Biswajit Pradhan

The SMC Hinge is a Selective Gate for Obstacle Bypass - Nature Communications SMC complexes are ring-shaped motors that fold DNA by extruding loops, but how they navigate large DNA obstacles is unclear. Here, Liu et al., show that SMC complexes bypass obstacles by threading obs...

The hinge bypass gate paper is finally out! doi.org/10.1038/s414...

We show how loop-extruding SMC complexes can maintain DNA entrapment while bypassing obstacles on DNA — including transcription machinery & potentially other SMCs.

A lucky convergence of 3 projects lead to the initial discovery!

Herzlichen Glückwunsch!

Congratulations! That's a amazing team on DNA-SMC!

Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO

Delighted to announce our latest work on how Wadjet loads onto and establishes topological entrapment of plasmid DNA prior to initiating loop extrusion. At @gruberlab.bsky.social, Dubochet Center for Imaging and BSI @igbmc.bsky.social

www.cell.com/molecular-ce...

Amazing WadjetSMC-DNA gymnastics! fantastic data from @roisnehamelinf.bsky.social , @gruberlab.bsky.social and their team.

Our Wadjet-II paper by @roisnehamelinf.bsky.social is out in polished form: www.cell.com/structure/fu...

With a great preview by @kevincorbett.bsky.social & @amardeeep.bsky.social highlighting the potential of Wadjets:

Wadjet—Keeping a watchful eye on circular DNA.

www.cell.com/structure/fu...

beautiful structures everywhere in the paper. the artistic rendition looks so cool 💚

Congratulations Anuj!

Congrats, Max! And big thanks and congratulations to our coauthors at MPI for Marine Microbiology, Bremen, MPI-CBG in Dresden, and in-house at the MPI of Biophysics! It's been great working with you all! @mpimarinemicrobio.bsky.social, @mpicbg.bsky.social sky.social, @hummerlab.bsky.social

madness. That's some next-level Eule obsession

that's awesome. Congratulations!

Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy - Nature Cell Biology Licheva, Pflaum, Babic, Mancilla et al. show that low-affinity cargo–receptor interactions promote autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub ...

Check out our latest publication in @naturecellbiology.bsky.social on the role of phase separation in selective autophagy initiation! This was done in a fantastic collaboration with
‪@kraftlabfr.bsky.social‬

www.nature.com/articles/s41...

Short teaser below 👇👇👇

What a great way to end the year! ✨

Today in @cellpress.bsky.social we report the structure and function of the Shedu anti-phage defense system.

tinyurl.com/4crj6dnx

A long 🧵...

Hi all, I am very excited to share two positions (PhD and PostDoc) in my group on a EU-funded project ProAct.

More about the positions below.

Please share with your colleagues! This will be a great project to work on and also we offer a great environment at the BIOS group

Chromokinesin KIF4A activation of human condensin I involves a SLiM interfering with auto-inhibitory intramolecular interactions in the condensin complex, exemplifying a conserved mechanism for regulating diverse SMC complexes
@eecutts.bsky.social, Luis Aragon et al
www.embopress.org/doi/full/10....

Developing Imaging Solutions to Study the Dynamics of Human Condensin I at University of Sheffield on FindAPhD.com PhD Project - Developing Imaging Solutions to Study the Dynamics of Human Condensin I at University of Sheffield, listed on FindAPhD.com

Please share: Still plenty of time to apply for PhD projects in my lab using single-molecule methods to look at disordered regions and condensin complexes!
Contact me at e.cutts@sheffield.ac.uk
For details on how to apply: www.findaphd.com/phds/project...

Heartbeat of an early zebrafish embryo. Credit to Drs. Fengzhu Xiong & Sean Megason @harvardmed.bsky.social. #ZebrafishZunday 🧪

We have an opening for a 4 yr PhD interested in membrane remodelling and cryo-EM/ET of a minimal cell division machinery: edu.nl/bukan

You will be part of the EVOLF consortium in which 30 leading biochemists/biophysicists work together to explore if and how we can build autonomous synthetic cells.

Welcome! 🤞🏽 for more of those atomic-level awesome REELs! 😉🔬

topology sensing, very cool! another job for loop extrusion!

YouTube video by WEHImovies DNA Break Repair by Homologous Recombination (2024) Drew Berry wehi.tv

Delighted to publish my new molecular animation:

DNA Break Repair by Homologous Recombination

youtu.be/Xe-83tBcxhs

Excited to share this work, now out in Molecular Cell.
This was a fun collaboration between the Corbett lab and Kim lab.

Thanks, Olivia!

Thanks, Victor!

It's awesome that most of the coauthors are on Bluesky! 🤩

I had so much fun learning, collaborating with @amardeeep.bsky.social from @kevincorbett.bsky.social lab.

Thanks to @jessicakoenig.bsky.social and Martin Baaske from @eugenekimlab.bsky.social

Our work on SMC Wadjet is finally out! Congrats to all co-authors!

Thanks Luuk!

Thanks Tišma!🤩

Thanks so much!