Adrian Mulholland

Arctic rivers deliver less vital nitrogen as climate change alters water chemistry Climate change is starving the Arctic Ocean of essential nutrients, with the region's six largest rivers now delivering far less of the type of nitrogen that marine ecosystems need to survive, accordi...

Warming temperatures and thawing permafrost are fundamentally altering the chemistry of Arctic rivers

…cutting off vital nitrogen supply, threatening entire marine food webs that support Indigenous communities

phys.org/news/2025-08...

Donald Trump to fire US labour statistics boss after weak jobs report President says he will replace Bureau of Labor Statistics head with ‘someone much more competent and qualified’

Ah yes the tried & tested method when you don’t like numbers - fire the person who showed them to you. on.ft.com/4mIALAf Donald Trump to fire US labour statistics boss after weak jobs report

Great to have hosted Matilda and Rada for their research visits to Bristol @bristoluni.bsky.social Well done both. Au revoir!

Covid measures pushed down deaths from influenza to remarkably low levels. The death rate is surging back--including 266 children. 90% of children who died in the 2024-2025 flu season were not fully vaccinated against the flu. www.cdc.gov/fluview/surv...

Record marine heat waves in 2023 covered 96% of oceans, lasted four times longer than average Heat waves aren't just getting worse on land, the majority of the world's oceans are experiencing record-breaking temperatures too. These marine heat waves are getting longer, more intense and reachin...

Record marine heat waves in 2023 covered 96% of oceans, lasted four times longer than average

phys.org/news/2025-07...

Record marine heatwaves may signal a permanent shift in the oceans Fierce marine heatwaves were recorded globally in 2023 and 2024, and some researchers now believe they mark the start of a fundamental change with devastating consequences for life on Earth

🌊 Record marine heatwaves may signal a permanent shift in the oceans

www.newscientist.com/article/2489...

Amid Fear of Retaliation, N.S.F. Workers Sign Letter of Dissent

"In the letter, the signatories warned that National Science Foundation grants now underwent a 'covert and ideologically driven secondary review process'...”

www.nytimes.com/2025/07/22/s...

Thanks to the organizers @dougpires.bsky.social @gonzaparra.bsky.social who even arranged for Liverpool to be sunny (sometimes!)

Great to speak in excellent #3DSIG meeting at #ISMBECCB2025 on physics-based simulations in the Age of AlphaFold

Dynamic Behavior and Substrate Interactions of the Polymyxin Resistance Determinant MCR-1 Investigated by Molecular Dynamics Simulations in the Membrane Environment The Mobile Colistin Resistance (MCR) phosphoethanolamine (PEtN) transferase is a plasmid-borne enzyme responsible for colistin antibiotic resistance in Escherichia coli, the most important antimicrobi...

🎉 Our preprint “Dynamic Behavior ... of the Polymyxin Resistance Determinant MCR-1 ... in the Membrane Environment” in colab with @adrianmulholla1.bsky.social @marcvanderkamp.bsky.social is now published in JCIM.
📖 Read it here: pubs.acs.org/doi/10.1021/...

Yup. "Let's be utterly dependent on a set of volatile, largely foreign-origin commodities" strikes most as stupid.

No, AlphaFold has not completely solved protein folding Biology is hard. Yes, even for AI.

AlphaFold is great, but contrary to public opinion it has not completely solved the protein folding problem. Much work remains to be done.
clauswilke.substack.com/p/no-alphafo...

As the latest UK heatwave starts, it's very warm (5-6°C above normal) across the most of the country.

Watch how things change hour-by-hour: istheukhotrightnow.com

Website by @roostweather.bsky.social.

🚨 Check out the updated version of our latest preprint with @adrianmulholla1.bsky.social, @marcvanderkamp.bsky.social, and many others!
📄 Read it here 👉https://chemrxiv.org/engage/chemrxiv/article-details/685d6114c1cb1ecda080add6

Stanford to reduce budget by $140 million, lay off employees for next academic year The University shared its plan for a $140 million reduction in the allocation of funds in a letter to faculty and staff.

$140M BUDGET CUT and LAYOFFS coming to Stanford in September (not counting the medical school) to prepare for deep cuts to federal funding. "...the University will prioritize preserving research funding, particularly for PhDs, and undergraduate financial aid."

