Tristan Rodriguez

New blog post. In which I analyze the new HHMI announcement and what it means for the science publishing ecosystem openrxiv.org/preprint-man...

Pathway to Independence: a forecast for the future of developmental biology ABSTRACT. In 2022, Development launched its Pathway to Independence (PI) programme, aimed at supporting postdocs as they transition to their first independent position. In 2025, we welcome our third c...

Meet the 2025 cohort of @dev-journal.bsky.social Pathway to Independence fellows

Read about the scientific visions of eight dev bio post-docs entering the academic job market

journals.biologists.com/dev/article/...

🪰 Calling all Drosophilists interested in nutrition…HolFast, Sebastian Sorge’s new chemically defined diet works really well. We’ve given some free HolFast aliquots to @vdrc-flies.bsky.social Please contact them directly if you fancy trying it out. Hurry while stocks last!

Pathway to Independence – an interview with Joaquín Navajas Acedo.

In this interview, @mads100tist.bsky.social talks about about his research vision, zebrafish and the importance of community:

journals.biologists.com/dev/article/...

1/n Dear friends, in light of the current events in Palestine and to help spread awareness, a large number of filmmakers have made their FILMS about PALESTINE AVAILABLE FOR ONLINE FOR FREE

Below, we are sharing links to films that you can watch and share to spread our message to the world:

Thrilled to share our work using live imaging to understand how Epiblast (future embryo proper) and Primitive Endoderm (future extraembryonic tissues) cell fates segregate in the preimplantation mouse embryo. Gargantuan effort led by amazing @rpkimyip.bsky.social, David Denberg and Denis Faerberg!

We wrote this introductory review on how concepts from dynamical systems can help us understand developmental biology, hope it’s useful to somebody! It was a lot of fun to put together, and great to collaborate with brilliant colleagues across theory and experiments

Boundary constraints can determine pattern emergence The robust patterning of cell fates during embryonic development requires precise coordination of signalling gradients within defined spatial constraints. Using a geometrically confined in vitro syste...

New work with Saunders & Charras labs

Physical boundaries guide cell fate decisions during human trunk development

Reaction Diffusion model shows how geometry shapes biology with TBXT expression forming consistent domains regardless of colony size & shape

www.biorxiv.org/content/10.1...

Next time, consider submitting to Biology Open. Decision with reviews within 7 working days of submission journals.biologists.com/bio/pages/fa...

Brexit has never looked quite so daft

The Company of Biologists 100 logo to the left and QR code to the right. Portrait of Daniel Gorelick to the left, text to the right 100 extraordinary biologists Daniel Gorelick Daniel Gorelick is the current Editor-in-Chief of Biology Open, aiming to improve author experience by providing fair and timely decisions on manuscripts. Dan is Associate Professor and Zebrafish Core Director at Baylor College of Medicine, USA, investigating endocrine-disrupting chemicals’ influence on embryonic development. #100biologists #biologists100

Our next extraordinary biologist this week is Daniel Gorelick, current Editor-in-Chief of @biologyopen.bsky.social and Associate Professor at @bcmhouston.bsky.social, USA. To know more about Dan’s visions for BiO, read this Editorial: doi.org/10.1242/bio.....
#100biologists

We pay our academic editors (we don't do special issues with guest editors). Beginning in April, we also pay peer reviewers @biologyopen.bsky.social details to be announced at #biologists100 bit.ly/4h1cmCC @biologists.bsky.social

EpiSci - Hi there! Our review “Mechanotransduction in stem cells” is finally published. With @carstenschulte4.bsky.social we provided a comprehensive picture, that aims to cover the whole mechanotransductive pathway from the cell microenvironment to the nucleus. 1/3 pubmed.ncbi.nlm.nih.gov/38729084/

And I'm very embarrassed not to have acknowledged this earlier. The project was led by Shruthi Krishnan and couldn't have happened without the invaluable collaboration of the Vousden lab.

I very thoughtful and reflective piece.

A postdoctoral position is available in my lab to study the subcellular organisation of signalling of the glucagon receptor family. For more information and to apply please click here: www.imperial.ac.uk/jobs/search-...

An excellent opportunity to go to a great lab with a caring mentor.

This could constitute a novel tissue sparing mechanism that would minimise cell elimination in cases of maternal malnutrition or low protein diets. However, this protection would be at the expense of optimal tissue function, as it would allow the persistence of dysfunctional cells in the tissue.

As the key feature of loser cells is mitochondrial dysfunction, these results suggest that cell competition is eliminating these cells when amino acids are plentiful but sparing them in protein poor
environments.

The most interesting finding from the paper is that loser cell elimination can be prevented by decreasing the levels of extra-cellular L-proline.

Thank you James 😊

As always, perfect choice. Thank you Sally ☺️

Thank you Aida 🫠

Thank you 🙂

Thank you 😊

Thank you Alex!

Origin, fate and function of extraembryonic tissues during mammalian development - Nature Reviews Molecular Cell Biology During mammalian embryogenesis, extraembryonic tissues are required for the patterning and morphogenesis of the embryo. This Review discusses how signalling networks and epigenetic modifications regul...

Nice to see our latest review published in
@natrevmcb.bsky.social today – a collaborative exploration of mammalian extraembryonic development with @cwhanna.bsky.social for an invaluable epigenetic focus. @srinivas-lab.bsky.social

www.nature.com/articles/s41...

Sensing of extracellular L-Proline availability by the integrated stress response determines the outcome of cell competition Cell competition is a quality control acting from development to the adult that eliminates cells that are less-fit than their neighbours. How winner cells induce the elimination of losers during this ...

Very happy to share the latest preprint from the lab. We find that during cell competition, winners induce an increase in proline metabolism in loser cells, and this drives their elimination through repression of the integrated stress response.
biorxiv.org/cgi/content/...

Essential reading for all is that serve as reviewers. Please help your authors as if they were in your lab. Make your reviews constructive.

Overly onerous reviews amount to blocking each others’ work. It slows progress and demoralizes junior investigators.

Let’s elevate, not crush, #DevBio