Felipe Muñoz-Guzmán

🎉🎖️Congratulations to 🌟Gabriel Péréz-Lara🌟 (UNAB, Santiago, Chile), winner of the FEBS Letters #PosterPrize at #MBioSys25, held in Puerto Varas, Chile! 🎉👏👏👏🎊

@molbiosystems.bsky.social

From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes Nature - A newly compiled atlas of species-wide structural variants and gene-based and graph pangenomes derived from highly complete assemblies of genomes from 1,086 natural isolates enable...

Incredible new paper from @schacherer.bsky.social et al rdcu.be/eLcTH

Participants of the 2025 SMBE Satellite Meeting on Molecular Mechanisms of Adaptation and Experimental Evolution

The SMBE Satellite Meeting in Puerto Varas, Chile, was a resounding success!

The meeting brought together >70 researchers from different continents for 3 days of inspiring science, vibrant discussion, and genuine community building.

Congratulations to the organization!

@smbe-chile2025.bsky.social

Meet the organizing committee, who has been hard at work to make the event happen:

Lorena Aguilar-Arnal🇲🇽
Paulo Canessa🇨🇱
‪Maria Ana Duhagon🇺🇾
@selfdz.bsky.social 🇦🇺
@lflarrondo.bsky.social 🇨🇱
@aemonten.bsky.social 🇺🇸
@pipemunozg.bsky.social 🇨🇱
@pstrobl.bsky.social 🇦🇷
Estefanía Tarifeño-Saldivia🇨🇱

Molecular Biosystems Conference Molecular Biosystems Conference

🚨 Registration for the Molecular Biosystems Conference is now OPEN! 🚨

Join us in southern Chile to discuss cutting-edge research in gene regulation & functional genomics.

📅 Sep 29-Oct 3, 2025
📍 Puerto Varas, Chile
🔗 Register here: molbiosystems.com

Secure your spot now—space is limited!

Happy to share this JOVE MS, we provide details on live-tracking maltose metabolism activation in yeast using LUC. We used our ❤️Patagonian Sacch. eubayanus to show how activitation proceeds under beer fermentation 🧐 🍺
@ibiochile.bsky.social @pipemunozg.bsky.social

app.jove.com/t/68161/in-viv…

Molecular Biosystems Conference Molecular Biosystems Conference

Had a 3-h long meeting yesterday with @pipemunozg.bsky.social to finalize some details for #mbiosys25!

We are almost there —registration opens soon! Follow @molbiosystems.bsky.social for details.

molbiosystems.com

Happy to present our latest pre-print: GRN_modeler - a user-friendly tool to model (synthetic) gene regulatory networks. We demonstrate its usefulness in designing new families of synthetic oscillators and build a light biosensor. Feedback welcome.
@dmf-unil.bsky.social @fbm-unil.bsky.social

Environmental microbiome, human fungal pathogens, and antimicrobial resistance Traditionally, antifungal resistance (AFR) has received much less attention compared with bacterial resistance to antibiotics. However, global changes, pandemics, and emerging new fungal infections have highlighted global health consequences of AFR. The recent report of the World Health Organisation (WHO) has identified fungal priority pathogens, and recognised AFR among the greatest global health threats. This is particularly important given the significant increase in fungal infections linked to climate change and pandemics. Environmental factors play critical roles in AFR and fungal infections, as many clinically relevant fungal pathogens and AFR originate from the environment (mainly soil). In addition, the environment serves as a potential rich source for the discovery of new antifungal agents, including mycoviruses and bacterial probiotics, which hold promise for effective therapies. In this article, we summarise the environmental pathways of AFR development and spread among high priority fungal pathogens, and propose potential mechanisms of AFR development and spread. We identify a research priority list to address key knowledge gaps in our understanding of environmental AFR. Further, we propose an integrated roadmap for predictive risk management of AFR that is critical for effective surveillance and forecasting of public health outcomes under current and future climatic conditions.

www.cell.com/trends/micro...

Book cover of "Your Inner Fish" by Neil Shubin, featuring an artistic representation of a prehistoric fish-like creature with skeletal elements exposed. The subtitle highlights the discovery of a 375-million-year-old ancestor.

I misheard this as “You’re In a Fish”, which sounds decidedly more fun.

A phylogenetic approach to comparative genomics - Nature Reviews Genetics Controlling for phylogeny is essential in comparative genomics studies, because species, genomes and genes are not independent data points within statistical tests. The authors review the application ...

Comparative genomics needs to use phylogenetic methods: why, how and common questions www.nature.com/articles/s41... @annadewar.bsky.social @lauriebelch.bsky.social

Fact checking is not censorship.

It's an essential public service.

Disinformation kills. Period.

Environment‐Organism Feedbacks Drive Changes in Ecological Interactions Ecological interactions are central to our understanding of the composition and function of communities, but attempts to use them as a theoretical foundation for experimental ecology have been confou....

