Adrian Wanner

The songbird basal ganglia connectome The basal ganglia (BG) play an essential role in shaping vertebrate behavior, ranging from motor learning to emotions, but comprehensive maps of their canonical synaptic architecture are missing. In m...

I am happy to share that the main story of my PhD is now available as a preprint! www.biorxiv.org/content/10.1...

We analyses over 8500 neurons in a songbird basal ganglia dataset.

To explore this and two other stories more interactively, also check out our website!
www.songbird-connectomics.org

So proud of my new lab! Check out the recent songbird basal ganglia connectome - great job @alexandrarother.bsky.social !!
@jmrko.bsky.social !!

songbird-connectomics.org

Thank you so much @wellcometrust.bsky.social for supporting us to push the the limits of #X-ray #nanoimaging and #connectomics, and to make technology more broadly available to the scientific community! 🙏

Excited to try this! The waiting list makes me even more curious

The Crick is an absolutely amazing place to work in - please share this opportunity widely with your colleagues and postdocs - and DM me if I can help in any way

Apply now!!! 🔥

Interesting papers on the role of cell organelles in neuronal dendrites for calcium signaling Researchers utilize calcium imaging to track neuronal activity in the brain, highlighting the role of calcium as a signaling molecule. Recent studies investigate intracellular calcium dynamics, par…

New blog post, where I review some recent interesting papers on the role of cell organelles for neuronal calcium signaling: gcamp6f.com/2025/08/11/i...
Featuring work by @lorenabenedetti.bsky.social, O'Hare et al. and Lin et al.!

Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context https://www.biorxiv.org/content/10.1101/2025.09.26.678648v1

Great opportunity to work with an amazing team on the frontiers of X-ray connectomics www.psi.ch/en/hr/job-op...

Hard X-ray imaging of biological soft tissues symposium 2025

#Nanoimaging symposium @crick.ac.uk!

At #CrickXrays25 we'll tackle:
💫synchrotron upgrades
📈current limits in throughput, volume, resolution
🧪sample preparation for X-ray PC imaging
🧠♥️applications in neuroscience and tissue life science

🗓️13th October 2025
🇬🇧🌐 London & online
tinyurl.com/crickxrays25

This is fantastic news, congratulations! Very well deserved!

Supervised learning in DNA neural networks - Nature DNA molecules can be programmed to autonomously carry out supervised learning in vitro, with the system learning to perform pattern classification from molecular examples of inputs and desired responses.

Nature research paper: Supervised learning in DNA neural networks

go.nature.com/4mOb9lH

Highly recommended

It was a good experience to step back and briefly take stock of the amazing progress in connectomics since I started working on this stuff (20 years ago!)

thanks as well to @natrevneuro.nature.com for the constructive editorial interactions.

Multiplexed Neuromodulatory-Type-Annotated EM-Reconstruction of Larval Zebrafish https://www.biorxiv.org/content/10.1101/2025.06.12.659365v1

Recurrent connectivity supports carbon dioxide sensitivity in Aedes aegypti mosquitoes The mosquito Aedes aegypti′s human host-seeking behavior depends on the integration of multiple sensory cues. One of these cues, carbon dioxide (CO2), gates odorant and heat pathways and activates hos...

New preprint from @darbly.bsky.social‬ @briandepasquale.bsky.social‬ and my labs! If you love (or hate) mosquitoes, have a look:

doi.org/10.1101/2025...

We used TEM to describe the circuitry used for CO2 detection by mosquitoes. As usual with mosquitoes, nothing is as expected! 🌬️🦟

The first full central nervous system connectome dataset of an adult fly, with the most comprehensive annotation of sensory and motor neurons to date.

A heroic effort with contributions from many groups, a product of the collaborative spirit of the Drosophila neuroscience community.

Comparative connectomics of two distantly related nematode species reveals patterns of nervous system evolution Understanding the evolution of the bilaterian brain requires a detailed exploration of the precise nature of cellular and subcellular differences between related species. We undertook an electron micr...

Happy to share our publication - Comparative connectomics of two distantly related nematode species reveals patterns of nervous system evolution www.science.org/doi/10.1126/...

Fantastic to see this collaborative work with Hopi Hoekstra out in Nature (tinyurl.com/3at3zvby). Lead by @felixbaier.bsky.social and @katjareinhard.bsky.social. Not possible without @bramnuttin.bsky.social , Chen Liu and @arnausd.bsky.social.

Excited to see where this work leads.

Connectomic reconstruction from hippocampal CA3 reveals spatially graded mossy fiber inputs and selective feedforward inhibition to pyramidal cells The mossy fiber (MF) connections to pyramidal cells in hippocampal CA3 are hypothesized to participate in pattern separation and memory encoding, yet no large–scale neuronal wiring diagram exists for ...

Excited to share a connectomics dataset of hippocampus CA3.
Explore the dataset: pyr.ai
Paper introducing the dataset and some of our discoveries: www.biorxiv.org/content/10.1...

Kedar Narayan (right) holds the Alan Agar Award, presented by Paul Verkade (left), who is holding Kedar's certificate. They are both smiling, standing next to a lectern inside a lecture hall.

Huge congratulations to Kedar Narayan who received the RMS Alan Agar Award for #ElectronMicroscopy from Paul Verkade this afternoon at #mmc2025

👏👏👏🔬🙌🥇

@rmsearlycareer.bsky.social @yorkbioimaging.bsky.social

Congratulations Aaron, very well deserved!

Proud to share our latest paper. doi.org/10.1016/j.cr...

Through the dedication of @glynnca.bsky.social and @cryingem.bsky.social we report a thorough method to image molecular organisation within hippocampus tissue.

Structural biology in tissue is well and truly here!

@rosfrankinst.bsky.social

If you want to learn the latest developments in volumeEM from the experts, with hands-on experience on our instruments @embl.org, this course is for you! 🔬

Introducing warpfield, an open source Python library for GPU-accelerated non-rigid 3D registration. Warps and aligns gigavoxel volumes within seconds (not hours). For 3D microscopy, region-to-region and cell-to-cell matching.
A collaboration with @mh123.bsky.social 🚀
github.com/danionella/w...

Linking function and structure at scale with X-rays - and several times over. Massive congratulations to the team ‪@yuxinzhang.bsky.social‬, @carlesbosch.bsky.social, @apacureanu.bsky.social @esrf.fr, @crick.ac.uk and all our collaborators.

#preprint:

We mapped the structure and function of olfactory bulb circuits with in vivo 2-photon microscopy and synchrotron #Xray holographic nanotomography.

doi.org/10.1101/2025...

@yuxinzhang.bsky.social @andreas-t-schaefer.bsky.social @apacureanu.bsky.social
@crick.ac.uk @esrf.fr

I am honored and excited to announce that I will be starting as group leader at @dandrite.bsky.social and associate professor at @au.dk in August 2025. I look forward very much to joining my future colleagues in Aarhus in doing excellent Neuroscience, with many scientific puzzles ahead to solve!

I am very happy and thankful for having been part of this amazing journey. Enjoy exploring this incredibly rich dataset!

To stop intimidation, Eisgruber needs your help When targeting one institution is a bald attempt to divide and conquer, as is the case with Columbia, it is essential for a coalition or group of institutions and individuals to stand up together.&nbs...

Here at Princeton, we’re amplifying our university president’s leadership. It’s time for everyone - faculty, students, staff - to speak out.

tl;dr: rights can’t be blackmailed.

From me and science colleagues:
www.dailyprincetonian.com/article/2025...