Julie Miesch

Our latest work, in collaboration with the terrific @kashishsingh.bsky.social in the Carter lab @mrclmb.bsky.social is out. So proud of this study and everyone involved...

Tubulin autoregulation tunes microtubule dynamics to support multicellular architecture and viability Alpha- and beta-tubulin heterodimers dynamically assemble into microtubules, key cytoskeletal elements involved in intracellular trafficking, cell adhesion and division. The availability of free tubul...

🔎New preprint!
We reveal a physiological role for tubulin autoregulation, fine-tuning microtubule dynamics and preserving 3D cellular architecture.
Big thanks to @ivanagasic.bsky.social and team!
Link below for all #cytoskeleton & #spheroid enthusiasts👇(1/5)
www.biorxiv.org/content/10.1...

📢 Deadline extended to Join Arolla 2025!
📅 Aug 25–29, Grand Hotel, Arolla
🌍 For junior & senior scientists in cutting-edge bio research
🧬 Abstracts + reg close August 11
💸 Discounts for LS2 members!
👉 Info & reg: meetings.ls2.ch/arolla2025

Disorder meets its match Designed protein pockets recognize intrinsically disordered protein regions

Designed protein pockets recognize intrinsically disordered protein regions @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.statnews.com/2025/07/17/n...

Mosaic evolution of clathrin-mediated endocytosis in fungi Picco et al. take an evolutionary approach to study clathrin-mediated endocytosis in a fungal clade and discover that the process is evolving in a mosaic fashion. The early phase of endocytosis has sh...

How does evolution shape ancient cellular processes? Our new paper uncovers the mosaic evolution of conserved and diverging endocytic traits in fungi!

www.cell.com/current-biol...

New preprint out! We show how cellular nematic order can be harnessed to program tissue-wide force fields and guide 3D shape transformations.

The tissue morphogenesis logic, now engineered into living, programmable materials.

www.biorxiv.org/content/10.1...

#ActiveMatter #TissueEngineering

Postdoctoral Scientist - Structural Studies - Dr Sjors Scheres - LMB 2640 - Cambridgeshire job with MRC Laboratory of Molecular Biology (LMB) | 12840844 Postdoctoral Scientist Starting Salary: £41,344 Fixed term: 3 years MRC Laboratory of Molecular Biology, Cambridge, UK We are looking for a postdoc...

We have a 3-year funded postdoc position to work on structures of #amyloid filaments. If you are an expert in protein biochemistry, structural biology or #cryoEM / #cryoET, this could be for you! Feel free to email me with any questions. Come join us! 🤩

www.nature.com/naturecareer...

Localization of WDS proteins and fimbrin in three fungal species.

How do cells switch on the actin assembly at endocytic sites? How can this on-switch evolve? Check out our new preprint!
www.biorxiv.org/content/10.1...

A picture of 3 rows of people on steps at the MRC LMB. From left to right - top row: Akaash, Vic, Lara - Middle row: Kerrie, Manu, Paddy - bottom row: Meg and Julie

🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...

#STEMCareers #ResearchJobs

Great opportunity for a Research Support Officer to join @cellbiol-mrclmb.bsky.social, supporting @deriverylab.bsky.social in their studies of the molecular mechanisms behind receptor sorting in endosomes.
More info: www.nature.com/naturecareer...
Apply by 10 JUL
#ScienceJobs

🤩 Last week I successfully defended my PhD!
It was such a special day, made even better by having friends, family, and colleagues there with me. Thanks for all the support and kind words!
Huge thanks to my jury members for the thoughtful feedback and conversations.

@soldatilab.bsky.social

🚨 New preprint!
Using U-ExM + in situ cryo-ET, we show how C2CD3 builds an in-to-out radial architecture connecting the distal centriole lumen to its appendages. Great collab with @cellarchlab.com @chgenoud.bsky.social @stearnslab.bsky.social 🙌. #TeamTomo #UExM
www.biorxiv.org/content/10.1...

Congrats Dr Perret 🥳🥳

Temporal and spatial coordination of DNA segregation and cell division in an archaeon. Cells must coordinate DNA segregation with cytokinesis to ensure that each daughter cell inherits a complete genome. Here, we explore how DNA segregation and division are mechanistically coupled in ar...

We are excited to share our preprint describing how Sulfolobus cells coordinate DNA segregation with cell division! In eukaryotes this type of regulation involves checkpoints and CDK-cyclins. But how does this work in archaea? This is the question we ask in our paper: www.biorxiv.org/content/10.1...

New lab preprint! Unveiling the Molecular Architecture of T Cells and Immune Synapses with Cryo-Expansion Microscopy (Cryo-ExM). A fantastic collaboration with Dr. Benita Wolf. Congratulations to all authors, especially Florent Lemaitre, for leading this amazing work! www.biorxiv.org/content/10.1...