St Paul’s Carnival, among other things

"WE'VE ARRANGED A society based on science and technology, in which nobody understands anything about science technology. And this combustible mixture of ignorance and power, sooner or later, is going to blow up in our faces. Who is running the science and technology in a democracy if the people don't know anything about it?" "Science is more than a body of knowledge, it's a way of thinking. A way of skeptically interrogating the universe with a fine understanding of human fallibility. If we are not able to ask skeptical questions, to interrogate those who tell us that something is true, to be skeptical of those in authority, then we're up for grabs for the next charlatan, political or religious, who comes ambling along."

I think a lot about what Carl Sagan said in one of his final interviews.

Trump’s Betrayal of Ukraine Bridget Brink, the former ambassador to Ukraine, on that country’s war with Russia, America’s betrayal of Ukraine, and why she resigned

“What’s at risk now is so much bigger than just Ukraine.”

On “The David Frum Show,” Bridget Brink, the former ambassador to Ukraine, discusses Ukraine’s war with Russia, America’s role, and why she resigned:

Very noticeable that none of the big Brexit backing accounts on X have said anything at all about the 9th anniversary of the chaos they unleashed.

Almost like they'd rather we all forgot about it.

Four images to illustrate some prominent single-gene myths. Top left shows a photograph of a person deftly rolling their tongue into a U-shape. Top right shows a photograph of a person’s ear, highlighting the shape and features of the earlobe and cartilage. Bottom left shows a close-up photograph of a person’s eye, with a vivid blue colouration. Bottom right shows a photograph of a person poised to write with their left hand on the blank white page of a spiral-bound notebook.

Remember when you first learned about genetics at school? All those fascinating examples of human traits that are each apparently determined by just a single gene? Time to check in on some of your favourites to see how they’re doing. 🧬🧵🧪 1/n

I suspect that fact that the vast majority of LLM users don’t seem to have received this (really very simple!) message is because the AI companies have a vested interest in us not understanding it. “ChatGPT is smart, it just makes mistakes sometimes” is much more marketable than the truth.

Major US climate website likely to be shut down after almost all staff fired Exclusive: Climate.gov, which supports public education on climate science, will soon no longer publish new content

Climate.gov, a major US government website supporting public education on climate science, will likely shut down after almost all of its staff were fired. What would be worse is if the website were co-opted to publish climate denial content.

📣💻[JOB OFFER] I am looking for a postdoc with experience in QM/MM, MD and biosystems, and who would be motivated to study the formation mechanisms of oxydative histone modifications. Please share! #compchem #histones #PTM #redox #DNA
emploi.cnrs.fr/Offres/CDD/U...

Ousted CDC vaccine adviser says RFK Jr.'s message is clear: ‘Scientific expertise is no longer of use’ Terminated CDC vaccine adviser Helen Chu spoke with STAT about her fears for the future of vaccine policy

Helen Chu is one of the ousted #ACIP members. She spoke to me today about her grave concerns for future vaccination policy and vaccine access in the United States. www.statnews.com/2025/06/10/c...

Very sorry to read that. “All the best”. Good grief.

RFK Jr. Removes All CDC Vaccine Panel Experts (Gift Article) The U.S. health secretary chose to “retire” members of a committee that makes significant decisions about who receives immunizations, including the vaccines for children.

“This is an unmitigated public health disaster,” said Dr. Sean O’Leary, chair of the infectious disease committee for the American Academy of Pediatrics. Story by @apoorvanyt.bsky.social Gift link: nyti.ms/4mV37YK

We just had an article published in ACS Central Science on the how the pH of exhaled aerosol evolves over time.

As we’ve previously reported, respiratory aerosol pH (high pH!) is a driver of SARS-CoV-2 decay. Meaning, understanding the pH dynamics is important for estimating risk.

Do you remember the Human Genome Project? I’m not sure the Trump administration wants you to The NIH archives of the Human Genome Project could fall victim to Trump administration cuts, writes a former archivist.

The NIH archives of the Human Genome Project could fall victim to Trump administration cuts, writes a former archivist. buff.ly/H1WkRpn