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Helen Chen

@hc327.bsky.social

#iPSC scientist & #organoids engineer for #RareDisease working on disease modeling & precision medicine. @StJudeResearch, @ubc alumnusπŸ‡¨πŸ‡¦

115 Followers  |  170 Following  |  2 Posts  |  Joined: 04.12.2024  |  1.3364

Latest posts by hc327.bsky.social on Bluesky

Excited to share my latest paper from @stjuderesearch.bsky.social , where we leverage patient derived cortical organoids to study UBA5 associated neurodevelopmental disorders.

07.05.2025 19:26 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Its FINALLY here! The first #FluorescenceFriday πŸ§ͺπŸ”¬out of the Hall lab! We're still in the process of optimizing different fixatives to look for cytonemes and cellular extensions, but a fantastic first time imaging them from Morgan Hiebert!

04.04.2025 21:49 β€” πŸ‘ 25    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
NIH3T3 cells with a long cytoneme contacting one of the cells to deliver a signal. The SHH ligand is in magenta, the SHH transport protein DISP is in red. Nuclei are blue. Green is the adhesion protein BOC.

NIH3T3 cells with a long cytoneme contacting one of the cells to deliver a signal. The SHH ligand is in magenta, the SHH transport protein DISP is in red. Nuclei are blue. Green is the adhesion protein BOC.

Despite all that is going on, I will not miss a #FluorescenceFriday! ✊ This is a confocal micrograph of a long cytoneme making contact with a recipient NIH3T3 cell (right) to deliver SHH ligand. The 🟣 dots are packages of SHH. Very cool! πŸ”¬ by former postdoc @erichall.bsky.social. πŸ§ͺ #SciArt #DevBio

21.02.2025 16:12 β€” πŸ‘ 58    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0
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Here is an early #FluorescenceFriday post - a 3D render of a developing mouse neural tube showing a signaling filopodium (cytoneme) reaching toward a primary cilium (green) to deliver a cellular signal (SHH, magenta). See alt text for details. Research supported by #NIH #NIGMS πŸ”¬ by Eric Hall. πŸ§ͺ

23.01.2025 20:12 β€” πŸ‘ 63    πŸ” 8    πŸ’¬ 0    πŸ“Œ 0
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MSc or PhD Student Positions: Cytoneme mediated cell-cell communication in development and disease at Hall Lab

πŸ§ͺπŸ§‘β€πŸ”¬ We are actively recruiting graduate students in the lab right now at UM!
If you are, or know a student looking to do cool research involving cell signaling, development, and πŸ”¬, please share with your networks. For more information, checkout the link below.
rfhs.myjboard.io/jobs/1054626...

21.01.2025 18:34 β€” πŸ‘ 7    πŸ” 9    πŸ’¬ 0    πŸ“Œ 1

Great lab! Great opportunity! Highly recommend!

22.01.2025 00:19 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Lead Researcher / Scientist - Mefford Lab in Memphis, Tennessee | St. Jude Careers St. Jude Careers is hiring a Lead Researcher / Scientist - Mefford Lab in Memphis, Tennessee. Review all of the job details and apply today!

The Mefford Lab is #hiring, come join us! @hcmefford.bsky.social

We have TWO positions open:

(1) *Lead Researcher/Scientist* who will have the opportunity to lead 2D and 3D #epilepsy #genetics modeling to inform better targeted treatments for kids. πŸ§ πŸ§¬πŸ’œ

talent.stjude.org/careers/jobs...

04.12.2024 16:18 β€” πŸ‘ 8    πŸ” 7    πŸ’¬ 1    πŸ“Œ 1

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