Tal Sharf

schematic of neural recordings from mouse V1, whole-brain, and hippocampus; neural activity traces from the population, showing more correlated activity in V1 and whole-brain recordings versus more decorrelated activity in hippocampus

What if… spontaneous neural activity 🧠 reflects the baseline rumblings of a brainwide dynamical system initialized for learning? We find that the rumblings have macroscopic properties like those emerging from linear symmetric, critical systems 🧵 #neuroscience #neuroAI www.biorxiv.org/content/10.1...

12.01.2025 19:55 — 👍 302    🔁 82    💬 9    📌 0

Goal-Directed Learning in Cortical Organoids Experimental neuroscience techniques are advancing rapidly, with major recent developments in high-density electrophysiology and targeted electrical stimulation. In combination with these techniques, ...

Awesome work by @mrbadash.bsky.social and the crew at @ucscgenomics.bsky.social
Goal-directed learning in cortical #organoids
www.biorxiv.org/content/10.1...

17.01.2025 22:34 — 👍 7    🔁 2    💬 0    📌 0

Our manuscript preprint is out!

17.01.2025 09:15 — 👍 1    🔁 2    💬 0    📌 0

Our work demonstrates that the emergence of intrinsic computational architectures, defined by low- and high-dimensional activity patterns and neuronal sequences, is an emergent property of neuronal self-assembly and achievable in brain organoid models.

09.01.2025 19:26 — 👍 1    🔁 0    💬 0    📌 0

Phenomena such as "preplay," pre-existing sequence motifs are thought to encode novel experiences and underlie episodic memory retrieval in the human cortex. These motifs have recently been shown to encode non-redundant information beyond latency and rate encoding.

09.01.2025 19:26 — 👍 0    🔁 0    💬 1    📌 0

The use of neuronal sequences to encode sensory input and motor output has been widely studied. However, whether these sequences arise innately through neurogenesis and synaptogenesis (nature) or emerge through sequential experience (nurture) remains unresolved.

09.01.2025 19:26 — 👍 0    🔁 0    💬 1    📌 0

This conclusion can be made most powerfully in a brain organoid that does not have the intimate developmental interaction with other organ systems and thus excludes an internal setting due to cardiac signals, for example, of brain rhythms.

09.01.2025 19:26 — 👍 0    🔁 0    💬 1    📌 0

Employing human and murine brain organoids alongside ex vivo neonatal murine brain slices, we demonstrate that intrinsic neuronal sequences, which delineate low- and high-dimensional latent subspaces for information encoding, emerge independently of sensory experience.

09.01.2025 19:26 — 👍 0    🔁 0    💬 1    📌 0

In our updated manuscript we present strong evidence supporting the pre-configured brain hypothesis. Separating the effects of experience from intrinsic network dynamics has historically been challenging due to experimental limitations.

09.01.2025 19:26 — 👍 0    🔁 0    💬 1    📌 0

Protosequences in brain organoids model intrinsic brain states Neuronal firing sequences are thought to be the basic building blocks of neural coding and information broadcasting within the brain. However, when sequences emerge during neurodevelopment remains unk...

I’m thrilled to share our revised work on neuronal sequences in brain #organoids. It has been an absolute joy to collaborate with an incredible team of talented experimental and computational neuroscientists brought together by this project. www.biorxiv.org/content/10.1...

09.01.2025 19:26 — 👍 3    🔁 1    💬 1    📌 0