Moritz Bauer

Great PhD opportunity with a fantastic mentor!

Congrats Mada! So well deserved and can’t wait to see what will come out of your lab!

MeCP2 binding and genome–lamina reorganization precede long gene activation during mouse corticogenesis During corticogenesis, neural gene expression is tightly coordinated by chromatin and epigenetic changes, whose misregulation can lead to neurodevelopmental disorders[1][1]–[4][2]. The role of spatial...

1/ 🧵 I am excited to share a new preprint from our group:
Single-cell Dam&T-seq during mouse corticogenesis reveals how genome–lamina interactions regulate long neuronal genes.
doi.org/10.1101/2025...
#Neurodevelopment #Epigenetics @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social

The PRC2-associated factor EPOP is required for Hox gene regulation during axial development in mice The Polycomb repressive complex 2 (PRC2) is an essential modulator of gene repression. We previously reported that, in mouse embryonic stem cells, PRC…

Finally out on @devbiol.bsky.social‬: we find that Epop mutant mice have near-perfect Polycomb phenotype (orderly posterior shift of vertebral identity🩻) linked to accelerated HOX clock⏰.

Bonus: Epop has maternal effect!

Study co-led by the the labs of Bernie Payer and @lucianodicroce.bsky.social

Congrats Ivano, Anna et al.! Happy to see this out with so many familiar faces :)

Great use of DamID to use it as a history tracing tool!

Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation - Nature Cell Biology Kefalopoulou, Rullens et al. develop Dam&ChIC to assay chromatin state at two different time points in the same cell. The method was used to study the reorganization of LADs during cell division a...

I am very excited to share our latest work where we describe a new method to profile genome-wide chromatin transitions over time in single cells. Great collaborative effort with the van Oudenaarden group @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social www.nature.com/articles/s41....

Great new paper from the lab highlighting the utility of multimodal single-cell readouts!

🧬 Looking for a PhD position in molecular or developmental biology? 🔬

✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/

🧬Postdoc position alert! 🚨 We're hiring a postoc in Computational Modeling of Epigenetic Inheritance at the Hubrecht Institute (Alexander van Oudenaarden, Utrecht 🇳🇱) & Danish Cancer Institute (Anja Groth, Copenhagen 🇩🇰).

Come work in our collaberative team of top scientists

shorturl.at/avBBy

Identifying cross-lineage dependencies of cell-type-specific regulators in mouse gastruloids Braccioli et al. use time-resolved single-cell chromatin accessibility analysis to study mouse gastruloid development. They identify key transcription factors driving mesoderm and spinal cord differen...

🚨 Paper Alert 🚨
I'm incredibly proud and excited to announce that our latest research on the chromatin regulatory profile of gastruloids has been published in @DevCell! 🎉

Check out the full paper here:
www.cell.com/developmenta...

@dewitlab.bsky.social , @bracciolilab.bsky.social 🙌

🧵👇

Congrats Luca! Great story and so happy to see it out now!

Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...

PREPRINT! Park et al. makes the case that we may be misunderstanding heterochromatin for past 30 years due to ChIP-Seq biases... 1/n

International Dutch Embryo Model Meeting 2025 | Radboud University Join us for the International Dutch Embryo Model Meeting 2025 in Nijmegen, NL! This two-day event will feature experts presenting cutting-edge research on blastoids, gastruloids, and iPS-gametes, incl...

www.ru.nl/en/about-us/...

A hitchhiker's guide to single‐cell epigenomics: Methods and applications for cancer research Genetic mutations are well known to influence tumorigenesis, tumor progression, treatment response and relapse, but the role of epigenetic variation in cancer progression is still largely unexplored....

A new review from our group on the implementation of single-cell epigenomics in cancer research. A hitchhiker's guide for the use of both wet- & drylab methods. A big shout-out to Marta and Isabel! doi.org/10.1002/ijc....

📢 Save the date! We are excited to announce the International Dutch Embryo Model Meeting 2025 in Nijmegen (NL) on Thursday 27 March and Friday 28 March! Registration is open now. More information: ru.nl/en/about-us/...

Big thanks to Hendrik Marks for taking the lead this time!

I am really happy to announce the first Hubrecht Symposium on March 13th 2025! We will organize these yearly events on a specific topic in molecular and developmental biology to emphasize the importance of fundamental research for Dutch science. Free of charge! www.hubrecht.eu/hubrecht-sym...

Very excited to see our work on genome-wide mapping DNA repair in single cells out @naturecomms.bsky.social
Amazing work by Kim de Luca & Pim Rullens. Wonderful collaboration with the Legube lab, @mariekeoudelaar.bsky.social & @jjachowicz.bsky.social . rdcu.be/d0ZAM