@adrianawanner.bsky.social
SERI-funded #ERCStG Group Leader at PSI https://structuralneurobiology.ch, CV Starr Fellow at Princeton Neuroscience Institute, founder of https://ariadne.ai
What it's like to be a connectome
06.02.2026 07:44 — 👍 4 🔁 0 💬 1 📌 0
The winner of the 2026 Pradel Research Award is H. Sebastian Seung of @princetonneuro.bsky.social! He is being honored for for transformative advances in computational neuroscience. Learn more about his discoveries: www.nasonline.org/award/pradel... #NASaward #neuroscience
22.01.2026 16:06 — 👍 13 🔁 4 💬 1 📌 0What's the relation between voltage and calcium in dendrites? Xiang Wu studied this in CA2 hippocampal pyramidal cells in behaving mice. www.biorxiv.org/content/10.6...
21.01.2026 19:50 — 👍 58 🔁 17 💬 1 📌 0
🔬🔦Our latest ‘Imaging spotlight’, by @carlesbosch.bsky.social, Ana Diaz, @adrianawanner.bsky.social & @andreas-t-schaefer.bsky.social, highlights the non-destructive X-ray tomography pipeline that the authors developed to map mouse brain ultrastructure & considers future applications & developments.
14.01.2026 11:14 — 👍 11 🔁 4 💬 0 📌 1
Poster of the EM course in Naples with marine samples. The Electron Microscopy Hands-On Course: sample preparation and imaging of marine environmental samples arises from a very strong and active collaboration between the Stazione Zoologica Anton Dohrn and the EMBL in Heidelberg. The aim of the course is to provide a theoretical and practical training on electron microscopy starting from the basics to the preparation of samples with high pressure freezing and image acquisition using TEM and SEM.
If you are interested in electron microscopy, registration is still open for the
"Electron Microscopy Hands-On Course: sample preparation and imaging of marine environmental samples"
at Stazione Zoologica in Naples.
WIth great teachers from Naples […]
[Original post on biologists.social]
Two nerve nets are formed in Hydra vulgaris: the endodermal (cyan) and the ectodermal (purple) net. (B) Intraepithelial neurons are randomly scattered between the epithelial cells of the two germ layers. (C) Two types of connections have been found between Hydra’s neurons. (D) Endodermal neurons are in physical touch with each other by forming neural handshakes by digiform endings, which get intertwined. (E) In other places, clusters of vesicles of different types can be released to mediate volume transmission between neurons and between neurons and other cells.
Our dispatch:
https://www.sciencedirect.com/science/article/pii/S0960982225014691
on the recent Hydra volume EM paper by Zhang, Rafa Yuste and colleagues:
#connectomics, without synapses
https://www.sciencedirect.com/science/article/pii/S0960982225013090
#neuroscience
A paper from my PhD lab is on Science! This is a really cool new way to utilize EM connectome datasets. Congrats to the team!
www.science.org/doi/10.1126/...
How do neural circuits generate the walking rhythm?
Using connectome simulations, @sarahpugly.bsky.social found a minimal central pattern generator (CPG) that produces oscillations in leg motor neurons. Same circuit motif for each 🪰 leg.
w @bingbrunton.bsky.social
www.biorxiv.org/content/10.1...
Last night Adam Kampff, the glue, the light, the catalyst, the builder, the smile, left us. He and his work transformed the lives of many labs, scientists, students. He inspired and was generous to his last transformation, working tirelessly to set up a foundation to continue the work.Thank you!
09.12.2025 15:37 — 👍 42 🔁 11 💬 5 📌 6
Our Method of the Year 2025 is...drumroll please...EM-based connectomics!!
Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬
www.nature.com/articles/s41...
Connectomics is Method of the Year 2025!!
@natmethods.nature.com
just released the news nature.com/articles/s41... In my perspective piece, I afford some predictions into the future and compare how we are doing vs. genomics www.nature.com/articles/s41...
Connectomics is method of the year 2025:
www.nature.com/articles/s41...
