Jason Murphy

Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport

Something super hopeful:
A way to treat Alzheimers that is totally new and was just shown to work amazingly in mice.

Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport | share.google/U23UhLehCUUC...

Mice treated with the new drug (middle column in each group of 9) were way better at building nests than the ones who got the sham treatment (left column). They were more like the "wild type" mice who weren't engineered to have mouse Alzheimers(right column). 🐭

Repairing the Blood Brain Barrier Reversed Alzheimer's Disease in Mice, a Hopeful Result for Humans Merging biophysics with knowledge of how the brain handles waste led to an impressive 50 percent reduction of amyloid beta in mice brains and restoration of cognitive function.

News story spells it out nicely. Brains dump all the toxic junk immediately. They found a lot of the amyloid was gone inside an *hour*. And the mice were like young mice again 6 months later. www.discovermagazine.com/repairing-th...

Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport

Something super hopeful:
A way to treat Alzheimers that is totally new and was just shown to work amazingly in mice.

Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport | share.google/U23UhLehCUUC...

Could you eat for a week for $50?

Rice, lentils, oats and frozen vegetables will get you a long way. But even this menu assumes luxuries that people experiencing poverty simply cannot access, @jasemurphy.bsky.social writes.

New PB at Aldi! No special buys but a few bottles of booze.

Tomorrow I'm doing that.

I did over 15000 days in a row the same: I ate things. And then, bam. I **stopped**.
Trying #fasting.
3 days in, it's not impossible but still, awful! Here's to another 15000 back in the old mode!

#aflgf post.
I forecast a day where the half-time kick-to-kick stretches out for the neutrals: the Cats will have all but buried them by half time.
A few consolation goals and let's say a 33 point final margin. #aflcatslions #GoCats

Which would mean using supermarket checkout data not surveys on tobacco purchases.

No the basket is weighted! I agree they should measure only legal tobacco sales if they want to be fair and consistent with drugs

The ABS is opposed but if those things become a big enough factor imo they should!

(confounder: I stop exercising when things get hard, but I promise my future self that next time this happens I'll drop something*else* and not the silver thread holding together my mental well-being!)

What should be different is we should not let organized crime run amok in a booming market!!

CPI measures what Australians buy. They should be in there!

There's heavy philosophy about the path to happiness but for me the recipe is just embarrassingly *corporeal*.
A tendency to joy transforms to existential despair if I simply. stop. exercising.

Smokes are not the biggest contributor to the CPI, but for such a small component of the basket they weigh heavily, because the official price keeps rising so quickly. Total CPI was up 1 percentage points, of which .06 was tobacco price rise. 2/2 🚬

Regular reminder: Australia's inflation data is overstated because they sample the price of legal cigarettes, which are up 12 per cent. And not the cigarettes people buy, which are cheaper than they have been for a decade. #ausecon 1/2

It's run for shareholders but those big financial firms are not the true owners, they hold the shares for the true owners (pension funds, hedge funds etc) . These lists are always tripping people up! www.smh.com.au/politics/fed...

black car with a red x and a bright yellow car with a green check mark. It's getting dark out earlier, be sure to add a bright coat of paint to your vehicle. Remember road safety is a shared responsibility.

Shared Responsibility.

@thebikinglawyer.bsky.social

I did not know Oz was associated with iHerb!

Folinic acid though, is miles out of patent, it's just a vitamin (particular form of b9). Thousands of makers, thousands of sellers.

"Mass Psychogenic Illness" at Heathrow Airport-NOT! On a Guardian article about a recent incident at Heathrow Airport where some people reported feeling ill. It was assumed to be a psychosomatic event by among others Professor Wessely, until someone with tear gas got caught. "This incident is a classic example of how quickly those with authority will turn to psychiatric or psycho-sociological assumptions to explain unusual medical phenomena–assumptions that are often asserted as definitive rather than speculative."

"Mass Psychogenic Illness" at Heathrow Airport-NOT! by David Tuller @davetuller1.bsky.social

virology.ws/2025/09/12/t...

Image is screenshot from latest Science for ME weekly update

Chicken or the chip: How can meat suddenly cost less than potatoes? A curious thing is happening in Australia's supermarkets...

My grandparents couldn't imagine this: meat less per kilo than spuds... www.crikey.com.au/2025/09/18/p...

Day6
Km Takayasu 0-5 (L)
Km Aonishiki 3-2 (R)
Another installment of “blunting Ao’s attack” laboratory. #Akibasho2025

I was there!!

Chicken or the chip: How can meat suddenly cost less than potatoes? A curious thing is happening in Australia's supermarkets...

My grandparents couldn't imagine this: meat less per kilo than spuds... www.crikey.com.au/2025/09/18/p...

Tough game for neutrals , gotta concede it!! If you want to find the Cats loveable you have to focus on Mannagh, who was playing VFL age 25 three years ago. He'll kick a bag tonight. And Mullin, who had not touched a sherrin three years ago!

You'd think free-floating hemoglobin from hemolysis would have been found previously if it existed in PEM? Free hemoglobin is super bad, it affects nitric oxide which helps control vascular tone (POTS link)!

Very obvious follow up is to check the allele frequency in cases and controls!! And then try to figure out if there is hemolysis going on- is that why haptoglobin is elevated?? If so is it due to erythrocyte shear stress in narrow capillaries as reported by Wust et al??

Anyone else going to the MCG tonight?! #aflcatshawks. I'm beside myself🫣😬🫨🥺🙀!!