Infant CD4 T-cell response to SARS-CoV-2 mRNA vaccination is restricted in cytokine production and modified by vaccine manufacturer AbstractBackground. Safe and effective vaccines are a key preventative measure to protect infants from SARS-CoV-2 infection and disease. Although mRNA vacc

Regarding mRNA vaccines in infants, little is known about the quality of CD4 T-cell responses, which are pertinent in coordinating immune responses during infection, induced by vaccination. #PITT_IDFall25

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This article discusses the risk of contracting viral infections following allogeneic hematopoietic cell transplantation (alloHCT). #PITT_IDFall25

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Another Canadian baby dies from measles as South Carolina reports outbreak In other developments, South Carolina suspects community transmission in an outbreak in the Upstate region.

Community transmission of measles occurred recently in South Carolina, and all cases occurred in unvaccinated individuals who do not have immunity from previous infections. #PITT_IDFall25

www.cidrap.umn.edu/measles/anot...

Severity of Clinical Presentation and Outcomes in Hospitalized Adult Patients with Influenza by Type and Subtype, United States—2017–2020 Adults hospitalized with influenza A(H1N1) virus infection had a higher risk of ICU admission compared to those with influenza A(H3N2) and a higher risk se

Here’s an article that discusses the differences in clinical presentation and hospitalization outcomes among the different influenza types and subtypes. #PITT_IDFall25

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Early versus deferred antiretroviral therapy initiation and long-term cardiovascular disease outcomes in people with HIV: The START study While it is known that HIV increases cardiovascular disease (CVD) risk in people with immunodeficiency, we did not find evidence that delaying treatment in

Interesting article about early versus deferred antiretroviral treatment initiation for HIV and long-term cardiovascular disease. #PITT_ID2025

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Hyalomma lusitanicum

Hyalomma lusitanicum, a tick endemic to the Iberian Peninsula, is a vector and reservoir for the emerging Crimean-Congo hemorrhagic fever virus (CCHFV), which leads to a severe and fatal infectious disease. #PITT_IDFall2025

www.sciencedirect.com/science/arti...

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Annual Variant-Targeted Vaccination to Prevent Severe COVID-19 in Cohorts With Vaccine-Derived and Hybrid Immunity Among US Veterans with hybrid immunity for COVID-19, annual variant-targeted booster vaccination yielded modest but significant gains in protection against

Interesting article about the effectiveness of annual variant-targeted vaccination against severe COVID-19 illness in individuals with hybrid and vaccine-derived immunity. #PITT_ID25

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Senegal rolls out “six-in-one” jab, making life easier for families and health workers The hexavalent vaccine – introduced into Senegal’s routine vaccination schedule in July – protects kids against six diseases with a single shot. That means fewer injections for babies, fewer clinic vi...

In July, Senegal introduced a hexavalent vaccine, which includes tetanus, diphtheria, whooping cough, polio, hepatitis B, and Haemophilus influenzae type B. #PITT_ID25

www.gavi.org/vaccineswork...

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Body Mass Index and Incident Tuberculosis in Close Tuberculosis Contacts BMI <25 kg/m², a readily available biomarker, identified IGRA-positive close contacts at high risk for progression to TB in a large observational Brazil

Interesting article about the relationship between body mass index (BMI) and the progression to tuberculosis (TB) disease in people infected with M. tuberculosis. #PITT_ID25

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Development of a comprehensive program for the early diagnosis and treatment of severe infections in a tertiary hospital in Spain AbstractObjectives. To assess the impact of the Rapid Diagnosis and Treatment of Severe Infections (rDTSI) program on diagnostic and clinical outcomes in p

The Rapid Diagnosis and Treatment of Severe Infections (rDTSI), a program developed for the diagnosis and treatment of hospital infections, found a decrease in the median time to pathogen-directed therapy in pneumonia and a decrease in hospital stays. #PITT_ID25

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Cefepime-Taniborbactam—a Novel Combination Therapy for Multidrug-Resistant Pathogens This article describes the properties of cefepime-taniborbactam, a novel combination therapy in development for multidrug-resistant gram-negative pathogens

Cefepime-Taniborbactam, which is in advanced clinical development, has promising use against multidrug-resistant (MDR) gram-negative pathogens. #PITT_ID25

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HIV Superinfection in Kidney Transplant Recipients With HIV Who Received Organs From Donors With HIV Transplantation of kidneys from donors with HIV to recipients with HIV is increasing. Among 18 recipients, there was one confirmed case of donor-derived HI

Interesting article about HIV superinfection in kidney transplant recipients with HIV receiving kidneys from HIV-positive donors. #PITT_ID25

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The spatiotemporal ecology of Oropouche virus across Latin America: a multidisciplinary, laboratory-based, modelling study Our data suggest that climatic factors are major drivers of OROV spread and were potentially exacerbated during 2024 by extreme weather events. OROV glycoprotein reassortants, but not individual OROV ...

