James Wright

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Delighted to announce that Marcus Bokkerink will be delivering the ILPC Annual Lecture 2025.

This will launch the ILPC Annual Conference 2025 -

Regulating AI in a Changing World: Oversight & Enforcement

Registration and more details available soon.

We hope you can join us!

LDNQImmuno · April 10th A community day for researchers in the quantitative life sciences from across London.

Come join us for the 3rd LDN Quantitative Immunology Day on 10th of April @ucl.ac.uk ! All info and free registration 👉 qimmuno.com/ldnday/

Detection of human unannotated microproteins by mass spectrometry-based proteomics: a community assessment https://www.biorxiv.org/content/10.1101/2025.02.19.639069v1

I am really looking forward to the 'Hidden Cell, Dark Genome’ conference in Edinburgh this week. I will be presenting our work on non-canonical cancer proteins. #proteomics #darkgenome @uoe-igc.bsky.social @icr.ac.uk

Sign up now for the 'Enter the Dark Genome - Instructions Hidden in Plain Sight' talk by @katarney.bsky.social at @rcpedin.bsky.social on 2 April from 6-7pm, followed by a drinks reception: edin.ac/4ip4egz

Arrived at @fogenomics.bsky.social London and firstly, they have a full size X wing on the floor. Pretty bloody cool, now off to the proteomics stage.

I'm the last speaker so if you stay until the end, do pop by and if you saw this on Bluesky you have the right to ask a horrible question at the end

I enjoyed presenting our research on non-canonical cancer peptides discovery at #fog2025 #festivalofgenomics today

One to watch.

What a huge legal precedent the US Supreme Court could set here for policymakers/courts everywhere.

Upholding a law that requires the selling of a big tech platform that gather data of citizens from other countries, which may then share that data with their intelligence agencies.

Scientific Officer - Epigenetics and Genome Stability in Chelsea | The Institute of Cancer Research View details and apply for this Scientific Officer - Epigenetics and Genome Stability vacancy in Chelsea . Salary : Commencement on the salary range is subject to comparable skills and exp...

We are looking for someone to join our lab as a researcher (scientific officer). Advert and information on applying is here: jobs.icr.ac.uk/vacancies/10...
It's a great team and a wonderful place to work!

Open-source and FAIR Research Software for Proteomics Scientific discovery relies on innovative software as much as experimental methods, especially in proteomics, where computational tools are essential for mass spectrometer setup, data analysis, and in...

Recently, We saw a discussion on the role of open-source in proteomics. Here, experienced developers & researchers maintaining OS tools for years shared this comment to guide newcomers in the field about OS and its role in the field. 💻 #Proteomics #OpenSource chemrxiv.org/engage/chemr...

ProHap - Search your proteomics data against population variants! Critically important new community resource! STOP. IGNORE THE FLOWCHART ABOVE. These are bioinformatics people, they think this stuff is mandatory. I assume their conferences all have...

This new resource is AMAZING. You can easily search (re-search) your proteomics data in the context of human genomics (you know, that whole thing where we don't all have the exact same genome?) Read the paper, but instructions in the blog post - proteomicsnews.blogspot.com/2024/12/proh...

An AI companion suggested he kill his parents. Now his mom is suing. A new Texas lawsuit against Character.ai, alleging its chatbots poisoned a son against his family, is part of a push to increase oversight of AI companions.

"When he said that his parents limited his screen time, another bot suggested 'they didn’t deserve to have kids.' Still others goaded him to fight his parents’ rules, with one suggesting that murder could be an acceptable response." www.washingtonpost.com/technology/2...

TERMINALLY ILL ADULTS (END OF LIFE) BILL SECOND READING

AYES: 330
NOES: 275

Maj: 55

It passes- with a significant majority. Huge but somber moment in the chamber, the first time the Commons has voted for assisted dying. But there’s a long parliamentary passage to go.

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

YouTube video by Magnus Palmblad The Great Search Engine Race

The Great Search Engine Race (cumulative citations in Europe PMC over time): youtu.be/7l5gAFOm6VE?...

‘Dark proteome’ survey reveals thousands of new human genes Database confirms that overlooked segments of the genome code for a multitude of tiny proteins

Do you want to go further with your proteomics? Looking for something new in cancer?

Check out microproteins!

Thanks to @science.org for featuring this work, in collaboration with @sebastiaanvheesch.bsky.social, #HUPO, @gencodegenes.bsky.social

www.science.org/content/arti...

🔎 microprotein
🧬 💻

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️

So how can we ever achieve #gender #equality?

We discuss various strategies in this #Cell Commentary

#WomeninSTEM

www.cell.com/cell/fulltex...
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PhoXplex: Combining Phospho-enrichable Cross-Linking with Isobaric Labeling for Quantitative Proteome-Wide Mapping of Protein Interfaces Integrating cross-linking mass spectrometry (XL-MS) into structural biology workflows provides valuable information about the spatial arrangement of amino acid stretches, which can guide elucidation of protein assembly architecture. Additionally, the combination of XL-MS with peptide quantitation techniques is a powerful approach to delineate protein interface dynamics across diverse conditions. While XL-MS is increasingly effective with isolated proteins or small complexes, its application to whole-cell samples poses technical challenges related to analysis depth and throughput. The use of enrichable cross-linkers has greatly improved the detectability of protein interfaces in a proteome-wide scale, facilitating global protein–protein interaction mapping. Therefore, bringing together enrichable cross-linking and multiplexed peptide quantification is an appealing approach to enable comparative characterization of structural attributes of proteins and protein interactions. Here, we combined phospho-enrichable cross-linking with TMT labeling to develop a streamline workflow (PhoXplex) for the detection of differential structural features across a panel of cell lines in a global scale. We achieved deep coverage with quantification of over 9000 cross-links and long loop-links in total including potentially novel interactions. Overlaying AlphaFold predictions and disorder protein annotations enables exploration of the quantitative cross-linking data set, to reveal possible associations between mutations and protein structures. Lastly, we discuss current shortcomings and perspectives for deep whole-cell profiling of protein interfaces at large-scale.

PhoXplex: Combining Phospho-enrichable Cross-Linking with Isobaric Labeling for Quantitative Proteome-Wide Mapping of Protein Interfaces

#proteomics #massspec #tmt #xl-ms #proteininteraction

pubs.acs.org/doi/10.1021/...

I took biochem in 2001, and for nearly 20 years read amino acid sequences daily… and I never knew Dayhoff named them or even the logic behind things like Q until last Friday (h/t Mike Janech). Also, this is another big Dayhoff moment for me. She was incredible!

#proteomics #bioinformatics

This is figure 1, which shows the consistent global links between coffee consumption and the human gut microbiome.

Coffee consumption is associated with the presence and abundance of a specific member of the human gut microbiome, Lawsonibacter asaccharolyticus, and changes to the plasma metabolome, according to a paper in Nature Microbiology. https://go.nature.com/3CIl4as 🧪

I'm excited to be speaking about the "Dark" Cancer Immunopeptidome at The Festival of Genomics & Biodata, taking place on the 29th-30th of January 2025 at ExCeL London.

hubs.la/Q02TpxPP0
Registration is free for over 90% of attendees.
#FOG2025 #Proteomics #Genomics #Bioinformatics #Immunopeptidome

The Festival of Genomics & Biodata is BACK in London with more topics, more choice and more speakers than ever before! After last year’s record attendance, #FOG2025 is now the UK’s largest life sciences event. Find out more here: www.festivalofgenomics.com/london
#genomics #biodata