Our framework explaining why ecological interactions change between contexts is out in Ecology Letters!
A lovely collaboration with @saramitri.bsky.social which provides experimentally-testable links between the physiology and ecology of microbes.
onlinelibrary.wiley.com/doi/10.1111/...

Incredibly excited to share that our manuscript was just published in @nature.com ! What a way to start the new year! 🎉
https://buff.ly/4gyYCzx

We present phylowave, a framework that enables to learn the fitness dynamics of pathogens from phylogenies.

🧵 A thread... 1/n
#IDSky #IDModelling

Excited to report that Joy Bergelson (bergelsonlab.org) and I will be running a brand new GRC conference on the Function of Evolving Systems in the summer of 2026. The 2028 one will be chaired by Mikhail Tikhonov (physics.wustl.edu/people/mikha...) and @asanchezlab.bsky.social! Stay tuned!

The post doc who moved to the industry

Synthetic Origins Michael Elowitz on the early years of synthetic biology and the programmability of living cells.

Interesting interview with Michael
Elowitz on some of his early work on synthetic biology.

Also like his discussion of how the “cell as computer” metaphor can both illuminate and mislead.

🐋🌱🦫🦋🧪 #HistSTM #Evobio #Livingmatter

Nematode-Trapping Fungus Arthrobotrys oligospora is Hungry for COQ7 to Alleviate Environmentally Triggered Iron Overload https://www.biorxiv.org/content/10.1101/2024.12.24.630212v1

End-of-year read! The work of Melvin Bérard in the @sophiemartinlab.bsky.social is now out in @plosbiology.org.

Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast

doi.org/10.1371/jour...

GRETA graphical abstract

We present Gene Regulatory nETwork Analsyis (GRETA), a framework to infer, compare and evaluate gene regulatory networks #GRNs. With it, we have benchmarked multimodal and unimodal GRN inference methods. Check the results here 👇
Paper: doi.org/10.1101/2024.12.20.629764
Code: github.com/saezlab/greta

Out today! 🚨 We explore how planetary oxidation ~2.5 billion years ago shaped the puzzling history of metal use in nitrogenase, key to nitrogen fixation! 🌍🔬

www.biorxiv.org/content/10.1...

Congrats, @msobol.bsky.social! #earlylife #paleobiology #evolution

The Impact of Selected Lachancea Yeast Strains on the Production Process, Chemical Composition and Aroma Profiles of Beers

Full text: pubmed.ncbi.nlm.nih.gov/39683832/

Reminder about our Methods Collection with JoVE on “ Current Methods in Bone Biology and Regeneration ”
app.jove.com/fr/methods-c...

Big discounts on publications fees for ECR!

Abstract submission link: app.jove.com/fr/methods-c...

In other words: no, you can't "easily tell when someone has used an LLM"; and if you think you can enforce a ban with detectors, you're doing damage.

Niche breadth specialization impacts ecological and evolutionary adaptation following environmental change Abstract. Ecological theory predicts that organismal distribution and abundance depend on the ability to adapt to environmental change. It also predicts th

Excited to share our new study in @ismepublications.bsky.social showing that microbial niche breadth specialisation (being a generalist or a specialist) impacts ecological and evolutionary adaptation following environmental change doi.org/10.1093/isme...

RETRACTED: Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/locate/withdrawalpolicy).Concerns have bee…

If you did not know: finally, hytdroxychloroquine is not an effective treatment against COVID. 😀

"Having followed due process (...) the co-owners of the journal (Elsevier and ISAC) have therefore taken the decision to retract the article."

www.sciencedirect.com/science/arti...

The Plant Cell | Oxford Academic The Plant Cell publishes novel research of special significance in plant biology, especially in the areas of cellular biology, molecular biology, biochemistry, genetics, development, and evolution.

We are proud to announce @theplantcell.bsky.social as a sponsor for #mbiosys25!

Since 1989, the journal -published by @aspbofficial.bsky.social - has been at the forefront of plant science research, publishing groundbreaking work on gene regulation, genomics, and more.

⬇️Learn more

Oligonucleotide-based CRISPR-Cas9 toolbox for efficient engineering of Komagataella phaffii A streamlined CRISPR-Cas9-based toolbox that improves the engineering process of Komagataella phaffii yeast by implementing short single-stranded DNA seque

My first post in 🦋🟦-> Our plasmids from #Pichia tools paper doi.org/10.1093/fems... are now available @addgene.bsky.social 🤓

Three must read papers for PhD students. #scisky #PhD #science #research #academicsky

1. The importance of stupidity in scientific research

Open Access
journals.biologists.com/jcs/article/...

Unlocking the potential of experimental evolution to study drug resistance in pathogenic fungi - npj Antimicrobials and Resistance npj Antimicrobials and Resistance - Unlocking the potential of experimental evolution to study drug resistance in pathogenic fungi

Unlocking the potential of experimental evolution to study drug resistance in pathogenic fungi

-in NPJ antimicrobials and resistance from @hanscarolus.bsky.social
with Patrick van Dijck lab

www.nature.com/articles/s44...