Francisco Falcon

Grateful and excited to launch the Otsuki Regeneration Group at the Hubrecht Institute!
🔗 www.hubrecht.eu/research-gro...

We study how tissues regenerate - and use those principles to build 3D tissues in vitro.

Full announcement: www.linkedin.com/in/leo-otsuk...

@hubrechtinstitute.bsky.social

25.07.2025 07:30 — 👍 70    🔁 12    💬 12    📌 2

Exactly two weeks left to submit your abstract to the EMBO Mobile Genome Workshop.
☝️this year we will select from abstracts 2 “long” talks to highlight last minute breakthrough from early career scientists. Apply! July 29th

15.07.2025 12:35 — 👍 16    🔁 13    💬 1    📌 0

Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

09.07.2025 10:04 — 👍 292    🔁 127    💬 15    📌 10

REFEREE 1: “I conclude with a simple, direct statement - this is the best paper I have read all year!”
#TransparentPeerReview

Co-evolving infectivity and expression patterns drive the diversification of endogenous retroviruses
@juliusbrennecke.bsky.social et al

www.embopress.org/doi/full/10....

06.06.2025 14:18 — 👍 102    🔁 33    💬 3    📌 2

Delighted that our work on positional memory is now published. We asked how axolotl cells 'know' which part of the limb to regenerate after injury.
www.nature.com/articles/s41...
A joy to work with super team Sarah Plattner, Yuka Sugiura, Francisco Falcon and Elly Tanaka.
🧵1/14

21.05.2025 15:05 — 👍 211    🔁 67    💬 23    📌 9

Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇

17.03.2025 11:56 — 👍 545    🔁 259    💬 11    📌 33

My first post in bsky and my first pre-print as well. Hope you enjoy this brief highlight made by @alexdemendoza.bsky.social and team!

15.01.2025 14:35 — 👍 3    🔁 1    💬 1    📌 0