Manuel Mendoza

We all know about the Claude spiritual bliss attractor state. But what happens when you let Grok talk to itself for a long time? Answer:

Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...

Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation | Science www.science.org/doi/10.1126/...

I'm exhausted from reading 'not X but Y' sentence structures.

It's a hallmark of AI, and that's fine, but the issue is that sometimes I find it every other paragraph!

1/3 New bioRxiv preprint from the lab: “Minute-scale coupling of chromatin marks and transcriptional bursts”. Led by Xiohui Gao & Chaebeen Ko. bioRxiv : www.biorxiv.org/cgi/content/...

Direct visualization and tracing of chromatin folding in the Drosophila embryo - The EMBO Journal Chromatin organization, through the assembly of DNA with histones and the folding of nucleosome chains, regulates DNA accessibility for transcription, DNA replication and repair. Although models deriv...

We are in EMBO J. See DNA and non-octameric nucleosome-like particles in situ

link.springer.com/article/10.1...

This graph basically shows that the MSCA are, as of now, useless unless the EU governance does something about it 🧪

📣 Please spread: we’re hiring a Lab Manager! It is a critical position in our new lab. As our lab moves to Barcelona and joins the @crg.eu, we’re looking for a Lab Manager to help build the lab and set the lab atmosphere.
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...

Postdoc job alert at Institut Jacques Monod in Paris! Interested in fundamental membrane trafficking? We seek a postdoc to study collagen secretion as a model for core principles of how cells and their environment build each other. emploi.cnrs.fr/Offres/CDD/U...

🧬 #Yeast condensin does more than organize chromosomes.
New study shows it acts as a transient crosslinker in entangled DNA, stabilizing entanglements rather than resolving them. This challenges current models of chromosome organizing proteins.
#YeastResearch #SGD
www.yeastgenome.org/reference/S1...

The Muppet Show on Disney+ is glorious.

They haven't tried to update it, or twist it in any way. It's just The Muppet Show you watched when you were a kid.

Cryo-EM Facility Manager | King's College London

Hi all- we are searching for a new manager/operator to run and develop KCL's Cryo-EM Structural Discovery Facility: a JEOL cryoARM200 + k3 and sample preparation equipment. This 200kV set up recently achieved a 1.2 Å apoferritin! www.biorxiv.org/content/10.6...

www.kcl.ac.uk/jobs/137165-...

Polls Show Strong G.O.P. Support for Trump on Immigration

So much here that I just cannot wrap my head around...
"Asked about the shooting of Ms. Good, more than half of Republicans said it was a necessary use of force. Asked about Mr. Pretti, just 33 percent said it was a necessary use of force. A large share, 43 percent, said they were not sure."

Please repost and consider applying: we work in such a fantastic context, we ask so interesting questions, and we have such a collegial and best-willing atmosphere… CRBM = Happy & Good Science

Seeing Chromatin Scaling with Cell Size, from Interphase to Mitosis - FocalPlane Seeing Chromatin Scaling with Cell Size, from Interphase to Mitosis -

Melike Lakadamyali @melikel.bsky.social, Jérôme Solon and Manuel Mendoza @longchrom.bsky.social share the behind the paper story of their research interrogating how chromosome compaction scales with cell size using a combination of live confocal microscopy and 3D STORM.

Mitosis has a timing system. If chromosomes attach properly, cells divide on schedule and keep proliferating. If attachment is slow or incomplete, the delay is recorded — and daughter cells stop dividing.
We explore this link in our new preprint.

🔗 www.biorxiv.org/content/10.6...

YouTube video by Bruce Springsteen Bruce Springsteen - Streets Of Minneapolis (Official Audio)

I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good.

Stay free

Seeing Chromatin Scaling with Cell Size, from Interphase to Mitosis - FocalPlane Seeing Chromatin Scaling with Cell Size, from Interphase to Mitosis -

Thanks to @focalplane.bsky.social for the invitation to highlight our recent @biophysj.bsky.social paper! With @melikel.bsky.social and Jérôme Solon, we combined super-resolution and live imaging to connect interphase chromatin organisation to mitotic chromosome compaction across cell sizes.

I’ll soon share a call for a postdoc at Institut Jacques Monod (Paris) on fundamental mechanisms of membrane traffic and protein/collagen secretion in health and disease. Please get in touch if interested.

“A student joining a lab is often presented with a hypothesis to work on and may see science as a hypothesis-testing endeavor. Many young postdocs have been told that as a PhD student their job was to answer questions—now they have to discover their own unknown unknowns.”

(Hom)mage du Kremlin. « ‘Le Mage du Kremlin’ (le film) est à peu près le meilleur cadeau que nous puissions faire au Kremlin (le vrai). » J’ai posté ce commentaire hier sur les réseaux sociaux, en sortant de l…

Comme promis, un texte où je persiste et signe : le film "Le mage du Kremlin" est dangereux, car il se met au service du pouvoir russe en diffusant une vision du pays exactement conforme à ce que le Kremlin veut nous faire penser.
colinlebedev.fr/2026/01/22/h...

Frodo: I wish so much unbelievably stupid shit had not happened in my time Gandalf: So do all who live to see such times. This is all exceptionally stupid, though

We are looking for a postdoc to work on mechanisms of #RNA decay in cancer using #cryoEM with #nanobodies and #minibinders! Please RT

Photograph from 1911 taken by Herbert Ponting whilst with Scott's Antarctic Expedition The monochrome photo is taken from within a cave. The walls of the cave are made of ice. The cave entrance is in the mid distance with two figures standing looking out towards a distant ship. Between them and the ship there is first a 'beach' of ice before the sea itself. The ship could be up to 800 metres away What makes the photo so special is that where the figures are at the cave entrance there is a band of very white snow and ice (contrasting with the comparatively dark inside of the cave) that creates a stark framework in which the men and the ship are captured. It is made even more dramatic by the fact that the cave entrance is at least 30 metres high and is in the shape of a distorted elipse with the tail sloping off to the right at the top of the elipse The photo being in monochrome in a largely white environment makes the photographers skill all the more laudable

This photo was taken in 1911 using glass plate technology by Herbert Ponting who was part of Scott's Antarctic expedition,

The composition and detail are exquisite with the band of white snow/ice creating a perfect frame around the two people and the ship in the distance

Iconic imo

Controversial CDC hep B vaccine study in Guinea-Bissau may be canceled

Who’s behind this? The answer will not surprise you www.cidrap.umn.edu/childhood-va...

This is nuts

1/10
In this thread we will explain you how we put together
#SPT #SMLM #cryoET #cryoCLEM + #modeling
to learn about the higher-order mechanism that controls exocytosis (constitutive exocytosis, the one😜)

(Illustrative animation made by the amazing Dylan Godfrey)

Continuum architecture dynamics of vesicle tethering in exocytosis Data from complementary imaging techniques were integrated into a model that resolves the dynamic exocyst ensemble and membrane architecture during exocytosis, an essential cellular pathway. Sec18 med...

0/10
🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology

Continuum architecture dynamics of vesicle tethering in exocytosis
www.cell.com/cell/fulltex...

Scientists turn cells’ most mysterious structures into spies on genetic activity Enigmatic ‘vaults’ can be engineered to eavesdrop on RNA, aiding cancer studies and more

@science.org Scientists turn cells’ most mysterious structures into spies on genetic activity | Science | AAAS www.science.org/content/arti...

Congratulations!

Happy to share that the our manuscript "Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth" is now finally out in its final form @natcomms.nature.com
www.nature.com/articles/s41...
Below a short🧵 with the key findings!