An optimized X-ray nanotomography method offers an attractive alternative to volume EM for connectomics. @crick.ac.uk @psich.bsky.social psich.bsky.social @adrianawanner.bsky.social @andreas-t-schaefer.bsky.social @ucl.ac.uk @uclnpp.bsky.social
www.nature.com/articles/s41...
Very cool, congrats!
01.12.2025 17:12 — 👍 1 🔁 0 💬 0 📌 0Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41...
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
This work was generously supported by a SERI-funded ERCStG @sbfi.admin.ch @erc.europa.eu
27.11.2025 13:09 — 👍 1 🔁 0 💬 0 📌 0#paper!
X-rays can resolve #ultrastructure in tissues non-destructively.
www.nature.com/articles/s41...
Shoutout to key collaborators at @crick.ac.uk and @psich.bsky.social Ana Diaz, @adrianawanner.bsky.social and @andreas-t-schaefer.bsky.social, and to the whole team that made this possible.
By repurposing a radiation-hard epoxy resin from the nuclear/aerospace industry, we made samples withstand >1.15×10¹⁰ Gy and reached sub-40 nm resolution, revealing axons, dendrites, mitochondria and synapses without sectioning.
27.11.2025 10:21 — 👍 6 🔁 1 💬 1 📌 0In a fantastic collaboration co-led by Ana Diaz (@psich.bsky.social), Carles Bosch @carlesbosch.bsky.social) and Andreas Schaefer (@andreas-t-schaefer.bsky.social) from @crick.ac.uk,we tackled a key barrier in X-ray ultrastructural imaging: achieving <40 nm resolution without destroying tissue.
27.11.2025 10:21 — 👍 4 🔁 1 💬 1 📌 0Happy to share the first paper from my journey at @psich.bsky.social towards X-ray connectomics, now out in @natmethods.nature.com: www.nature.com/articles/s41...
27.11.2025 10:21 — 👍 39 🔁 15 💬 1 📌 0For a decade, my white whale as a neuroscientist has been working to convince public+private funders to "go big" on post-mortem human tissue analysis, so we can define circuit disruptions in disease and just maybe link them with molecular drivers. This remains as tough a sell today as 10 years ago.
17.11.2025 14:23 — 👍 2 🔁 1 💬 0 📌 0Enthusiastic about connectomics and X-rays?
Several positions in our group at Crick for postdocs and senior scientists (permanent!).
DM me if interested – and let’s talk if you are at Sfn next days or at the NIH BRAIN CONNECTS meeting today!
Please share!
Excited to share my most recent postdoctoral work in the Jeanne lab @yaleneuro.bsky.social !
“Sensory processing reformats odor coding around valence and dynamics”
www.biorxiv.org/content/10.1...
We ask: how is a sensory code transformed across multiple stages of processing to inform behavior?
I am happy to share that the main story of my PhD is now available as a preprint! www.biorxiv.org/content/10.1...
We analyses over 8500 neurons in a songbird basal ganglia dataset.
To explore this and two other stories more interactively, also check out our website!
www.songbird-connectomics.org
So proud of my new lab! Check out the recent songbird basal ganglia connectome - great job @alexandrarother.bsky.social !!
@jmrko.bsky.social !!
songbird-connectomics.org
Thank you so much @wellcometrust.bsky.social for supporting us to push the the limits of #X-ray #nanoimaging and #connectomics, and to make technology more broadly available to the scientific community! 🙏
27.10.2025 17:39 — 👍 15 🔁 3 💬 0 📌 0Excited to try this! The waiting list makes me even more curious
15.10.2025 15:56 — 👍 3 🔁 4 💬 1 📌 0The Crick is an absolutely amazing place to work in - please share this opportunity widely with your colleagues and postdocs - and DM me if I can help in any way
09.10.2025 15:00 — 👍 5 🔁 3 💬 1 📌 1
Apply now!!! 🔥
06.10.2025 16:44 — 👍 6 🔁 5 💬 0 📌 0
New blog post, where I review some recent interesting papers on the role of cell organelles for neuronal calcium signaling: gcamp6f.com/2025/08/11/i...
Featuring work by @lorenabenedetti.bsky.social, O'Hare et al. and Lin et al.!