Latest paper from the lab @cellbiol-mrclmb.bsky.social, Anna's PhD work hot off the press @plosbiology.org ! Using single cell genomics to understand tube morphogenesis, and why it's as important to switch things off as it is to switch them on!

Interplay of actin nematodynamics and anisotropic tension controls endothelial mechanics Nature Physics - Blood flow through a vessel deforms vessel walls. Cells lining these walls sense the changes in pressure as blood flows and reorient their actin fibres in the direction of largest...

Very happy and excited to share our latest work linking actin nematodynamics and endothelial cell mechanics under anisotropic tension, now published in @natphys.nature.com ! rdcu.be/eigWi

@ipparis.bsky.social @polytechniqueparis.bsky.social

Excited to announce the Molecular Biology of Archaea (MBoA) 2026!

Join us in Cambridge, UK, from 6–10 July 2026 for the only international meeting dedicated to Archaea.

ESCRT function, evolutionary diversity and mechanism of action The ESCRTs (Endosomal Sorting Complexes Required for Transport) were discovered in 2002 and became one of the most dynamic fields of research in membrane cell biology. ESCRTs are protein complexes fo…

A short reminder that registrations for the EMBO ESCRT meeting 2025 in Montreux June 23rd-June27th are still opened! Please register online at meetings.embo.org/event/25-escrt

Emmanuel Derivery. Image Credit MRC Laboratory of Molecular Biology.

In our latest interview, we hear from the 2024 @bscb-official.bsky.social Hooke Medal winner Emmanuel Derivery @deriverylab.bsky.social. Emmanuel tells us about his research, what winning the Hooke Medal means to him & his advice on building a successful lab.
journals.biologists.com/jcs/article/...

Join Adam's Lab! He is an amazing scientist and the project is so cool!

Congrats Sandra 🥳, well deserved!

Congratulations to Dr. @guallar-garrido.bsky.social on her new lecturer position at the Autonomous University of Barcelona! She will keep working on mycobacteria using amoeba host model. Best of luck on this exciting new chapter! 👏🔬✨

Hydrolysis-deficient mosaic microtubules as faithful mimics of the GTP cap Nature Communications - Estévez Gallego et al. present a study demonstrating that mosaic microtubules consisting of a mix of GTP hydrolysis-deficient tubulin mutants are faithful microtubule...

We're on a roll!🚀
Check our latest research @naturecomms.bsky.social: rdcu.be/ecXzr
We reveal how mosaic MTs faithfully mimic the GTP cap, highlighting lattice expansion (not pf twist) as the structural cornerstone of MT stability and dynamic instability.

Congrats to Juan and everybody involved! 🎉

Direct-view oblique plane microscopy The ability to rapidly image mesoscopic samples is critically important for many areas of biological research. Owing to its high throughput and gentle, volumetric imaging nature, light-sheet fluoresce...

We present:

Direct-view oblique plane microscopy

www.biorxiv.org/content/10.1...

New: Colombo et al. @surreylab.bsky.social show that NuMA is a mitotic dynein adaptor that binds and caps microtubule minus ends, explaining how dynein, NuMA, dynactin, and Lis1 focus microtubule minus ends at mitotic spindle poles https://buff.ly/41aj9F9

Extremely happy to see our work finally out!🎉 Great collaboration between @rouxlab.bsky.social @buzzbaum.bsky.social labs and a real pleasure to work and share co-first authorship with incredible scientists and friends @diorgeps.bsky.social @sami-c.bsky.social. Big thanks to the rest of the authors!

Micro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing - Nature Communications Modelling the tumour immune microenvironment in vitro is a valuable tool to test immunotherapy efficiency but capturing its complexity is challenging. Here authors present a fully humanised in vitro p...

Finally out! 🎉 Really happy to share my first co-author paper!

It was wonderful to work with @aliperri.bsky.social , and huge thanks to @xaviertrepat.bsky.social for the opportunity to be part of this project. Grateful to the whole team for making this happen!

www.nature.com/articles/s41...

Now hiring: Research Group Leader Structural Studies Division To develop artificial intelligence/machine-learning methods to further our understanding of biology at molecular and/or cellular scales Apply by 18th March

Join our Structural Studies Division, leading a research group developing computational methods to address questions in molecular & cellular biology!
You will be supported by core funding, excellent facilities & enthusiastic colleagues.
Apply by 18 MAR
www.nature.com/naturecareer...

Lara Krüger, stood in the LMB atrium, smiling.

Congratulations to @lara-kruger.bsky.social, postdoc in @deriverylab.bsky.social in @cellbiol-mrclmb.bsky.social, who is leaving the LMB to establish her own research group at @institutcurie.bsky.social in Paris!
Best of luck to you Lara!
#LMBAlumni