Victor Dubach

Ready to TANGO? 💃 In our new publication, Beata Turoňová & Markus Schreiber (@ms314.bsky.social, @becklab.bsky.social) present TANGO: the first cryoET framework to analyze the relation between particle positions and orientations 🪩 All in a single user-friendly package! #CryoET #OpenScience

Enjoying long incubation times and snowy days in Frankfurt ☃️

LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery.
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.

🔗 doi.org/10.64898/202...

#CryoET

We resolved the molecular architecture of a condensate—inside cells. 🤯 By combining in situ cryoET with multiscale simulations, we show how a single point mutation modifies molecular interactions, shifts the condensate’s material properties, and alters its biological function. Preprint 👇

It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...

Yesterday I finally defended my PhD thesis - time to say thank you to all those who were part of this journey as mentors, collaborators, colleagues and friends!

Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...

Exciting week in Frankfurt! Our CEOS energy filter and ASI Timepix3 are installed and we're looking forward to running the first tests :) #CryoEM #timepix #REELanalysis #4DSTEM @mpibp.bsky.social

Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO

Structure of the ribosome-bound SND3 translocon complex from the heat-tolerant fungus Chaetomium thermophilum. The SND3 translocon inserts proteins into the endoplasmic reticulum membrane as they are produced by the ribosome.

SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.

Bonnie Murphy and Ralf Steinhilper stand together, smiling at the camera. Ralf is wearing a creatively handcrafted doctor’s hat.

Heartfelt congratulations to @ralfsteinhilper.bsky.social @bjmurphylab.bsky.social on successfully defending his PhD thesis with summa cum laude! 👏💪🏆 For his doctoral research, Ralf used anaerobic sample preparation to study redox enzymes by single-particle cryo-EM.🔬 #phdlife #biophysics #excellence

Big thanks to everyone at @bjmurphylab.bsky.social and @mpibp.bsky.social for your support and for making this such an unforgettable time!

Group of people looking at camera with a nature green background.

Our yearly retreat brought together our PhD students 👩‍🔬from Frankfurt and Mainz for a journey of science and community building in the mountains of Switzerland! 🏔️ #gradschool #imprs_cbp
Photos: Vinay Singh

cryoTIGER: deep-learning based tilt interpolation generator for enhanced reconstruction in cryo electron tomography - Communications Biology Deep learning-based interpolation using cryoTIGER enhances angular sampling in cryoET, improving 3D reconstructions, particle localization, and structural recovery without increasing electron dose.

❓What if you could peek between your tilt series ❓ We are proud to introduce cryoTIGER -- deep-learning based tilt interpolation for enhanced reconstruction in cryo-ET. A great collaboration between Turoňová lab, @becklab.bsky.social, @hummerlab.bsky.social #teamtomo www.nature.com/articles/s42...

Photo of Sergio Cruz and text: Sergio Cruz-León receives the 2026 Theory & Computation Postdoctoral Research Award

🎉 Congratulations to our postdoc @sergiocruzleon.bsky.social for receiving the 2026 Theory & Computation Postdoctoral Research Award from the Biophysical Society! 🎉 Sergio will present his work at the Theory & Computation subgroup Symposium during the 2026 Biophysical Society meeting.

Visualizing the Main Gate into Mitochondria

🔬 Check out our new article on the mitochondrial TOM complex! Researchers from the Structural Biology Department have resolved a high-resolution structure of the main entry point for proteins into mitochondria. 🚪 🤩
Read more: www.biophys.mpg.de/2876415/tom-main-gate-into-mitochondria?c=2011019

Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...

SND3 is the membrane insertase within a fungal multipass translocon https://www.biorxiv.org/content/10.1101/2025.07.08.663624v1

🎉We’re celebrating the #SCALE-it-Best-PhD-Awards-2025, honoring exceptional researchers! 🎓 This year, three remarkable dissertations were recognized, selected from a highly competitive and multidisciplinary pool of candidates. 🧵

Looking for a tool to measure membrane thicknesses in tomograms (#TeamTomo)? Or curious about thickness differences within and across organelles? Check out my fellow @becklab.bsky.social PhD student @deglushk.bsky.social's excellent preprint:
www.biorxiv.org/content/10.1...

New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇

Get yourself a supervisor with whom you can laugh!
…So this happened two days ago… Incredibly grateful for all the fun and support over the years with @bjmurphylab.bsky.social and all the great people at @mpibp.bsky.social 🎓

Happy International Women and Girls in STEM Day! Every mentor and act makes a difference - when we support a girl's curiosity or champion a female colleague, we inspire the next generation and one another. Let’s make STEM a place where all women & girls can thrive 🔬👩🏼‍🔬#WomenInSTEM

In case you wondered what it looks like "in real life" when the FluScreen of a Krios cryoEM is retracted/inserted: here you go. ❄️🔬

Exciting green news! 🦠 Do you know how certain microorganisms make a living by transforming CO2 into useful molecules? Check out our new work on the molecular choreography behind acetyl-CoA synthesis in the CODH/ACS protein complex. 👩‍🔬 🔗 www.biophys.mpg.de/2844976/micr...

Congrats, Max! And big thanks and congratulations to our coauthors at MPI for Marine Microbiology, Bremen, MPI-CBG in Dresden, and in-house at the MPI of Biophysics! It's been great working with you all! @mpimarinemicrobio.bsky.social, @mpicbg.bsky.social sky.social, @hummerlab.bsky.social

Cryo-EM structure of the NDH–PSI–LHCI supercomplex from Spinacia oleracea - Nature Structural & Molecular Biology Here, the authors report the structure of the nicotinamide adenine dinucleotide phosphate dehydrogenase–photosystem I–light-harvesting complex I supercomplex, providing insights into subunit interacti...

I am very happy to share our latest work on the detailed cryo-EM structure of the NDH-PSI supercomplex of spinach. Thanks to Werner Kühlbrandt, Alex Hahn and @mpibp.bsky.social ! 🍃❄️🔬
You can find the paper in open access in Nature Structural and Molecular Biology:
www.nature.com/articles/s41...

Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy - Nature Cell Biology Licheva, Pflaum, Babic, Mancilla et al. show that low-affinity cargo–receptor interactions promote autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub ...

Check out our latest publication in @naturecellbiology.bsky.social on the role of phase separation in selective autophagy initiation! This was done in a fantastic collaboration with
‪@kraftlabfr.bsky.social‬

www.nature.com/articles/s41...

Short teaser below 👇👇👇

Two-stage binding of mitochondrial ferredoxin-2 to the core iron-sulfur cluster assembly complex - Nature Communications De novo [2Fe-2S] cluster synthesis by the mitochondrial ISC complex requires electrons from ferredoxin-2 (FDX2). The authors map FDX2 binding to the core ISC complex, showing that FDX2 can bind in two...

Hello bluesky, we’re excited to be here! To start off, we want to share our latest work on the FDX2-bound core ISC complex, which is now published in Nature Comms.

Congrats to @ralfsteinhilper.bsky.social and everyone else involved! 🎉

www.nature.com/articles/s41...

Congratulations Bis!!🎉