Oropouche virus, a virus that causes mild to moderate symptoms (but has been fatal in pregnant women) and can be spread by mosquitoes, has become more widespread in Latin America. #PITT_ID25

www.thelancet.com/journals/lan...

Nirmatrelvir–ritonavir versus placebo–ritonavir in individuals with long COVID in the USA (PAX LC): a double-blind, randomised, placebo-controlled, phase 2, decentralised trial Nirmatrelvir–ritonavir administered for 15 days did not significantly improve health outcomes in participants with long COVID compared with placebo–ritonavir at day 28. However, the study showed the f...

In a randomized control trial, it was found that there was no significant difference in health outcomes of participants with long COVID who received either nirmatrelvir-ritonavir (Paxlovid) for 15 days or placebo-ritonavir for 28 days. #PITT_ID25

www.thelancet.com/journals/lan...

Use of dog serologic data for improved understanding of coccidioidomycosis: A One Health approach Analysis of anti-Coccidioides serologic test results for nearly 900,000 U.S dogs (2012-2022) provided new insights into epidemiology of coccidioidomycosis

Interesting article about the use of dog serologic data to predict the risk of coccidioidomycosis (Valley fever) infection in humans. #PITT_ID25

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Community-Embedded Low-Barrier Care: a model for engaging people with complex needs in HIV treatment and prevention Abstract. People living homeless and people with substance use disorders are at increased risk for HIV but experience multiple intersecting barriers to acc

People experiencing homelessness and substance use disorder have an increased risk of contracting HIV, but they also experience more barriers to accessing the healthcare services that they need. #PITT_ID25

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Virus that killed Betsy Arakawa, wife of Gene Hackman, kills 3 in Mammoth Officials confirmed three hantavirus deaths in Mammoth Lakes this year, prompting public health concerns.

Hantavirus, which is contracted by humans from infected deer mice and causes Hantavirus Pulmonary Syndrome (HPS), has caused the deaths of three people in California in the first few months of 2025, raising alarm among public health experts. #PITT_ID25

www.sfgate.com/renotahoe/ar...

Facts and myths about measles It seems ironic that Robert F Kennedy Jr, one of the most prominent antivaccine activists, has been made Secretary of Health and Human Services in the USA while one of the largest recent measles outbr...

Interesting article about measles and the misinformation spreading about the vaccine. #PITT_ID25

www.thelancet.com/journals/lan...

Pandemic Social Distancing and Declines in Nasopharyngeal Carriage of Pneumococcus and Related-Antimicrobial Resistant Genes: Evidence from Household-Based Cohort Studies in Lima, Peru In prospective household-based cohort studies in Lima, Peru, we assessed the prevalence of pneumococcal carriage and related antibiotic resistance genes ju

Interesting article about the reduction in the nasopharyngeal carriage of S. pneumoniae in individuals in communities in Lima, Peru with stricter social distancing policies. #PITT_ID25

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Impact of Multicohort Human Papillomavirus Vaccination on Cervical Cancer in Women Below 30 Years of Age: Lessons Learned From the Scandinavian Countries Recently, cervical cancer incidences have decreased markedly in young women in the Scandinavian countries. The decrease in Denmark and Sweden was seen many

HPV vaccination is super important in the prevention of cervical cancer in young women! #PITT_ID25

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Withdrawal of the United States from the WHO — How President Trump Is Weakening Public Health | NEJM Severing the long-standing ties and scientific collaborations between the United States and the WHO and slashing U.S. financial support will have catastrophic effects on both domestic and global he...

Here’s an article from the New England Journal of Medicine about how the withdrawal of the US from the WHO is negatively impacting public health, which could lead to future epidemics and pandemics. #PITT_ID25

www.nejm.org/doi/full/10....

Measles Cases and Outbreaks Find the latest numbers of confirmed U.S. measles cases. CDC updates this page weekly

So far in 2025, there have been 341 confirmed measles cases, while in 2024 there were 198 confirmed measles cases. #PITT_ID25

www.cdc.gov/measles/data...