MatteviLab

Congratulations to everyone but especially Venda & Sylvie for this nice work and thanks to Andrea Murachelli in my lab for his analyses

Preparations in full swing. Exciting program, looking forward to msandm2025.org and welcome our guests in Utrecht to discuss mass spectrometry, atomic force & electron microscopy and single molecule techniques

Great Science, great people and great time and the EMBO Workshop "When predictions meet experiments: next challenges in structural biology" - Palermo, 9-12 September 2025.
More will come :)
#EMBOStructuralBio

Jeroen Mesters remembers Rolf Hilgenfeld (1954-2025) doi.org/10.1107/S205...

Great work!

AI-Enhanced Adaptive Virtual Screening Platform Enabling Exploration of 69 Billion Molecules Discovers Structurally Validated FSP1 Inhibitors Identifying potent lead molecules for specific targets remains a major bottleneck in drug discovery. As structural information about proteins becomes increasingly available, ultra-large virtual screen...

Just out with @gorgulla.bsky.social, StJude and Haribabu Arthanari, Harvard. AdaptiveFlow screens ultra large libraries of 70 billion compounds. We discover #coenzymeQ inhibitors of #ferroptosis suppressor protein #FSP1 validated experimentally with crystal structures
www.biorxiv.org/content/10.1...

Unlocking the secrets to enzymes, the catalysts of life How do enzymes come together, how do they interact and how do they coordinate their functions? To find the answers, the EU-funded MetaQ...

Delighted to see our ERC project featured on CORDIS_EU as the project of the month. We are keen on understanding the architecture of metabolism: Unlocking the secrets to enzymes, the catalysts of life | News | CORDIS | European Commission cordis.europa.eu/article/id/4...

Rolf Peter Hilgenfeld (1954–2025) Rolf Hilgenfeld lived a life in the fast lane, devoted entirely to science, in which he absorbed a wealth of knowledge, conscientiously created new knowledge and passionately passed it on to his stude...

Jeroen R. Mesters: Rolf Peter Hilgenfeld (1954–2025)
doi.org/10.1107/S205... #IUCr

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Cells often organize enzymes into dynamic clusters, or metabolons.
These aren’t rigid complexes—but can they really boost reaction efficiency? We explored this question in the context of Coenzyme Q (CoQ) biosynthesis.

Complete Enzyme Clustering Enhances Coenzyme Q Biosynthesis via Substrate Channeling Metabolons - transient assemblies of sequential metabolic enzymes - facilitate the reactions of multi-step metabolic pathways, yet, how they mechanistically bolster metabolic flux remains unknown. Her...

Excited to share our new preprint on “Complete Enzyme Clustering Enhances Coenzyme Q Biosynthesis via Substrate Channeling”
A collaboration between @ShakhnovichLab and @MatteviLab
Read on bioRxiv: www.biorxiv.org/content/10.1...

Multitasking Proteins: Exploring Noncanonical Functions of Proteins during Mitosis This review provides a comprehensive overview of how mitotic cells drive the repurposing of proteins to fulfill mitosis-specific functions. To ensure the successful completion of cell division, the cell strategically reallocates its “workforce” by assigning additional functions to available proteins. Protein repurposing occurs at multiple levels of cellular organization and involves diverse mechanisms. At the protein level, proteins may gain mitosis-specific functions through post-translational modifications. At the structural level, proteins that typically maintain cellular architecture in interphase are co-opted to participate in mitotic spindle formation, chromosome condensation, and kinetochore assembly. Furthermore, the dynamic reorganization of the nuclear envelope and other organelles relies on the temporary reassignment of enzymes, structural proteins, and motor proteins to facilitate these changes. These adaptive mechanisms underscore the remarkable versatility of the cellular proteome in responding to the stringent requirements of mitosis. By leveraging the existing proteome for dual or multiple specialized roles, cells optimize resource usage while maintaining the precision needed to preserve genomic integrity and ensure the survival of the next generation of cells.

Super excited to share my latest review!
In this piece, I dive into how cells cleverly reuse proteins for mitosis-specific tasks — a fascinating and still underexplored area.
There’s so much more to uncover, and I hope this review sparks new ideas and discussions!
pubs.acs.org/doi/10.1021/...

George M. Sheldrick (1942–2025) In memory of George Sheldrick.

A tribute to George Sheldrick and SHELX and the impact on macromolecular and small-molecule crystallography

journals.iucr.org/a/issues/202...

