Henri-François Renard

Bending the boundaries: the many facets of endophilin-As from membrane dynamics to disease - Cellular and Molecular Life Sciences The endophilin-A proteins (EndoAs) are Bin/Amphiphysin/Rvs (BAR) domain proteins with key roles in both clathrin-mediated (CME) and clathrin-independent endocytosis (CIE). Humans have three differentially expressed EndoAs, EndoA1, -A2, and -A3, encoded by the SH3GL2/1/3 genes, respectively. Their functions primarily arise from their N-terminal BAR domain, which senses and induces local membrane curvature, and C-terminal SH3 domain, which mediates interactions with various proline-rich domain-containing partners. Among others, EndoA-mediated endocytosis coordinates synaptic vesicle recycling, as well as internalization of cell adhesion molecules, ligand-stimulated receptors, and pathogens. Consequently, EndoAs influence key cellular processes like neurotransmission, signaling, cell adhesion, and infection. Importantly, EndoA dysregulation has been observed in several pathologies, notably neurodegeneration, cardiovascular diseases, and cancer. This review provides an overview of the function and regulation of the EndoA proteins in CME and CIE, and explores their lesser-characterized involvement in other processes such as autophagy. It further addresses how these functions contribute to physiological processes and the development of pathologies, with a particular focus on cancer pathophysiology. Together, it emphasizes non-redundant roles of EndoA proteins in various cellular processes and highlights the complex relationship between membrane trafficking and diseases.

🚨 New review alert! 🚨
Everything you ever wanted to know about endophilin-A proteins—all in one place.
A huge congrats to the team for this tour de force: @shiqiang.bsky.social, Emilie Rigaux, Dorian Hène & Louise Thines!
👉 link.springer.com/article/10.1...

23.09.2025 15:50 — 👍 2    🔁 1    💬 0    📌 0

A full-time academic position in biochemistry UC Louvain (Belgium) -Louvain Institute of Biomolecular Science and Technology (LIBST)

exoendo.org/en/offre-dem...

09.09.2025 15:29 — 👍 1    🔁 2    💬 0    📌 0

Thanks @fbaschieri.bsky.social and @hessofarhan.bsky.social for warm welcome in Innsbruck. It’s always a pleasure to meet your students, and discuss science and life around science with you 😎 Happy to see that François Tyckaert is blossoming in your environment 👌🏻

13.06.2025 22:03 — 👍 4    🔁 0    💬 0    📌 0

Emotional moment as my first PhD student as an independent PI defended his PhD thesis yesterday. Congrats Dr Xu @shiqiang.bsky.social 👨‍🎓👏🏻👏🏻👏🏻 I have been extremely lucky to count on you to start the lab #proudmentor. I wish you all the best for your next career step in @volkerhaucke-lab.bsky.social 💪

12.03.2025 13:38 — 👍 5    🔁 1    💬 0    📌 1

First PhD student finishing since I started my lab as a PI… Emotional moment 🥲 Fingers crossed for your public defense next week and already congrats @shiqiang.bsky.social 😎🍾👏🏻

07.03.2025 11:22 — 👍 6    🔁 1    💬 0    📌 0

"Growth factor-triggered de-sialylation controls glycolipid-lectin-driven endocytosis" An excellent collaboration between the US, India, Denmark, UK, Netherlands and France.

Growth factors trigger receptor desialylation at the plasma membrane, galectin binding and subsequent endocytosis.

=> A proton pump driven glycoswitch @naturecellbiology.bsky.social :

rdcu.be/eaLM9

#glycotime, @institutcurie.bsky.social, @cnrs.fr, @inserm.fr, #NIH, #CellBiol, #Cancer

22.02.2025 22:31 — 👍 16    🔁 3    💬 2    📌 1

@shiqiang.bsky.social on BlueSky 😎

19.02.2025 12:07 — 👍 1    🔁 0    💬 0    📌 0

Congratulations to Shiqiang XU for this hard PhD thesis work at the interface of #membranetrafficking and #immunology, and to all coauthors! A collaborative effort between UNamur, UCLouvain and @institutcurie.bsky.social 🤝

🚧 Revision work starts now 🚧 We take any suggestion to improve our data 🤓

19.02.2025 09:53 — 👍 3    🔁 0    💬 1    📌 0

Clathrin-independent endocytosis and retrograde transport in cancer cells promote cytotoxic CD8 T cell activation

🚨 Check our latest study 🚨 Now online as a reviewed preprint at @elife.bsky.social : doi.org/10.7554/eLif...

Interested in unconventional #endocytosis and #retrogradetransport mechanisms in cancer cells, and how this impacts cancer cell detection by the #immune system? This manuscript is for you 🫵

19.02.2025 09:53 — 👍 8    🔁 3    💬 1    📌 0

First lab picture on Bluesky 😎 Some delicious Belgian beers to celebrate the success of our two master students of 2024, Laura and Kilian! Congrats guys 👏🏻 And good luck for your next internship across the ocean 🇨🇦

31.01.2025 08:18 — 👍 10    🔁 1    💬 0    📌 0

One solution : come to Belgium 🤗

17.12.2024 23:19 — 👍 1    🔁 0    💬 0    📌 0

Clathrin-independent endocytosis and retrograde transport in cancer cells promote cytotoxic CD8 T cell activation https://www.biorxiv.org/content/10.1101/2024.10.28.620627v1 Clathrin-independent endocytosis (CIE) mediates the cellular uptake of endogenous and exogenous carg

Clathrin-independent endocytosis and retrograde transport in cancer cells promote cytotoxic CD8 T cell activation https://www.biorxiv.org/content/10.1101/2024.10.28.620627v1

30.10.2024 09:31 — 👍 3    🔁 1    💬 0    📌 0