Sakari Vanharanta

New issue of Annual Reviews of Cancer Biology is out!
www.annualreviews.org/content/jour...

Finland is the happiest country in the world for the eighth year in a row For the eighth year in a row, Finland ranked in the top spot on the World's Happiness Report's annual ranking of the happiest countries in the world.

www.cnbc.com/2025/03/19/w...

Very interesting work on the role of germline genetics in somatic tumor evolution.

Last few days to apply👇! In addition to hot science, our campus offers refreshing dips within walking distance 💪🏖️ #BalticSea #Helsinki

Looking for a PhD? Follow this🧵 to know how Adaptmet's innovative training will combine continuous training in cutting-edge metastasis research with custom-made network-wide events to enhance, accelerate & elevate the skills, capacities & network of our doctoral candidates (DCs)

Engineered extrachromosomal oncogene amplifications promote tumorigenesis - Nature Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene a...

🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...

Super cool work, congrats Andrea and the team!

CRISPR-StAR enables high-resolution genetic screening in complex in vivo models - Nature Biotechnology Pooled genetic CRISPR screening is improved in complex models through leveraging internal controls.

Today we published a new paradigm to do CRISPR screens in complex model systems such as in vivo but also e.g. in organoids. The publication came out in Nature Biotechnology.
1/
www.nature.com/articles/s41...

Inherited Gene Variant Tied to Breast Cancer Spread A common germline variant of PCSK9 significantly increases the risk of breast cancer metastasis, a new study has revealed. The finding—a first example of inherited genes driving metastatic progression...

aacrjournals.org/cdnews/news/...

Come join us!

Very interesting insight into tumor-immune interaction under chemotherapy in ovarian cancer. Congrats Anniina, Anna and the teams!

Congrats Direna, fantastic news!

Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis - Nature Studies using mouse models of lung adenocarcinoma identify an association between age, iron homeostasis and tumour initiation potential that involves NUPR1 and lipocalin-2.

New in @natureportfolio.bsky.social from the Tuomas Tammela Lab: how aging suppresses tumorigenesis and stemness in the lung by promoting functional iron insufficiency in the alveolar epithelium. Interestingly, this renders aged cells resistant to ferroptosis. #OncSky www.nature.com/articles/s41...

Come join us and @svanharanta.bsky.social @cedric-blanpain.bsky.social Roger Gomis @irbbarcelona.bsky.social @obenaufa.bsky.social Karin de Visser @nkinl.bsky.social @grauperalab.bsky.social @prat-aleix-md.bsky.social @vickysanzmoreno.bsky.social @johannajoyce.bsky.social @momobentires.bsky.social

Congrats Anais and @guillemxtivill.bsky.social, you've done such a fantastic job with this!

Inflammatory monocytes can restimulate T cells in tumors, and cancer cell-induced disruption of this process can lead to tumor immune evasion. Details 👇 in the wonderful 🧵 by @obenaufa.bsky.social and the paper published today @Nature. What a privilege it has been to be part of this amazing team!

Maybe me too? Thanks so much!

Hello Bluesky, we are recruiting PhD students in cancer and metastasis biology! This is a fantastic program that brings together several leading European research institutes. Details here: adaptmet.eu/recruitment/