Always on the Move: Overview on Chromatin Dynamics within Nuclear Processes Our genome is organized into chromatin, a dynamic and modular structure made of nucleosomes. Chromatin organization controls access to the DNA sequence, playing a fundamental role in cell identity and...

Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....

In collaboration with @mattevilab.bsky.social, we share in @naturecomms.bsky.social our work studying the mechanism of LSD1 covalent ‘formylators’. Many LSD1 inhibitors create a bulky FAD-drug adduct. Discovered by Takeda by phenotypic screening, these formylators serendipitously create formyl-FAD.

Jan Drenth (1925–2025) Jan Drenth is remembered.

Bauke W. Dijkstra et al.: Jan Drenth (1925–2025) @univgroningen...#IUCr https://journals.iucr.org/paper?S205979832500275X

Design of Benzyl-triazolopyrimidine-Based NADPH Oxidase Inhibitors Leads to the Discovery of a Potent Dual Covalent NOX2/MAOB Inhibitor NADPH oxidases (NOXs) are enzymes dedicated to reactive oxygen species (ROS) production and are implicated in cancer, neuroinflammation, and neurodegenerative diseases. VAS2870 is a covalent inhibitor...

Interested in shutting down two powerful enzymatic sources of ROS? Check out our latest work in J Med Chem on dual NOX2/MAOB covalent inhibitors. In microglia models, it reduces ROS production and proinflammatory cytokines. #ROS #oxidativestress
pubs.acs.org/doi/full/10....

Calling everyone interested in learning biocatalysis! Come to the Narayan lab to learn the biocat basics. Please apply here - docs.google.com/forms/d/e/1F...

#Biocat #GoBlue

A black-and-white photo shows a woman in a patterned dress with a lace collar and pearl necklace, sitting in a chair. The background features shelves with bottles and a wire basket, suggesting an early 20th-century setting, possibly a pharmacy or study.

On this day in 1879, Maud Menten was born in Port Lambton, Ontario.
In her work as a medical researcher, she became a leading expert in histochemistry and enzyme kinetics while fighting against sexism in her field.
Let's learn more about her life!

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When predictions meet experiments: the next challenges in structural biology Building on the success of the 2022 EMBO Workshop “When Predictions Meet Experiments: The Future of Structure Determination”, this second edition continues the journey at the interface of computation…

Register now for EMBO Workshop "When predictions meet experiments: The next challenges in structural biology" in Palermo, Italy, 9 – 12 September 2025

Abstract submission & registration deadline: 1 July

meetings.embo.org/event/25-str...
#EMBOStructuralBio #EMBOevents 🧪

Redefining the Limits of Functional Continuity in the Early Evolution of P-Loop NTPases Abstract. At the heart of many nucleoside triphosphatases is a conserved phosphate-binding sequence motif. A current model of early enzyme evolution propos

Our latest paper, "Redefining the Limits of Functional Continuity in the Early Evolution of P-Loop NTPases", now out as an Advance Article on Mol. Biol. Evol. Join us as we explore the potential origins of the earliest protein folds! With Liam Longo, among others. academic.oup.com/mbe/advance-...

Excited to share our latest work with the fraaije.bsky.social (Groningen U) & Ram (Leiden U) groups on sorbicillinoid natural products in ACS Chem Bio! CRISPR-powered expression in A. niger boosts protein yields, and crystal structures reveal key catalytic mechanisms. pubs.acs.org/doi/10.1021/...

Sine Ydun Larsen (1943–2025) Sine Larsen, former President and former General Secretary and Treasurer of the IUCr, is remembered.

Lidin et al.: Sine Ydun Larsen (1943–2025) @lundsuni...#IUCr https://journals.iucr.org/paper?S2053273325001019

Jan was very warm and welcoming when I was a post-doc in Groningen at the same time. His humanity was evident in the way he held no grudges for the time he spent doing forced labour in Germany during WW2.

Wonderful work and so happy of being part of it

The lecture room is really packed for this @thermofishersci.bsky.social #cryoem roadshow in Pavia today!

I am really happy to share our study about the 4-allylsyringol #oxidase from S. cavernae. It turned out to be a very interesting #flavoenzyme with high biocatalytic potential for 2,6-substituted phenols.

Congratulations Francesca!! Andrea

We are on bluesky! Our wonderful group.