Jüri Reimand

made my first meme to celebrate the never-boring pathway to publication. #PIlyfe #openaccess

Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis - Nature Biomedical Engineering Fluid shear stress plays a role in medulloblastoma metastasis through a PIEZO2-actomyosin-GLUT1 signalling cascade.

Excited to see this study led by Nick Min & Xi Huang published this week and grateful for a decade of collaborations : www.nature.com/articles/s41...

The PACIFIC method is available on github: github.com/reimandlab/P...

Congrats to our PhD student Masroor Bayati for his first-author publication out this week. We developed a computational method to map synergistic interactions in omics datasets and studied prognostic signals of co-occurring cancer driver alterations and TME features. aacrjournals.org/mcr/article/...

Scientists no Longer Find Twitter Professionally Useful, and have Switched to Bluesky Synopsis. Social media has become widely used by the scientific community for a variety of professional uses, including networking and public outreach. For

Hey everybody! @drjuliawester.bsky.social and I have a new paper!

We surveyed over 800 scientists, science communicators, and science educators who use social media.

Conclusion: Scientists no longer find Twitter useful or pleasant, and many have switched to Bluesky! 🧪🌎🦑

doi.org/10.1093/icb/...

A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function - Nature Biotechnology RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.

A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function go.nature.com/4mc1SmQ

GitHub - reimandlab/ActivePathways: Integrative pathway enrichment analysis of multivariate omics data Integrative pathway enrichment analysis of multivariate omics data - reimandlab/ActivePathways

We released a new version of ActivePathways for directional integration of multiomics datasets. V2.0.6 includes methods to compare directional & non-directional analyses to find candidate genes & pathways lost or gained when directionality is accounted for: github.com/reimandlab/A... led by @mslob95

www.nature.com/articles/s41...

meticulously delve into intricate this

Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma through an innate immune process Radiation, the most effective treatment for medulloblastoma, induces an innate immune response and opens the blood-brain barrier, allowing for the intravasation of tumor cells into the blood circulati...

Another great collaboration with Carolina Nor & Michael Taylor: Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma through an innate immune process. @abahcheli.bsky.social led our omics integration via pathway analyses. @cp-devcell.bsky.social www.cell.com/developmenta...

Transparent peer review to be extended to all of Nature’s research papers From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.

From today, every paper submitted to Nature -if published - will be accompanied by peer reviewers comments & authors rebuttal.

We started the trial in 2020; we now want to open up the review process & showcase its role in shaping & improving papers
🧪 #AcademicSky

www.nature.com/articles/d41...

Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain - Nature Neuroscience In Alzheimer’s disease (AD), disruptions in myelin and axonal structures occur, although the underlying mechanisms remain unclear. Here the authors show that, at the myelin–axon interface, axon–glial ...

Very happy to have contributed to this comprehensive study on myelin–axon interface vulnerability in Alzheimer’s disease by @yifeicai.bsky.social @jgrutzendler.bsky.social. @mslob95 led our integrative pathway analyses. All started from a brief posterside chat at CSHL www.nature.com/articles/s41...

very happy to have contributed to this collaboration with the Taylor lab - with integrative pathway analyses & rich network visualizations led by our PhD student @abahcheli.bsky.social

“Recruiting U.S. scientists is a fine idea – except we’re barely supporting Canadian scientists as it is”

https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/4FRDBEKLNFESVJ3ZILAS36KR7Y

George R. R. Martin on @biorxiv-evobio.bsky.social!

Assessment of a Polygenic Risk Score in Screening for Prostate Cancer | NEJM The incidence of prostate cancer is increasing. Screening with an assay of prostate-specific antigen (PSA) has a high rate for false positive results. Genomewide association studies have identified...

Assessment of a Polygenic Risk Score in Screening for Prostate Cancer - using a spit test www.nejm.org/doi/full/10....

The end of the genetic paradigm of cancer Genome sequencing results and single-cell transcriptomics continue to produce findings that challenge the idea that cancer is purely a ‘genetic disease’. This Essay delves into cancer omics data that ...

enjoyed this thought-provoking essay: The end of the genetic paradigm of cancer
journals.plos.org/plosbiology/...

Mid-Career to Senior Principal Investigator About OICR   OICR is Ontario’s cancer research institute. We bring together people from across the province and around the world to improve the lives of everyone affected by cancer. We take on the big...

We are recruiting a Principal Investigator in Computational Biology at @oicr.on.ca: oicr.bamboohr.com/careers/378. This position is in downtown Toronto, adjacent to the University of Toronto where your university appointment would be. Please contact me if you have any questions!

Thanks for the list! I’d like to join too