.02.2026 18:52 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Mechanometabolism of cell adhesion: Vinculin regulates bioenergetics via RhoA-ROCK The focal adhesion protein vinculin affects the dynamics of the actin cytoskeleton, and reorganization of the actin cytoskeleton is an energetically demand

Mechanometabolism of cell adhesion: Vinculin regulates bioenergetics via RhoA-ROCK
rupress.org/jcb/article/...

02.02.2026 08:51 โ€” ๐Ÿ‘ 6    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Three UK research councils suspend funding opportunities Temporary blockย on grant applications by MRC, BBSRC and EPSRC heightens concerns over funding cuts

What's this about then?
www.timeshighereducation.com/news/three-u...

30.01.2026 22:52 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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International Developmental Mechanics Seminar Series Please fill out the following survey if you are interested in the 2025-2026 International Zoom Seminars on Developmental Mechanics.

๐ŸŽ‰ The Developmental Mechanics Seminar Series is back!
๐Ÿ—“๏ธ Thurs, Jan 22
๐ŸŽ™๏ธ Opening talks:
๐ŸงฌGuy Tanentzapf (UBC)
โ€” How cell adhesion molecules wire into the cytoskeleton
๐ŸŒ€Juan Manuel Gomez Elliff (EMBL)
@gomezjm-devmech.bsky.social
โ€” Mapping tissue mechanics with Brillouin microscopy

19.01.2026 11:13 โ€” ๐Ÿ‘ 11    ๐Ÿ” 8    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Establishing selectivity of FAK-paxillin PPI inhibitor using pulldown proteomics and a focal adhesion protein selectivity panel UA-2012 (and related non-myristoylated analog UA-1907) is a lead alpha-helical cyclic peptide which inhibits the focal adhesion kinase (FAK)-paxillin โ€ฆ

Establishing selectivity of FAK-paxillin PPI inhibitor using pulldown proteomics and a focal adhesion protein selectivity panel
www.sciencedirect.com/science/arti...

18.01.2026 08:27 โ€” ๐Ÿ‘ 1    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Laminin N-terminus ฮฑ31 regulates corneal epithelial cell adhesion and migration through modifying the organization and proteolytic processing of laminin 332 Laminin N-terminus ฮฑ31 (LaNt ฮฑ31) is a netrin-like protein generated by alternative splicing of the laminin ฮฑ3 gene. While previously shown to regulate vascular permeability in vivo, its role in epith...

Laminin N-terminus ฮฑ31 regulates corneal epithelial cell adhesion and migration through modifying the organization and proteolytic processing of laminin 332
journals.plos.org/plosone/arti...

18.01.2026 08:18 โ€” ๐Ÿ‘ 1    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Frontiers | A switch from ฮฑ5ฮฒ1 to ฮฑvฮฒ3 integrin activity contributes to the development of a profibrotic mesenchymal phenotype in trabecular meshwork cells Purpose: Fibrogenic changes in the trabecular meshwork (TM) are considered to be a major cause for the restriction in aqueous humor outflow from the anterior...

A switch from ฮฑ5ฮฒ1 to ฮฑvฮฒ3 integrin activity contributes to the development of a profibrotic mesenchymal phenotype in trabecular meshwork cells
www.frontiersin.org/journals/cel...

18.01.2026 08:05 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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CLDN5 as a novel modulator of podocyte adhesion to extracellular matrix via ฮฒ1-integrin binding The intricate glomerular filtration barrier relies on robust podocyte adhesion to the glomerular basement membrane (GBM), a process critical for kidneโ€ฆ

CLDN5 as a novel modulator of podocyte adhesion to extracellular matrix via ฮฒ1-integrin binding
www.sciencedirect.com/science/arti...

18.01.2026 08:01 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Deciphering KRAS inhibitor resistance - Nature Cell Biology Targeting oncogenic KRAS holds great promise but is often limited by rapid adaptive resistance. A study now shows that RASH3D19 is regulated by microRNAs and promotes resistance to RAS inhibition by e...

Deciphering KRAS inhibitor resistance
www.nature.com/articles/s41...

18.01.2026 07:56 โ€” ๐Ÿ‘ 1    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

@jdhl18 is following 20 prominent accounts